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Adj Asst Prof Leow Wei Qiang

Adj Asst Prof Leow Wei Qiang

MBBS, FRCPA, FAMS

Senior Consultant

Specialty: Anatomical Pathology

Sub-specialties: Gastrointestinal and Hepatopancreatobiliary Pathology

Clinical Appointments

  • Senior Consultant Anatomical Pathology Singapore General HospitalSingapore General Hospital

Academic Appointments

  • Programme Director, Pathology Residency Programme SingHealth Duke-NUS Pathology Academic Clinical Programme
  • Director, Medical Student Education SingHealth Duke-NUS Pathology Academic Clinical Programme

Profile

Dr Leow Wei Qiang is currently a senior consultant pathologist at the Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital. He graduated from the Faculty of Medicine, National University of Singapore in 2006 and did his postgraduate training in Histopathology with the then Histopathology and Cytology Sections, Department of Pathology, Singapore General Hospital. He was awarded the fellowships from the Royal College of Pathologists of Australasia and Academy of Medicine Singapore in 2015. His interests are in hepatopancreatobiliary and gastrointestinal pathology.

In 2016, he was awarded the Singhealth Health Manpower Development Plan to pursue advanced diagnostic training and research in hepatopancreatobiliary pathology and liver cancers at the Mount Sinai Liver Cancer Program at the Tisch Cancer Institute, under the tutelage of Professors Swan N. Thung and Josep M. Llovet respectively. The Tisch Cancer Institute at Mount Sinai Hospital, New York, is the only National Cancer Institute designated Cancer Center in the United States with a dedicated liver cancer program. He has strong research interests in non-alcoholic fatty liver disease, hepatocellular carcinoma, cholangiocarcinoma, and colorectal carcinoma. He has co-authored close to 40 peer reviewed articles, and has co-written the textbook titled “Atlas of Hepatocellular Carcinoma Pathology”. He is an ad-hoc reviewer for Histopathology, Clinical Cancer Research, Molecular Cancer Research and other medical journals. He is also enthusiastic about teaching at the undergraduate and postgraduate levels, holding the concurrent appointments of Programme Director, Singhealth Pathology Residency Program and Director of Medical Student Education, Singhealth Pathology Academic Clinical Programme. In addition, he holds clinical assistant professorships at Duke-NUS Medical School and School of Biological Sciences, Nanyang Technological University.

Education

  • ​Fellow of Royal College of Pathologists Australasia (FRCPA) 2015
  • Fellow of Academy of Medicine Singapore (FAMS) 2015
  • Bachelor of Medicine and Bachelor of Surgery (MBBS) 2006

Professional Appointments and Committee Memberships

  • Adjunct Assistant Professor, Duke-NUS Medical School
  • Adjunct Assistant Professor, School of Biological Sciences, Nanyang Technological University
  • Member, American Association for the Study of Liver Diseases (AASLD)
  • Member, United States and Canadian Academy of Pathology (USCAP)
  • International Corresponding Member, Hans Popper Hepatopathology Society (HPHS)
  • Member, Singapore Division of International Academy of Pathology (IAP)
  • Fellow, Academic Medicine Education Institute (AM.EI), Duke-NUS Medical School
  • Member, Singapore Society of Pathology (SSP)
  • Member, Singapore Medical Association (SMA)

Awards

  • Formation National Serviceman of the Year Award 2021
  • AMEI Outstanding Young Educator Golden Apple Award 2021
  • Khoo Pilot Award (Collaborative) 2018
  • Singhealth 10 Years Long Service Award 2017
  • Inspiring Mentor Award, Pathology Academic Clinical Program Research Day 2016, 2020, 2021
  • Health Manpower Development Plan (HMDP) Award 2016
  • Publication Prize, Pathology Academic Clinical Program Research Day 2015
  • Best Registrar Award 2013
  • Best Medical Officer Award 2012
  • RSAF Chief of Air Force Cardinal Award (Special) 2008
  • Best House Officer Award 2007

Research Interests

Publications

Selected Publications:

