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Research (RDMM)

Seed Fund Grant: April 2022

The Singhealth Duke-NUS Seed Fund aims to support investigators within the Singapore Rare Disease Models and Mechanisms (RDMM) Network in the fields of Cancer, Adult and Paediatric genetics. SingHealth Duke-NUS Genomic Medicine Centre (SDGMC) will fund three pilot projects on variant functionalization for one year with a $50K budget for each project.

The following were the application guidelines:

  1. A collaboration between a Clinician and a Basic Research Scientist is required. Both need to be members of RDMM network and with a current appointment >75% at a Singapore Institution.
  2. Types of research supported: Functionalization of genetic variants involved in Cancer, Adult and Paediatric Genetic Diseases.
  3. Potential from the data generated in the pilot to support a national grant proposal will be favourably considered.

The SD GMC is pleased to announce the three pilot projects that have been awarded the Seed Fund Grant.

Theme of ProposalTitle of ProjectPrinciple InvestigatorCo-Principal Investigator
PaediatricsInactivation of DRG1, encoding a translation factor GTPase, causes a Recessive Neurodevelopmental Disorder in humans and miceDr Bruno ReversadeDr Tan Ee Shien
AdultFunctional characterization in Asian CADASIL patients
Dr Zeng LiDr Adeline Ng
CancerUnderstanding mechanisms underlying pancreatic neuroendocrine tumour formationDr Adrian TeoDr Joanne Ngeow

The SDGMC would like to thank all applicants for their time and effort committed to submitting an application. For more information on future funding opportunities, kindly contact us at