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Methotrexate (Non-Cancer)

Drug Class: Commonly Known As: Category:
Immune Suppressant Adult

Methotrexate (Non-Cancer) - What is it for

  • Methotrexate belongs to a class of medications called disease modifying anti-rheumatic drugs (DMARDs which can modify the progress of clinical disease by reducing permanent damage to joints caused by continuing inflammation. 
  • It blocks the formation of deoxyribonucleic acid (also known as DNA), which is important for developing cells, such as those in the immune system. However, it is not completely clear how this medication works in rheumatoid arthritis. 
  • In the long term, Methotrexate reduces permanent damage to the organs such as the joints and skin. 
  • It may be used on its own or in combination with other DMARDs or biologic agents.
  • Methotrexate is also used in non-autoimmune diseases. It is not within the scope of this material to cover information for such conditions. 
  • This material provides information for people being treated with low dose Methotrexate (25 milligrams or less per week). 
  • Updated on 12/31/2022 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

This leaflet answers some common questions about Methotrexate. It does not contain all the available information. It also does not take the place of talking to your doctor or pharmacist.

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