Sirolimus

• Nausea and/or vomiting may sometimes occur when you first start taking Sirolimus
• Acne
• Mild to moderate headache
• Slight indigestion or diarrhea may sometimes occur
• Increased cholesterol or lipid levels
  Your blood cholesterol should be monitored regularly. Discuss a proper follow-up plan with your doctor.
• Body aches and tiredness on some days.
  Try to avoid heavy-duty work or long outings on such days.

Inform your doctor if you experience any of the following:

• Allergic reactions – rashes, swelling, breathing difficulty
• Rapid heartbeat or chest pain
• Signs of infection – fever or chills, cough, sore throat, pain or difficulty in urinating
• Signs of bleeding – bruising, black tarry stools, blood in the urine
• Unusual weakness, tiredness or light-headedness

• ​Use effective birth control before treatment, during treatment and for at least 12 weeks after stopping treatment.
• Do not take medicines and supplements without first informing your doctor and pharmacist.
• Avoid going to crowded places or being near sick people to minimize your risk of getting an infection.

​Avoid grapefruit and its juice while you are on Sirolimus.