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Asst Prof Wong Keng Lin, Francis

Asst Prof Wong Keng Lin, Francis

MBBS, MRCSEd, MMed (Orth), MCI (NUS), FRCSEd (Orth), FAMS (Orth)

Associate Consultant

Specialty: Orthopaedic Surgery

Conditions Treated by this Doctor:
Complex Wounds, General Orthopaedics, Knee - Cartilage Injuries, Sports Injuries.

Clinical Appointments

  • Associate Consultant Department of Orthopaedic Surgery Sengkang General HospitalSengkang General Hospital


Assistant Professor Francis Wong Keng Lin is an Associate Consultant in Department of Orthopaedic Surgery, Assistant Professor in Duke-NUS Graduate Medical School, Clinical Lecturer in NUS Yong Loo Lin School of Medicine, Clinical Teacher in NTU Lee Kong Chian School of Medicine, and Clinical Physician Faculty Member of the Singhealth Orthopaedic Surgery Residency Programme. He graduated as the pioneer resident in the Clinician Scientist Track from NUHS Orthopaedic Surgery Residency Programme, clinching the Best Senior Resident Award 3 consecutive years in a row. He was also the Chief Resident in his residency programme and was part of the nation-wide Singapore Chief Residency Programme (SCRP) in 2014-2015 (Cohort 2). He completed his Masters of Clinical Investigation (MCI), and is pursuing a part-time PhD in NUS, after receiving the National Medical Research Council (NMRC) Research Training Fellowship (RTF). He is currently investigating the use of Mesenchymal Stem Cells (MSC) exosomes as a cell-free injectable therapy for chondral defects of the knee and has published his translational research in a top-tiered Orthopaedic Surgery journal, Arthroscopy. Asst Prof Wong is active in both basic, translational, and clinical research, and has published more than 45 peer reviewed journal articles to date. He won the Singapore Orthopaedic Association Young Orthopaedic Investigator's Award in 2013 and currently holds several national level grants, including the NMRC New Investigator Grant (NIG).

His clinical interests are in sports medicine and sports surgery, in particular cartilage regeneration and restoration, where he became the very first Fellow of the International Cartilage Regeneration & Joint Preservation Society (ICRS) from South-East Asia. As a testimony of the quality of his clinical care, Asst Prof Wong is an award recipient of the Singapore Health Quality Service Awards (SHQSA) in 2020.

In terms of wound healing within the orthopaedic surgery realm, Asst Prof Wong has a special interest in healing complex wounds using innovative technologies, including limb salvage surgery for diabetic foot wounds. He has written more than 10 peer-reviewed articles and 2 book chapters related to the diabetic foot, including novel techniques for wound coverage and clinical cohort studies that look into different ways of wound healing with different negative pressure wound therapy products. He has received significant university funding to venture into various Clinical Trials that seeks to improve the healing rate of complex orthopaedic surgery wounds. He is currently the programme leader of the hospital's multi-disciplinary orthopaedic surgery wound and lower limb salvage service: Team Orthopaedic Podiatry (TOP), where nurses, doctors, and podiatrists come together to heal difficult wounds and give patients a new lease of life to walk again.



  • MBBS (Singapore)
  • MRCS (Edinburgh)
  • MMed (Ortho) (Singapore)
  • MCI (NUS) (Singapore)
  • FRCS (Ortho) (Edinburgh)
  • FAMS (Singapore)


Professional Appointments and Committee Memberships

  • Assistant Professor - Duke-NUS Graduate Medical School
  • Clinical Lecturer - NUS Yong Loo Lin School of Medicine
  • Clinical Teacher - NTU Lee Kong Chian School of Medicine
  • Clinical Physician Faculty Member, SingHealth Orthopaedic Surgery Residency Program
  • Fellow, Academy of Medicine, Singapore (Orthopaedic Surgery)
  • Executive Committee Member, Singapore Orthopaedic Association
  • Member, AO Trauma Foundation
  • Member, Asia-Pacific Knee, Arthroscopy and Sports Medicine Society (APKASS)
  • Fellow, International Cartilage Regeneration & Joint Preservation Society (ICRS)