  1. Weiwei Zhai, Hannah Lai, Neslihan Arife Kaya, Chen Jianbin, Hechuan Yang, Bingxin Lu, Jia Qi Lim, Siming Ma, Sin Chi Chew, Khi Pin Chua, Jacob Josiah Santiago Alvarez, Pauline Jieqi Chen, Mei Mei Chang, Lingyan Wu, Brian K P Goh, Alexander Yaw-Fui Chung, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Juinn Huar Kam, Alfred Wei-Chieh Kow, Shridhar Ganpathi Iyer, Rawisak Chanwat, Jidapa Thammasiri, Boon Koon Yoong, Diana Bee-Lan Ong, Vanessa H de Villa, Rouchelle D Dela Cruz, Tracy Jiezhen Loh, Wei Keat Wan, Zeng Zeng, Anders Jacobsen Skanderup, Yin Huei Pang, Krishnakumar Madhavan, Tony Kiat-Hon Lim, Glenn Bonney, Wei Qiang Leow, Valerie Chew, Yock Young Dan, Wai Leong Tam, Han Chong Toh, Roger Sik-Yin Foo, Pierce Kah-Hoe Chow, Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in Hepatocellular Carcinoma: the PLANET study, National Science Review, 2021.
  2. Jerry C. Nagaputra, Tracy Jie Zhen Loh, Sangeeta Mantoo, Rafay Azhar, Vikneswaran Namasivayam, Wei Qiang Leow. A series of five patients with oxyntic gland adenoma: Deciphering the clinical and histological features of these rare gastric polyps. Human Pathology Reports, Volume 26, 2021.
  3. Yip Han Chin, Sneha Rajiv Jain, Ming Hui Lee, Cheng Han Ng, Snow Yunni Lin, Aaron Shengting Mai, Mark Dhinesh Muthiah, Fung Joon Foo, Raghav Sundar, David Eng Hui Ong, Wei Qiang Leow, Rupert Leong, Webber Pak Wo Chan. Small bowel adenocarcinoma in Crohn’s disease: a systematic review and meta-analysis of the prevalence, manifestation, histopathology, and outcomes. International journal of colorectal disease. 2021 Oct 26:1-2.
  4. Roser Pinyol, Sara Torrecilla, Huan Wang, Carla Montironi, Marta Piqué-Gili, Miguel Torres-Martin, Leow Wei-Qiang, Catherine E. Willoughby, Pierluigi Ramadori, Carmen Andreu-Oller, Patricia Taik, Youngmin A. Lee, Agrin Moeini, Judit Peix, Suzanne Faure-Dupuy, Tobias Riedl, Svenja Schuehle, Claudia P. Oliveira, Venancio A. Alves, Paolo Boffetta, Anja Lachenmayer, Stephanie Roessler, Beatriz Minguez, Peter Schirmacher, Jean-François Dufour, Swan N. Thung, Helen L. Reeves, Flair J. Carrilho, Charissa Chang, Andrew V. Uzilov, Mathias Heikenwalder, Arun Sanyal, Scott L. Friedman, Daniela Sia, Josep M. Llovet. Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis, Journal of Hepatology, 2021.
  5. Lam JH, Hong M, Koo SL, Chua CW, Lim KL, Wee F, Wan WK, Leow WQ, Yeo JG, Tan IB, Yeong J. CD30+ OX40+ Treg is associated with improved overall survival in colorectal cancer. Cancer Immunology, Immunotherapy. 2021 Feb 2:1-3.
  6. Saraf SA, Ying Tan LL, Leow WQ. A Diagnostic Approach to Combined Hepatocellular-Cholangocarcinomas (cHCC-CCA). Am J Clin Case Rep. 2021;2(1):1020.
  7. Nguyen, P. H., Ma, S., Phua, C. Z., Kaya, N. A., Lai, H. L., Lim, C. J., … Leow, W.Q.,... & Chew, V. (2021). Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma. Nature communications, 12(1), 1-13.
  8. Leow WQ, Bedossa P, Liu F, Wei L, Lim KH, Wan WK, Ren Y, Chang JP, Tan CK, Wee A, Goh GB. An Improved qFibrosis Algorithm for Precise Screening and Enrollment into Non-Alcoholic Steatohepatitis (NASH) Clinical Trials. Diagnostics. 2020 Sep;10(9):643.
  9. Tang, P. Y., New, L. M., & Leow, W. Q. (2020). Zooming for cells: Tele-education of histopathology residents during the COVID-19 pandemic. Proceedings of Singapore Healthcare.
