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Assoc Prof Chan Ling Ling

Assoc Prof Chan Ling Ling

MBBS (S’pore), FRCR, FAMS

Senior Consultant

Specialty: Diagnostic Radiology

Sub-specialties: Neuroradiology

Clinical Appointments

  • Senior Consultant Diagnostic Radiology Singapore General HospitalSingapore General Hospital

Academic Appointments

  • Associate Professor SingHealth Duke-NUS Radiological Sciences Academic Clinical Programme
  • Neuroscience & Behavioral Disorders, Signature Research Programme

Profile

Dr Chan Ling Ling is a Senior Consultant in DDR, SGH and an Associate Professor at Duke-NUS. After specialist accreditation in Diagnostic Radiology, she completed her Neuroradiology fellowship at The Baylor College of Medicine and University of Texas MD Anderson Cancer Center, Houston, Texas.

As senior faculty of the DDR Neuroradiology service, she works closely with the RADSC team to support clinical service and teaching of residents and fellows. She is involved in the Residency programme and MMed-FRCR 2B Exams.

She is a PI and collaborator of multiple national grants, and a two-time awardee of the NMRC Clinician Scientist Award. She has 2589 citations, an i10-index of 78 and h-index of 29, multiple scientific awards and led >10 award-winning presentations by both under- and post-graduate students at radiological conferences including RSNA, SMRT and ISMRM. She leads a neuroimaging research lab focusing on chronic neurological diseases.

She has held numerous DDR administrative portfolios including directorships of Neuroradiology Subsection, Advance Imaging Centre, Clinical Services, and is now Director of Research. She serves on the MOH research accreditation panel and editorial board of Annals, Academy of Medicine, Singapore, was the Honorary Secretary, Singapore Radiological Society and currently Treasurer of its Neuroradiology Subsection.

Education

  • National University of Singapore, Medical Faculty, Singapore, SG

Professional Appointments and Committee Memberships

  • Director, Research Committee, DDR, SGH, 2020
  • Member, Intel-COVID Taskforce, DDR, SGH, 2020
  • Treasurer, Neuroradiology Subsection, Singapore Radiological Society, 2019

Awards

  • The Long Service Medal, Prime Minister's Office, Singapore 2019 
  • SingHealth GCEO Excellence Award for Outstanding Clinician Researcher, 2019
  • NMRC Clinician Scientist Investigator Award 2018

Research Interests

Neurodegeneration, dementia, Parkinsonism and gait disorders, traumatic brain injury, thyroid eye disease, Meniere’s imaging, neurovascular conflicts, scoliosis, advanced MR techniques (dMRI, fMRI, VWI, SWI, NMS, MWI, Morphometry) and big data AI 

Publications

Selected publications (of >150):