  • National Medical Research Council Research Training Fellowship (NMRC-RTF) 2017
  • Recipient of Best Senior Resident Award, NUHS Orthopaedic Surgery Residency Programme for 3 consecutive years: 2014, 2015, 2016
  • Singapore Chief Residency Programme Graduate, 2014-2015 (Cohort 2)
  • International Cartilage Research Society (ICRS): 14th World Congress 9 – 12th April 2018: Certificate of Achievement: Merit Award "A Multi-faceted mechanism of Mesenchymal Stem Cell Exosome in Cartilage Repair
  • Singapore Orthopaedic Association: Young Orthopaedic Investigator's Award 2013. "Injectable Cultured Bone Marrow Derived Mesenchymal Stem Cells in Varus Knees with Cartilage Defects Undergoing High Tibial Osteotomy"
  • Fellowship Awardee, 2019 Vericel - International Cartilage Regeneration & Joint Preservation Society (ICRS) Travelling Fellowship 
  • Young Orthopaedic Surgeon Grant Recipient, Asia Pacific Orthopaedic Association (APOA) Sports Meeting incorporating Orthopaedic Research, Kuala Lumpur, Malaysia, April 2019
  • Travel Award Grant Recipient, 1st International Orthopaedic Postgraduate Basic Sciences Research Symposium, Kuala Lumpur, Malaysia, April 2019
  • Award Recipient, Singapore Health Quality Service Awards (SHQSA) 2020 – Silver

Research Interests

Publications and Research Trials


1.       Wong KL, Zhang S, Wang M, Ren X, Afizah H, Lai RC, Lim SK, Lee EH, Hoi PHJ, Toh WS.

Intra-Articular Injections of Mesenchymal Stem Cell Exosomes and Hyaluronic Acid Improve Structural and Mechanical Properties of Repaired Cartilage in a Rabbit Model.

Arthroscopy. 2020 Apr 14;S0749-8063(20)30276-0. doi: 10.1016/j.arthro.2020.03.031.

PMID: 32302651


2.       SHS Tan, SJ Hui, C Doshi, KL Wong, AKS Lim, JH Hui
The outcomes of distal femoral varus osteotomy in patellofemoral instability: A systematic review and meta-analysis
The Journal of Knee Surgery 33 (05), 504-512. doi: 10.1055/s-0039-1681043
PMID: 30822786
Times cited: 2

3.       SSH Tan, CKE Tjio, JRY Wong, KL Wong, JRJ Chew, JHP Hui, WS Toh
Mesenchymal Stem Cell Exosomes for Cartilage Regeneration: A Systematic Review of Preclinical In Vivo Studies
Tissue Engineering Part B: Reviews. 2020 Apr 15. doi:10.1089/ten.TEB.2019.0326
PMID 32159464 


4.       SHS Tan, CKE Tjio, JRY Wong, KL Wong, JRJ Chew, JHP Hui, WS Toh
A Systematic Review of Mesenchymal Stem Cell Exosomes for Cartilage Repair and Regeneration.
Tissue engineering. Part B, Reviews. 2020 Apr 15. Doi:10.1089/ten.TEB.2019.0326
PMID 32159464 


5.       SHS Tan, CH Wu, KL Wong, JH Hui
Correlations between ultrasonographic and subsequent radiographic findings of developmental dysplasia of the hips
Ultrasonography. 2020; 39 (1), 43
JIF: 0.847 


6.       T Panjwani, KL Wong, SHS Tan, G Liau, N Vaidya, L Krishna
Arthroscopic debridement has lower re-operation rates than arthrotomy in the treatment of acute septic arthritis of the knee: a meta-analysis
Journal of ISAKOS: Joint Disorders & Orthopaedic Sports Medicine. 2019 Sep 4 (6), 307-312 2019 


7.       Quok AT, Wong KL, Shen L, Lim JY, Toh WS, Lee EH, Hui HP
Equivalent 10-Year Outcomes After Implantation of Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation for Chondral Defects of the Knee. 2019 Aug 21. [Epub ahead of print] 
JIF: 6.093 


