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Sirolimus

Drug Class: Commonly Known As: Category:
mTOR Kinase Inhibitor Rapamune® Cancer-related, Children, Adult

Sirolimus - Side Effects, Precautions, and Contraindications

What side effects can Sirolimus cause?

  • Nausea and/or vomiting may sometimes occur when you first start taking Sirolimus
  • Acne
  • Mild to moderate headache
  • Slight indigestion or diarrhea may sometimes occur
  • Increased cholesterol or lipid levels
    Your blood cholesterol should be monitored regularly. Discuss a proper follow-up plan with your doctor.
  • Body aches and tiredness on some days.
    Try to avoid heavy-duty work or long outings on such days.

Inform your doctor if you experience any of the following:

  • Allergic reactions – rashes, swelling, breathing difficulty
  • Rapid heartbeat or chest pain
  • Signs of infection – fever or chills, cough, sore throat, pain or difficulty in urinating
  • Signs of bleeding – bruising, black tarry stools, blood in the urine
  • Unusual weakness, tiredness or light-headedness

Before taking Sirolimus, what precautions must I follow?

  • ​Use effective birth control before treatment, during treatment and for at least 12 weeks after stopping treatment.
  • Do not take medicines and supplements without first informing your doctor and pharmacist.
  • Avoid going to crowded places or being near sick people to minimize your risk of getting an infection.

What food or medicine must I avoid when I take Sirolimus?

​Avoid grapefruit and its juice while you are on Sirolimus.

Sirolimus - Additional Information

  • Updated on Wednesday, June 6, 2018
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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