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Pazopanib

Drug Class: Commonly Known As: Category:
Multi-Kinase Inhibitor Votrient® Cancer-related

Pazopanib - What is it for

​Pazopanib is a targeted medication used in the treatment of certain advanced cancers e.g. kidney, soft tissue.

Pazopanib - Side Effects, Precautions, and Contraindications

What side effects can Pazopanib cause?

  • Nausea, decreased appetite
  • Diarrhea and/or abdominal pain
  • Discoloration of skin and hair
  • Increased risk of bleeding or bruising
    Inform your doctor if you have any surgery planned.
  • High blood pressure
    Monitor your blood pressure closely.
  • Tiredness and lack of energy

Inform your doctor if any of the following occurs:

  • Rapid or irregular heartbeat, or chest pain
  • Sudden onset of cough or shortness of breath
  • Unusual swelling of hands or feet
  • Yellowing of the eyes or skin, dark tea-colored urine
  • Prolonged bleeding or bruising, poor healing wounds
  • Severe headache, unusual weakness, tiredness or light-headedness
  • Severe diarrhea or abdominal pain
  • Signs of infection – fever of 38°C or higher, chills, sore throat, pain or difficulty urinating
    To minimize infection risk, avoid crowds or being near people with injection.

Before taking Pazopanib, what precautions must I follow?

  • Use effective birth control during treatment and for 2 weeks after stopping Pazopanib. Inform your doctor if you or your partner plan for or suspect pregnancy.
  • Do not take any medication and supplements without medical supervision.
  • Inform your doctor or pharmacist if you have any other medical conditions e.g. heart problems, high blood pressure, adrenal insufficiency, diabetes.

What food or medicine must I avoid when I take Pazopanib?

  • Grapefruit and its juice.

Pazopanib - Dosage and How to Use

How should Pazopanib be used?

It is a tablet, taken by mouth once daily and swallowed whole with water. Take the exact number of tablets instructed by your doctor.
Take on an empty stomach i.e. at least 1 hour before or 2 hours after food.

What should I do if I miss a dose?

​If you miss a dose of Pazopanib, take it as soon as you can if it is within 12 hours of the missed dose. However, if more than 12 hours have passed, skip the missed dose and go back to your usual dosing time. Do not double dose.

What should I do if I overdose?

​If you overdose on this medication, inform your doctor immediately.

Pazopanib - Handling and Storage

How should I handle Pazopanib safely?

Do not break or crush the tablet.

How should I store Pazopanib?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Pazopanib safely?

Pazopanib - Additional Information

  • Updated on Friday, March 1, 2019
  • This article is contributed by Department of Pharmacy National Cancer Centre Singapore

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