8.       Tan SHS, Wong KL, Lim AKS, Hui JH.
The earliest timing of ultrasound in screening for developmental dysplasia of the hips. Ultrasonography. 2019 Mar 3. doi: 10.14366/usg.18075. [Epub ahead of print]
PMID: 31117162 


9.       Loh JLM, Chan S, Wong KL, de Mel S, Yap ES.
Chemoprophylaxis in addition to mechanical prophylaxis after total knee arthroplasty surgery does not reduce the incidence of venous thromboembolism. Thromb J. 2019 Jun 20;17:9. doi: 10.1186/s12959-019-0200-1. eCollection 2019.
PMID: 31249474
JIF: 1.83, Times cited: 1 


10.   Tan SHS, Hui SJ, Doshi C, Wong KL, Lim AKS, Hui JH.
The Outcomes of Distal Femoral Varus Osteotomy in Patellofemoral Instability: A Systematic Review and Meta-Analysis. J Knee Surg. 2019 Mar 1. doi: 10.1055/s-0039-1681043. [Epub ahead of print]
PMID: 30822786
JIF: 2.079 


11.   Tan SHS, Lim SY, Wong KL, Doshi C, Lim AKS, Hui JH.
The Outcomes of Isolated Distal Realignment Procedures in Patellofemoral Instability: A Systematic Review and Meta-analysis. J Knee Surg. 2019 Mar 1. doi: 10.1055/s-0039-1681052. [Epub ahead of print]
PMID: 30822787 


12.   Panjwani T, Mok YR, Wong KL, Chan CX, Toh SJ, Krishna L.
The presence of concomitant intra-articular injuries and bone bruise does not affect pre-operative knee pain and symptoms in patients undergoing anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2018 Sep 29. doi: 10.1007/s00167-018-5168-z
JIF: 3.21 


13.   Tan SHS, Wong KL, Hui JH.
Incorporating risk factors in the development of the screening programme for developmental dysplasia of the hips.J Pediatr Orthop B. 2019 Mar;28(2):111-114. doi: 10.1097/BPB.0000000000000567.
PMID: 30461505
JIF: 0.610 


14.   Tan SHS, Chng KSJ, Lim BY, Wong KL, Doshi C, Lim AKS, Hui JH. The Difference Between Cartilaginous and Bony Sulcus Angles for Patients with or without Patellofemoral Instability: A Systematic Review and Meta-Analysis  J Knee Surg. 2019 Jan 24. doi: 10.1055/s-0038-1677541. [Epub ahead of print]
PMID: 30677785
JIF: 2.079 


15.   Mok YR, Wong KL, Panjwani T, Chan CX, Toh SJ, Krishna L.
Anterior Cruciate Ligament Reconstruction Performed Within 12 Months Of The Index Injury Is Associated With A Lower Rate Of Medial Meniscus Tears. Knee Surg Sports Traumatol Arthrosc. 2018 Jul 5. doi: 10.1007/s00167-018-5027-y. [Epub ahead of print] PubMed PMID: 29978305.
JIF: 3.22, Times Cited: 2 


16.   Krishna L, Panjwani T, YR Mok, KL Wong, A Singh, SJ Toh
The Use Of The Five-Strand Hamstring Autograft Technique In Increasing Graft Size In Anterior Cruciate Ligament Reconstruction. Arthroscopy: The Journal of Arthroscopic and RelatedSurgery. 2018 Sep;34(9):2633-2640
JIF: 4.292 , Times Cited: 1


17.   Chan XY, Wong KL, Toh SJ, Lingaraj K.
Epidemiology Of Patients With Anterior Cruciate Ligament Injuries Undergoing Reconstruction Surgery In A Multi-Ethnic Asian Population. Res Sports Med. 2018 Jul 9:1-13. doi: 10.1080/15438627.2018.1492391. [Epub ahead of print] PubMed PMID: 29985059.
JIF: 2.040 


