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Drug Class: Commonly Known As: Category:
Anticoagulant Eliquis™ Adult

Apixaban - What is it for

What is Direct-acting Oral Anticoagulants (DOACs)?
Apixaban is a direct-acting oral anticoagulants (DOACs) which are medications used to prevent and treat blood clots.

This medication interferes with normal blood clotting (coagulation). It is commonly known as a “blood thinner” although it does not actually cause the blood to become less thick, only less likely to clot. It helps to reduce the risk of blood clot formation or to treat blood clots that have already formed. Apixaban does not dissolve clots that have already been formed but may prevent the clots from growing larger, while letting the body’s natural processes dissolve the clots.

People who are taking this medication do not require frequent blood tests to check the effectiveness of the medication. Your doctor may however order blood tests to check how well your kidneys and liver are working. If you have a severe kidney or liver problem, Apixaban may not be the right medication for you.

You are taking Apixaban for (please tick)

For stroke prevention in atrial fibrillation (Irregular heart rhythm)

For the prevention of blood clot formation following hip or knee replacement surgery

For the treatment or prevention of recurrence of deep vein thrombosis (blood clot in the leg)

For the treatment or prevention of recurrence of pulmonary embolism (blood clot which has travelled to the lung)

Other indication, please specify: _____________________________

Duration of treatment may vary from 3-6 months to long term depending on your condition.

Apixaban - Side Effects, Precautions, and Contraindications

What side effects can Apixaban cause?

The possible side effects of Apixaban include allergic reaction and nausea. The other side effect of apixaban is bleeding which is related mainly to Apixaban's effect of delaying blood clotting. Check with your doctor if you experience the following side effects:

  • Unexplained nose bleed
  • Bleeding from gums when brushing teeth
  • Prolonged bleeding from minor cuts (10-15 minutes) despite applying pressure on wound
  • Action: Check with your doctor as soon as possible if the bleeding does not stop within 15 min or if you feel unwell.

  • Excessive menstrual bleeding (women)
  • Action: For women, increased menstrual flow is common but check with your doctor if you feel unwell.

Serious effects of apixaban include:

  • Blood in urine or cloudy and dark urine
  • Black, sticky or tarry stools (not due to use of iron supplement)
  • Coughing up blood or coffee ground-like vomit
  • Unexplained large bruises or purplish area on skin
  • Sudden severe headache with nausea or loss of consciousness
  • Action: Check with your doctor immediately or admit yourself to the Accident and Emergency Department (A&E) if you experience any of the symptoms or feel unwell.

Before taking Apixaban, what precautions must I follow?

  • Inform your doctor if you are pregnant, planning to conceive or if you are breast-feeding.
  • You should consult your doctor or pharmacist before taking any other medication (either prescription or over-the-counter), nutritional supplements or herbal remedies. Some of these substances can interact with your medication.
  • You may bleed more easily. Avoid injury by using a soft toothbrush when brushing or an electric razor when shaving.
  • If you are going for any surgery or dental procedure, please inform your doctor or dentist that you take this medicine, as you may need to discontinue with the medicine prior to the procedure to prevent excessive bleeding.

What food or medicine must I avoid when I take Apixaban?

Apixaban - Dosage and How to Use

How should Apixaban be used?

Apixaban should be taken as prescribed by the doctor twice daily. It can be taken with or without food.

  • Do not skip or miss a dose. Do not take 2 doses at once, change the dose, or stop taking this drug without talking to your doctor.
  • You should also know the strength (mg) of your medicine, how it looks, and why your doctor prescribed it for you.
  • You should take your medication at the same time each day as told by your doctor or pharmacist.
  • Always refill your prescription before you run out of pills.

What should I do if I miss a dose?

You are taking this medicine two times daily. If there is any missed dose, take the dose as soon as you remember.

What should I do if I overdose?

Apixaban - Handling and Storage

How should I handle Apixaban safely?

How should I store Apixaban?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Apixaban safely?

Apixaban - Additional Information

Please call the Pharmacy at _________________ should you have any query.

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

​This leaflet answers some common questions about Rivaroxaban. It does not contain all the available information. It also does not take the place of talking to your doctor or pharmacist.

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