Tegafur/Gimeracil/Oteracil (TS-1®)

What is TS-1 for?

TS-1® is a combination oral chemotherapy used to treat certain types of advanced cancer e.g. gastric, pancreatic, head and neck.   

How should I take or use TS-1?

What should I do if I forget to take or use TS-1?

If you miss a dose of TS-1®, take it as soon as you remember. However if it is too near to your next dose, skip the missed dose and go back to your usual dosing time. Do not double the dose.

What precautions should I take when taking or using TS-1?

• Use effective birth control during treatment and for 6 months after stopping TS-1®. Inform your doctor if you or your partner suspect or plan for pregnancy.
• Inform your doctor or pharmacist if you:
• Are taking other medication or supplements e.g. warfarin, phenytoin.
• Have any other medical conditions e.g. heart problems.

What are some common side effects of TS-1?

• Nausea and vomiting
• Diarrhea
• Tiredness and lack of energy
• Decrease white and red blood cells, platelets
  To minimize infection risk, ensure personal hygiene and take adequate precautions e.g. avoiding crowded areas. 

Inform your doctor if any of the following occurs:

• Fever of 38°C or higher, sores in the mouth and throat 
• Sudden onset of cough or shortness of breath
• Chest pain or irregular heartbeat
• Unusual bleeding, bruising or black stools
• Severe diarrhea uncontrolled by anti-diarrheal medication e.g. more than 4 times/day
• Yellowing of the eyes or skin, dark tea-coloured urine and severe abdominal pain
• Skin rash or itch

How should I store TS-1?

• Keep away from children
• Keep in a cool, dry place, away from direct sunlight
• Store at room temperature

How should I handle TS-1 safely?

Do not crush, chew or open the capsules.

What should I do if I overdose?

If you overdose on this medication, inform your doctor immediately.