18.   Aravindh P, Wu T, Chan CX, Wong KL, Krishna L.
Association Of Compartmental Bone Bruise Distribution With Concomitant Intra-Articular And Extra-Articular Injuries In Acute Anterior Cruciate Ligament Tears After Noncontact Sports Trauma. Orthop J Sports Med. 2018 Apr 24;6(4):2325967118767625. doi: 10.1177/2325967118767625. eCollection 2018 Apr. PubMed PMID: 29780838; PubMed Central PMCID: PMC5954320.
JIF: 0.26 


19.   Krishna L, Tan XY, Thangaraja A, Wong KL.
Five-Strand Hamstring Autograft In Primary Anterior Cruciate Ligament Reconstruction.
J Knee Surg. 2018 Apr 4. doi: 10.1055/s-0038-1641175. [Epub ahead of print] PubMed PMID: 29618144.
JIF: 2.08, Times Cited: 1 


20.   Krishna L, Tan XY, Wong KL, Toh SJ.
A 5-Strand Hamstring Autograft Achieves Outcomes Comparable To Those Of A 4-Strand Hamstring Autograft With A Graft Diameter Of 8 Mm Or More In Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med. 2018 Mar 19;6(3):2325967118760815. doi:10.1177/2325967118760815. eCollection 2018 Mar.
JIF: 0.26, Times Cited: 2


21.   Chan CX, Wong KL, Toh SJ, Krishna L.
Chinese Ethnicity Is Associated With Concomitant Cartilage Injuries In Anterior Cruciate Ligament Tears. Orthop J Sports Med. 2018 Jan 18;6(1):2325967117750083. doi:10.1177/2325967117750083. eCollection 2018 Jan.
JIF: 0.26


22.   Hey HW, Wong KL, Gatam AR, Lim JL, Wong HK.
Delayed Lymphocele Formation Following Lateral Lumbar Interbody Fusion Of The Spine. Eur Spine J. 2016 Jun 27. [Epub ahead of print] PubMed PMID: 27349755.
JIF: 2.132, Times Cited: 4


23.   Daruwalla ZJ, Huq SS, Wong KL, Nee PY, Leong KM, Pillay KR, Murphy DP.
Hip Fractures, Preceding Distal Radius Fractures And Screening For Osteoporosis: Should We Be Screening Earlier? A Minimum 10-Year Retrospective Cohort Study At A Single Centre. Osteoporos Int. 2015 Oct 28. [Epub ahead of print]
JIF: 4.17, Times Cited: 8


24.   H Daruwalla ZJ, Wong KL, Malhotra R, Leong KM, Nee PY, Murphy DP.
Hip Fracture Surgery In Nonagenarians – The Devil's Advocate? J Am Geriatr Soc. 2016 Jan;64(1):210-1. doi: 10.1111/jgs.13914. PubMed PMID: 26782879.
JIF: 3.82


25.   Loh JL, Wong KL, Hwang S, Shen L, Murphy DP, Daruwalla ZJ
Orthopedic Asymmetry And Clavicle Length. Clin Anat. 2015 May 14. doi: 10.1002/ca.22540.[Epub ahead of print]


26.   Wong KL, Peter L, Liang S, Shah S, Johandi F, Wang W.
Changes In Dimensions Of Total Knee Arthroplasty Anterior Knee Dressings During Flexion: Preliminary Findings. Int J Orthop Trauma Nurs. 2015 Nov;19(4):179-83. doi: 10.1016/j.ijotn.2015.06.002.
JIF: 0.32, Times Cited: 1 


27.   Wu KY, Daruwalla ZJ, Wong KL, Murphy D, Ren HL.
Development And Selection Of Asian-Specific Humeral Implants Based On Statistical Atlas:Toward Planning Minimally Invasive Surgery. Int J Comput Assist Radiol Surg. 2015 Jan 9.
JIF: 1.659, Times Cited: 4 


28.   Pearce CJ, Wong KL, Chong KW
Calcaneal Fractures: Selection Bias Is KeyBone Joint J. 2015 Jul;97-B(7):880-2. doi: 10.1302/0301-620X.97B7.35305.
JIF: 2.801, Times Cited: 10 