  1. *Koh YH, *Shih YC, Lim SL, Kiew YS, Lim EW, Ng SM, Ooi LQR, Tan WQ, Chung YC, Rumpel H, Tan EK, Chan LL. Evaluation of trigeminal nerve tractography using two-fold-accelerated simultaneous multi-slice readout-segmented echo planar diffusion tensor imaging. Eur Radiol. 2020 Sep 1. doi: 10.1007/s00330-020-07193-x. Online ahead of print.   
  2. *Lim KC, *Santhosh RS, Kee TP, Sim S, Ho MI, Ho JXM, Mcadory LE, Lim WEH, Chan LL. Cryptic Asymptomatic Parasellar High Signal on Time-of-Flight MR Angiography: How to Resolve the Clinical Conundrum. Neuroradiology 2020 Jul 26. doi: 10.1007/s00234-020-02482-0. 
  3. Chan LL, Tan EK. Evidence of Added Value of Chest CT in Coronavirus Disease (COVID-19) Pneumonia With Initial Negative RT-PCR Results. AJR Am J Roentgenol. 2020 Sep;215(3):W41. doi: 10.2214/AJR.20.23815.
  4. Lim JLL, McAdory LE, Tang PH, Conceicao EP, Lim WEH, De Silva DA, Tan EK, Chan LL. Appropriateness of MRI brain orders: Application of American and British guidelines. J Neurol Sci. 2020 Jul 15;414:116874. doi: 10.1016/j.jns.2020.116874.
  5. Chan LL, Tan EK.  Radiological Response to the Call of the Pandemic: Clinico-Neuroradiological Correlates of Acute Necrotizing Encephalopathy in COVID-19 Infection. Radiology Apr 9, 2020 https://pubs.rsna.org/page/radiology/blog/2020/4/radiological_response_to_the_pandemic?fbclid=IwAR0tE9Kzdwk3ofACNzxpg6_FvqsCRl0xMPaJq--Rnu-xamZTcHAbazy9wso  
  6. Zhang AY, Lam SSW, Ong MEH, Tang PH, Chan LL. Explainable AI: Classification of MRI Brain Scans for Quality Improvement. BDCAT Dec 2019;95-102. https://doi.org/10.1145/3365109.3368791  
  7. Chan LL. Intracranial and Extracranial Atherosclerosis: More Similar Than Different? AJNR Am J Neuroradiol. 2019 Dec;40(12):2023-2024. doi: 10.3174/ajnr.A6349
  8. *Fang E, *Ann CN, Maréchal B, Lim JX, Tan SYZ, Li H, Gan J, Tan EK, Chan LL. Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load. J Magn Reson Imaging. 2020 Mar;51(3):748-756. 
  9. Tan SYZ, Keong NCH, Malathi R, Li HH, Ooi LQR, Tan EK, Chan LL. Periventricular White Matter Abnormalities on Diffusion Tensor Imaging of Postural Instability Gait Disorder Parkinsonism. AJNR Am J Neuroradiol. 2019 Apr;40(4):609-613. doi: 10.3174/ajnr.A5993. Epub 2019 Mar 14. 
  10. Wen MC, Chan LL, Tan LC, Tan EK. Depression, anxiety, and apathy in Parkinson's disease: insights from neuroimaging studies. Eur J Neurol. 2016 Jun;23(6):1001-19. doi: 10.1111/ene.13002
  11. Chan LL, Ng KM, Yeoh CS, Rumpel H, Li HH, Tan EK. Putaminal Diffusivity Correlates With Disease Progression in Parkinson's Disease: Prospective 6-Year Study. Medicine (Baltimore). 2016 Feb;95(6):e2594. doi: 10.1097/ MD.0000000000002594.
  12. Tan WQ, Yeoh CS, Rumpel H, Nadkarni N, Lye WK, Tan EK, Chan LL. Deterministic Tractography of the Nigrostriatal-Nigropallidal Pathway in Parkinson's Disease. Sci Rep. 2015 Dec 1;5:17283.
  13. Chan LL, Ng KM, Rumpel H, Fook-Chong S, Li HH, Tan EK.  Transcallosal Diffusion Tensor Abnormalities In Predominant Gait Disorder Parkinsonism. Parkinsonism Relat Disord 2014 Jan;20(1):53-9.
  14. Rumpel H, Chong Y, Porter DA, Chan LL. Benign versus metastatic vertebral compression fractures: combined diffusion-weighted MRI and MR spectroscopy aids differentiation. Eur Radiol. 2013 Feb;23(2):541-50. doi: 10.1007/s00330-012-2620-1.
  15. Ng AC, Wai DC, Tai ES, Ng KM, Chan LL. Visceral adipose tissue, but not waist circumference is a better measure of metabolic risk in Singaporean Chinese and Indian men. Nutrition and Diabetes 2012 Aug 6;2:e38. doi: 10.1038/nutd.2012.12. 
  16. Chan LL, Ng KM, Fook-Chong S, Lo YL, Tan EK. Three-dimensional MR volumetric analysis of the posterior fossa CSF space in hemifacial spasm.  Neurology. 2009 Sep 29;73(13):1054-7.
  17. Chan LL, Tan HE, Fook-Chong S, Teo TH, Lim LH, Seah LL. Graves’ Ophthalmopathy: The Bony Orbit in Optic Neuropathy, Its Apical Angular Capacity and Impact on Prediction of Risk.  AJNR Am J Neuroradiol 2009 Mar;30(3):597-602. Epub 2009 Jan 15.
  18. Tan JSP, Tan KL, Lee JC, Wan CM, Leong JL, Chan LL.  Comparison of Eye Lens Dose on Neuroimaging Protocols between 16- and 64-Section Multidetector CT: Achieving the Lowest Possible Dose.  AJNR Am J Neuroradiol 2009 Feb;30(2):373-7. Epub 2008 Oct 14.
  19. Chan LL, Lee E, Fook-Chong S, Tan EK.  Case control MR-CISS and 3D TOF MRA imaging study of medullary compression and hypertension in hemifacial spasm.  Mov Disord 2008 Oct 15;23(13):1820-4.
  20. Chan LL, Sitoh YY, Chong J, See SJ, Umapathi TN, Lim SH, Ong B. Application of the McDonald MRI criteria in multiple sclerosis. Ann Acad Med Singapore 2007 Aug;36(8):647-54.
  21. Chan LL, Rumpel H, Yap K, Lee E, Loo HV, Ho GL, Fook-Chong S, Yuen Y, Tan EK. Case control study of diffusion tensor imaging in Parkinson's disease. J Neurol Neurosurg Psychiatry 2007 Dec;78(12):1383-6. Epub 2007 Jul 5.
  22. Chan LL, Lo YL, Lee E, Fook-Chong S, Tan EK. Ventrolateral medullary compression in hypertensive patients with hemifacial spasm. Neurology 2005;65(9):1467-70.
  23. Lo YL, Chan LL, Lim W, Tan SB, Tan CT, Chen JL, Fook-Chong S, Ratnagopal P. Systematic correlation of transcranial magnetic stimulation and magnetic resonance imaging in cervical spondylotic myelopathy. Spine 2004 May 15;29(10):1137-45.
  24. Tan EK, Chan LL, Yu GX, Rumpel H, Wilder-Smith E, Wong MC. Vascular Parkinsonism in moyamoya: microvascular biopsy and imaging correlates.  Ann Neurol 2003 Dec;54(6):836-40.
  25. Ondo W, Chan LL, Levy JK.  Vascular Parkinsonism: Clinical correlates predicting motor improvement after lumbar puncture.  Movement Disorders 2002;17:91-97
  26. Tan NC, Chan LL, Tan EK.  Hemifacial spasm and involuntary facial movements.  QJM 2002;95:493-500
  27. Chan LL, Chong J, Gillenwater AM, Ginsberg LE. The pterygopalatine fossa: postoperative MR imaging appearance. AJNR Am J Neuroradiol 2000;21:1315-1319. 
  28. Chan LL, Singh S, Jones D, Diaz EM, Ginsberg LE. Imaging of mucormycosis skull base osteomyelitis. AJNR Am J Neuroradiol 2000;21:828-831.
  29. Chan LL, Tan BS, Kaw GJL, Lo RHG, Yeong KY, Htoo MM, Tan EK.  Radiological placement of 211 central venous catheters: outcome and complications. Annals, Academy of Medicine 1999:28:481-487
  30. Chan LL, Chee TSG, Thoo FL. MR features of granulomatous myositis. Clin Radiol 1997;52(10):794-6.

Research Trials