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Denosumab

Drug Class: Commonly Known As: Category:
Anti-RANKL Monoclonal Antibody Xgeva®, Prolia® Adult, Cancer-related

Denosumab - What is it for

Denosumab is a medication given to reduce bone breakdown, thus lowering the risk of broken bones or cancer-related bone pain.

It is available in two brands, with different uses. Do not use the two brands interchangeably unless otherwise instructed by your doctor.

Xgeva® is used to treat giant cell tumor of bone or  conditions where cancer has spread to the bone.

Prolia® is used to treat or prevent osteoporosis.

Denosumab - Side Effects, Precautions, and Contraindications

What side effects can Denosumab cause?

  • Muscle, back, bone or joint pain
  • Nausea or vomiting
  • Constipation or diarrhea
  • Slight tiredness
  • Increased cholesterol levels
  • Inform your doctor if any of the following occurs:
  • Excessive muscle cramping
  • Giddiness or confusion
  • Excessive skin dryness, irritation or rashes
  • Chest pain or shortness of breath
  • Fever, pain upon urination, gum pain or gum bleeding
  • Severe nausea or vomiting or abdominal pain
  • Allergic reaction e.g. rash, swelling of eyelids and face

Before taking Denosumab, what precautions must I follow?

  • Ensure you are taking enough calcium and vitamin D daily, unless otherwise instructed by your doctor.
  • Maintain good oral hygiene. Inform your dentist that you are on Denosumab.
  • For women: Use effective birth control and inform your doctor if you intend to get pregnant or breast-feed. 

What food or medicine must I avoid when I take Denosumab?

Denosumab - Dosage and How to Use

How should Denosumab be used?

Denosumab is an injection given under the skin (subcutaneously) at the upper arm, upper thigh or abdomen.

The interval between each injection you receive depends on what you are being treated for. Your doctor will inform you accordingly.

Do not shake the vial or syringe vigorously.

What should I do if I miss a dose?

If you miss a dose, receive it as soon as possible by rescheduling an administration date with your clinic.

What should I do if I overdose?

Denosumab - Handling and Storage

How should I handle Denosumab safely?

How should I store Denosumab?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store in the refrigerator. Do not freeze.;#

How should I dispose of Denosumab safely?

Denosumab - Additional Information

  • Updated on Wednesday, March 6, 2019
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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