29.   Daruwalla ZJ, Huq SS, Wong KL, Nee PY, Murphy DP
Publish Or Perish -Presentations At Annual National Orthopaedic Meetings And Their Correlation With Subsequent Publication. J Orthop Surg Res. 2015 May 7;10:58. doi: 10.1186/s13018-015-0203y.
JIF: 1.39, Times Cited: 16


30.   Hey HW, Wong KL, Long AS, Hee HT.
Single-Level Anterior Corpectomy With Fusion Versus 2-Level Anterior Cervical Decompression With Fusion: A Prospective Controlled Study With 2-Year Follow-Up Using Cages For Fusion. Ann Acad Med Singapore 2015 May; 45(5): 188-190
JIF: 1.362, Times Cited: 1


31.   Wu K, Wong KL, Ng SJ, Quek ST, Li BP, Murphy DP, Daruwalla ZJ, H Ren
Statistical Atlas-Based Morphological Variation Analysis Of The Asian Humerus: Towards Consistent Allometric Implant Positioning Statistical Atlas Based Analysis. Int J Comput Assist Radiol Surg. 2014 Jun 13. [Epub ahead of print]
JIF: 1.659, Times Cited: 9


32.   Chung SR, Wong KL, Cheah EJ.
The Lateral Lesser Toe Fillet Flap For Diabetic Foot Soft Tissue Closure: Surgical Technique And Case Report. Diabet Foot Ankle. 2014 Dec 18;5:25732. doi: 10.3402/dfa.v5.25732. eCollection 2014.
JIF: 1.213, Times Cited: 5


33.   Wong KL, Daruwalla ZJ, Lan JH, Tan SH, Shen L, Chua WL, Manohara R, Lingaraj K
Postoperative Venous Thrombotic Events For Surgically Treated Hip Fractures In Asian Elderly Patients With And Without Chemoprophylaxis . Hip International DOI:10.5301/hipint.5000153
JIF: 0.763, Times Cited: 6


34.   Chua WL, Soumen DD, Wong KL, Kagda F, Murphy D
Early Versus Late Flap Coverage For Open Tibial Fractures. J Orthop Surg (Hong Kong). 2014 Dec; 22(3):294-8.
JIF: 0.7, Times Cited: 6


35.   Chan SY,  Wong KL, Lim JX, Tay YL, Nather A
The Role Of Renasys-GOTM In The Treatment Of Diabetic Lower Limb Ulcers: A Case Series. Diabet Foot Ankle. 2014 Nov 17;5:24718. doi: 10.3402/dfa.v5.24718. eCollection 2014.
JIF: 1.213, Times Cited: 10


36.   Wong KL, Nather A, Chanyarungrojn PA, Liang S, Ong EL, Elangovan RD, Lim CT
Clinical Outcomes Of Ray Amputation In Diabetic Foot Patients. Ann Acad Med Singapore. 2014 Aug; 43(8):428-32.
JIF: 1.362, Times Cited: 4 


37.   Daruwalla ZJ, Wong KL, Thambiah J.
The Application of Telemedicine in Orthopaedic Surgery in Singapore: A pilot study on a secure, Mobile Telehealth Application and Messaging Platform. Journal of Medical Internet Research. 2014 Jun ;2(2):e28
JIF: 4.7, Times Cited: 12


38.   Daruwalla ZJ, Wong KL, Pillay KR, Leong KM, Murphy DP
Does Ageing Singapore Need An Electronic Database Of Hip Fracture Patients? The Value And Role Of A National Joint Registry And Electronic Intertrochanteric And Neck Of Femur Fracture Database.
Singapore Med J 2014;55(5):287-288.
JIF: 0.73, Times Cited: 10 


39.   Nather A, Wong KL, Lim SA, Ng ZW, Hey HW.
The Modified Pirogoff's Amputation In Treating Diabetic Foot Infections: Surgical Technique And Case Series. Diabet Foot Ankle. 2014 Apr 3;5. doi: 10.3402/dfa.v5.23354. eCollection 2014.
JIF: 1.213, Times Cited: 7


