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Oral JAK Inhibitors
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Oral JAK Inhibitors
Oral JAK Inhibitors
Drug Class:
Commonly Known As:
Category:
Oral JAK Inhibitors
Oral JAK Inhibitors - What is it for
Oral JAK Inhibitors
Uses
Abrocitinib
Atopic eczema
Baricitinib
Atopic eczema, rheumatoid arthritis
Tofacitinib
Rheumatoid arthritis, psoriatic arthritis and ulcerative colitis
Upadacitinib
Atopic eczema, rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
This group of medications can also be used for other conditions, including the management of certain hair conditions.
Oral JAK Inhibitors - Side Effects, Precautions, and Contraindications
What side effects can Oral JAK Inhibitors cause?
Common side effects include:
Symptoms of a common cold (blocked nose, runny nose, sneezing, sore throat, coughing, mild fever (below 38°C)
Blister-like rashes, shingles
See a doctor immediately.
Nausea/vomiting, stomach upset, diarrhea
Increase in cholesterol levels and amount of triglycerides (fats) in your blood
Acne
Headache
Abrocitinib: Dizziness
Rare but serious side effects include:
Side effects
Warning signs
Allergic reaction
rash
swollen face/eyes/ lips/tongue
difficulty breathing
Infection
burning sensation/pain on urination
fever more than 38°C
chills
feeling very tired
persistent cough
very bad sore throat
wounds that will not heal
mouth sores
Increase in muscle enzymes
dark urine
muscle pain
Liver problems
dark urine
feeling very tired
lack of appetite
persistent abdominal pain
light-colored stool
yellow skin or eyes
Stomach problems (applicable to Baricitinib, Tofacitinib and Upadacitinib only)
severe stomach pain
blood in the stool
change in bowel habits
Heart problems, stroke, blood clots
severe stomach pain
blood in the stool
change in bowel habits
Heart problems, stroke, blood clots
breathlessness
chest pain or tightness
unusual pain or discomfort in your arms, back, neck, jaw or stomach
weakness in 1 part or side of your body
slurred speech
drooping on 1 side of your mouth
red, painful or swollen leg or arm
Abrocitinib: symptoms of high blood pressure (severe headache, change in eyesight, passing out)
Blood disorders
Low red blood cell count
Low white blood cell count
Transient low platelet count e.g., unusual bleeding or bruising (Abrocitinib)
Cancer or malignancy
change in color or size of a mole
a skin lump or growth
unexplained weight loss
loss of appetite
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Before taking Oral JAK Inhibitors , what precautions must I follow?
Inform your healthcare professional if:
You have severe infections (e.g., tuberculosis, shingles, fungal or bacterial or viral infections) or have immune system problems
You have stomach problems or intestinal disease
You have kidney problems
You have liver problems
You have lung problems
You have personal or family history of heart problems, high blood pressure, stroke and/or blood clots
You have any personal or family history of cancer
You are pregnant or planning to become pregnant
You are breast-feeding
You are a current or past smoker
You have any allergies
You have been given Abrocitinib but have lactose allergy, galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. (Abrocitinib contains lactose)
Blood tests and other tests will be done before and while on this medication to decide if it is suitable for you, as well as to monitor for side effects.
Do not allow anyone else to take this medication.
What food or medicine must I avoid when I take Oral JAK Inhibitors ?
Inform your doctor if you are taking any other medications (especially blood thinners e.g., aspirin (>81mg/day) during the first 3 months of Abrocitinib), over-the-counter medications, including vitamin and mineral supplements, and herbal products.
Consult your doctor or pharmacist before immunizations (vaccinations) as this medication may either raise the chance of an infection or reduce the effectiveness of the vaccine.
Avoid crowded places and consumption of raw or undercooked food (e.g., half-boiled eggs) while on this medication as it may reduce the ability of your body to fight against infection.
Oral JAK Inhibitors - Dosage and How to Use
How should Oral JAK Inhibitors be used?
This medication may be taken with or without food.
You may take the medication with food if you have nausea/vomiting or stomach upset.
This medication has to be taken regularly to obtain the full benefits of the medication. It may take weeks to months for an effect to be seen.
What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not double the next dose to make up for the missed dose.
What should I do if I overdose?
Oral JAK Inhibitors - Handling
How should I handle Oral JAK Inhibitors safely?
Oral JAK Inhibitors - Storage
How should I store Oral JAK Inhibitors ?
;#Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#
How should I dispose of Oral JAK Inhibitors safely?
Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.
Oral JAK Inhibitors - Additional Information
What Oral JAK Inhibitors treats
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