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Dabigatran

Drug Class: Commonly Known As: Category:
Pradaxa Adult

Dabigatran - What is it for

What are direct-acting oral anticoagulants (DOACs)?

  • Dabigatran is a direct-acting oral anticoagulants (DOACs) which are medicines used to prevent and treat blood clots.

  • This medicine interferes with normal blood clotting (coagulation). It is commonly known as a “blood thinner” although it does not actually cause the blood to become less thick, only less likely to clot. It helps to reduce the risk of blood clot formation or to treat blood clots that have already formed. Dabigatran does not dissolve clots that have already been formed but may prevent the clots from growing larger, while letting the body’s natural processes dissolve the clots.

  • People who are taking this medicine do not require frequent blood tests to check the effectiveness of the medicine. Your doctor may however order blood tests to check how well your kidneys and liver are working. If you have a severe kidney or liver problem, Dabigatran may not be the right medicine for you.

You are taking Dabigatran for (please tick when appropriate)

□ Stroke prevention in atrial fibrillation (Irregular heart rhythm)

□Prevention of blood clot formation following hip or knee replacement surgery

□ Treatment of deep vein thrombosis (blood clot in the leg) or prevention of recurrence

□ Treatment of pulmonary embolism (blood clot which has travelled to the lung) or prevention of recurrence

□ Other Indication: __________________________________

Duration of treatment may vary from 3 to 6 months to long term depending on your condition.

Dabigatran - Side Effects, Precautions, and Contraindications

What side effects can Dabigatran cause?

The possible side effects of Dabigatran include allergic reaction, headache/dizziness or gastrointestinal discomfort (stomach irritation, gastric like symptoms). The other common side effect of Dabigatran is bleeding which is related mainly to Dabigatran’s effect of delaying blood clotting.

Check with your doctor if you experience the following side effects:

  • Unexplained nose bleed
  • Bleeding from gums when brushing teeth
  • Prolonged bleeding from minor cuts (10-15 minutes) despite applying pressure on wound
    • Action: Check with your doctor as soon as possible if the bleeding does not stop within 15 min or if you feel unwell.
  • Excessive menstrual bleeding (women)
    • Action: For women, increased menstrual flow is common but check with your doctor if you feel unwell.

Serious effects of Dabigatran include:

  • Blood in urine or cloudy and dark urine
  • Black, sticky or tarry stools (not due to use of iron supplement)
  • Coughing up blood or coffee ground-like vomit
  • Unexplained large bruises or purplish area on skin
  • Sudden severe headache with nausea or loss of consciousness
    • Action: Check with your doctor immediately or admit yourself to the Accident and Emergency Department (A&E) if you experience any of the symptoms or feel unwell.

Before taking Dabigatran, what precautions must I follow?

  • Inform your doctor if you are pregnant, planning to conceive or if you are breast-feeding.
  • You should consult your doctor or pharmacist before taking any other medication (either prescription or over-the-counter), nutritional supplements or herbal remedies. Some of these substances can interact with your medication.
  • You may bleed more easily. Avoid injury by using a soft toothbrush when brushing or an electric razor when shaving.
  • If you are going for any surgery or dental procedure, please inform your doctor or dentist that you take this medication, as the medication may need to be discontinued prior to the procedure to prevent excessive bleeding.

What food or medicine must I avoid when I take Dabigatran?

Dabigatran - Dosage and How to Use

How should Dabigatran be used?

Dabigatran should be taken as prescribed by the doctor, administered once or twice daily. It can be taken with or without food.

When should I take Dabigatran?

  • Dabigatran should be swallowed whole with water, with or without food. Do not lie down for at least half an hour after taking it. This will lessen the chance of heartburn or an upset stomach.
  • Do not open the capsules and sprinkle the pellets over food or into beverages.
  • ​You should take your medication at the same time each day as told by your doctor or pharmacist. Do not skip or miss a dose. Do not take 2 doses at once, change the dose, or stop taking this drug without talking to your doctor.
  • You should also know the strength (mg) of your medication, how it looks, and why your doctor prescribed it for you.
  • Always refill your prescription before you run out of medicine.

What should I do if I miss a dose?

  • If you are taking the medication once daily and miss a dose, continue with your remaining daily dose at the same time the next day. Do not double the dose.
  • If you are taking this medication two times daily, take the missed dose as soon as you remember. However, if it is less than 6 hours before your next dose, skip the missed dose and take the next dose at your usual time. Do not double the dose.

What should I do if I overdose?

Dabigatran - Handling and Storage

How should I handle Dabigatran safely?

How should I store Dabigatran?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Dabigatran safely?

Dabigatran - Additional Information

Please call the Pharmacy at ________________________ should you have any query.

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

​​​​​​This leaflet answers some common questions about Dabigatran. It does not contain all the available information. It also does not take the place of talking to your doctor or pharmacist.

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