40.   Wong KL, Lee BL, Tai BC, Law P, Lee EH, Hui HP
Injectable Cultured Bone Marrow Derived Mesenchymal Stem Cells In Varus Knees With Cartilage Defects Undergoing High Tibial Osteotomy: A Prospective, Randomized Controlled Clinical Trial With 2 Years Follow Up. Arthroscopy. 2013 Dec;29(12):2020-8. doi: 10.1016/j.arthro.2013.09.074.
JIF: 3.191, Times Cited: 210 


41.   Wong KL, Nather A, Shen L, Chang ZY, Wong TC, Chin TL
Clinical Outcomes Of Below Knee Amputations In Diabetic Foot Patients Ann Acad Med Singapore 2013;42:388-94
JIF: 1.362, Times Cited: 23 


42.   Nather A, Wong KL
Distal Amputations For The Diabetic Foot. Diabet Foot Ankle. 2013 Jul 16;4. doi:10.3402/dfa.v4i0.21288.  Print 2013.
JIF: 1.213, Times Cited: 23


43.   Nather A, Wong KL, David V, Pereira BP
Allografts with autogenous platelet-rich plasma for tibial defect reconstruction: a rabbit study. Journal of Orthopaedic Surgery 2012 Dec, 20(3) 375-380.
JIF: 1.215Times Cited: 14


44.   Aziz Z, Wong KL, Nather A, Chan YH
Predictive Factors For Lower Extremity Amputations In Diabetic Foot Infections.Diabetic Foot & Ankle 2011, 2: 7463 - DOI: 10.3402/dfa.v2i0.7463
JIF: 1.213, Times Cited: 52


45.   Nather A, Wong KL, Ong HJ, Aziz Z, Feng MC, Lin CB
Assessment Of Sensory Neuropathy In Patients With Diabetic Foot Problems. Diabetic Foot & Ankle 2011: 2: 6367 - DOI: 10.3402/dfa.v2i0.6367
JIF: 1.213, Times Cited: 26


46.   Wong KL, Daguman R, Lim KH, Shen L, Lingaraj K
Incidence Of Deep Vein Thrombosis Following Total Hip Arthroplasty: A Doppler Ultrasonographic Study. J Orthop Surg (Hong Kong). 2011 Apr;19(1):50-3.
JIF: 0.7, Times Cited: 21


47.   Nather A, Ng YH, Wong KL, Sakharam JA
Effectiveness Of Bridge V.A.C Dressings In The Treatment Of Diabetic Foot Ulcers. Diabetic Foot & Ankle 2011: 2: 5893 - DOI: 10.3402/dfa.v2i0.5893
JIF: 1.213, Times Cited: 20


48.   Nather A, Chionh SB, Wong KL, Chan XB, Shen L, Tambyah P, Jorgensen A, Nambiar A
Value Of Team Approach Combined With Clinical Pathway For Diabetic Foot Problems: A Clinical Evaluation. Diabetic Foot & Ankle 2010, 1: 5731 - DOI: 10.3402/dfa.v1i0.5731
JIF: 1.213, Times Cited: 27


49.   Nather A, Chionh SB, Wong KL, Koh SQ, Chan YH, , Li XY,  Nambiar A.
Socio-Economic Profile Of Diabetic Patients With And Without Foot Problems.Diabetic Foot & Ankle 2010, 1: 5523 - DOI: 10.3402/dfa.v1i0.5523
JIF: 1.213, Times Cited: 19


Books & Chapters

1.       Choi CE, Wong KL, HP Hui - 2015
Pediatric and Adolescent Knee Surgery.
Chapter 27: Technique: Frontiers of Cartilage Restoration 


2.       Lam D, Wong KL, Law P, H.P. Hui - 2014
Techniques in Cartilage Repair Surgery, Chapter 17: Injectable Autologous Bone- Marrow-Derived Mesenchymal Stem Cells for Cartilage Repair: The Singapore Technique


3.       Nather A, l Singh G, Teo ZL, Wong KL - 2012

The Diabetic foot. Edited by Aziz Nather (National University of Singapore, Singapore) Section 6. Guide to operative surgery. Minor Amputations. Pg 309. DOI. 10.1142/9789814417013_0023. Times Cited: 6

Research Trials