  10. Ng HHM, Lee RY, Goh S, Tay ISY, Lim X, Lee B, Chew V, Li H, Tan B, Lim S, Lim JCT, Au B, Loh JJH, Saraf S, Connolly JE, Loh T, Leow WQ, Lee JJX, Toh HC, Malavasi F, Lee SY, Chow P, Newell EW, Choo SP, Tai D, Yeong J, Lim TKH. Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma. J Immunother Cancer. 2020 Aug;8(2):e000987.
  11. Lum JH, Cheah MC, Leow WQ, Wan WK, Lim TK, Chow WC, Chang JP, Goh GB. Clinical Profile of Non‐Alcoholic Fatty Liver Disease in Non‐Obese Patients. Journal of Gastroenterology and Hepatology. 2020 Jun 18.
  12. Lim Chong Teik, George Boon Bee Goh, Huihua Li, Tony Kiat-Hon Lim, Wei Qiang Leow, Wei Keat Wan, Rafay Azhar, Wan Cheng Chow and Rajneesh Kumar. Presence of Hepatic Steatosis Does Not Increase the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B Over Long Follow-Up. Microbiology Insights. 2020 Jan.
  13. Montal R, Sia D, Montironi C, Leow WQ, Esteban-Fabró R, Pinyol R, Torres-Martin M, Bassaganyas L, Moeini A, Peix J, Cabellos L. Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma. Journal of Hepatology. 2020 Mar 12.
  14. Liu F, Goh GB, Tiniakos D, Wee A, Leow WQ, Zhao JM, Rao HY, Wang XX, Wang Q, Wan WK, Lim KH, Romero-Gomez M, Petta S, Bugianesi E, Tan CK, Harrison SA, Anstee QM, Jason Chang PE and Wei L. qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis. Hepatology. 2019 Oct 10.
  15. Lam Jian Hang, Ng Harry Ho Man, Lim Chun Jye, Sim Xin Ni, Malavasi Fabio, Li Huihua, Loh Josh Jie Hua, Sabai Khin, Kim Joo-Kyung, Ong Clara Chong Hui, Loh Tracy, Leow Wei Qiang, Choo Su Pin, Toh Han Chong, Lee Ser Yee, Chan Chung Yip, Chew Valerie, Lim Tong Seng, Yeong Joe, Lim Tony Kiat Hon. Expression of CD38 on macrophages predicts improved prognosis in hepatocellular carcinoma. Frontiers in immunology. 2019 Sep 4;10:2093.
  16. Goh GB, Leow WQ, Liang S, Wan WK, Lim TK, Tan CK, Chang PE. Quantification of hepatic steatosis in chronic liver disease using novel automated method of second harmonic generation and two-photon excited fluorescence. Scientific reports. 2019 Feb 27;9(1):2975.
  17. Chang PE, Goh GB, Leow WQ, Shen L, Lim KH, Tan CK. Second harmonic generation microscopy provides accurate automated staging of liver fibrosis in patients with non-alcoholic fatty liver disease. PloS one. 2018 Jun 20;13(6):e0199166
  18. Phua LC, Goh S, Tai DW, Leow WQ, Alkaff SM, Chan CY, Kam JH, Lim TK, Chan EC. Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine. Cancer chemotherapy and pharmacology. 2018 Feb 1;81(2):277-89.
  19. Torrecilla S, Sia D, Harrington AN, Zhang Z, Cabellos L, Cornella H, Moeini A, Camprecios G, Leow WQ, Fiel MI, Hao K. Trunk mutational events present minimal intra-and inter-tumoral heterogeneity in hepatocellular carcinoma. Journal of hepatology. 2017 Dec 1;67(6):1222-31.
  20. Ng SB, Chua C, Ng M, Gan A, Poon PS, Teo M, Fu C, Leow WQ, Lim KH, Chung A, Koo SL. Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery. Scientific reports. 2017 Jan 19;7:40737.
  21. Suzuki Y, Ng SB, Chua C, Leow WQ, Chng J, Liu SY, Ramnarayanan K, Gan A, Ho DL, Ten R, Su Y. Multiregion ultra‐deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer. Molecular oncology. 2017 Feb;11(2):124-39.

Research Trials