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Ceritinib

Drug Class: Commonly Known As: Category:
Anaplastic Lymphoma Kinase (ALK) Tyrosine Kinase Inhibitor Zykadia® Cancer-related

Ceritinib - What is it for

​Ceritinib is a targeted medication used in the treatment of advanced non-small cell lung cancer with ALK gene mutation.

Ceritinib - Side Effects, Precautions, and Contraindications

What side effects can Ceritinib cause?

  • Nausea and vomiting
  • Decreased appetite
    Take small frequent meals instead of 3 main meals a day to help with your food intake.
  • Diarrhea or constipation
  • Abdominal pain
  • Tiredness and lack of energy

Inform your doctor if any of the following occurs:

  • Sudden onset of cough, chest pain or shortness of breath with fever
  • Yellowing of the skin or eyes or dark tea-colored urine
  • Frequent thirsts, urination, giddiness and feeling hungry
  • Slow or abnormal heartbeat
  • Unusual weakness, tiredness, light-headedness or dizziness
  • Severe abdominal pain, nausea, vomiting or diarrhea

Before taking Ceritinib, what precautions must I follow?

  • Use effective birth control during treatment and after stopping Ceritinib for at least:
    • 6 months (for women)
    • 3 months (for men
      Inform your doctor if you or your partner plan for or suspect pregnancy.
  • Do not take any medication and supplements without medical supervision.
  • Inform your doctor or pharmacist if you have any other medical conditions e.g. diabetes, heart disease.

What food or medicine must I avoid when I take Ceritinib?

​Avoid taking grapefruit and its juice when you are on Ceritinib.

Ceritinib - Dosage and How to Use

How should Ceritinib be used?

​Ceritinib is to be taken by mouth once daily, at the same time each day. Take the exact number of capsules as advised by your doctor. Swallow whole.

Follow your doctor's instruction on whether to take with or without food.

What should I do if I miss a dose?

If you miss a dose of Ceritinib, take it as soon as you can if it is within 12 hours of the missed dose. However if more than 12 hours have passed, skip the missed dose and go back to your usual dosing time. Do not double dose.

What should I do if I overdose?

​If you overdose on this medication, inform your doctor immediately.

Ceritinib - Handling and Storage

How should I handle Ceritinib safely?

Do not chew, open or crush the capsule.

How should I store Ceritinib?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Ceritinib safely?

Ceritinib - Additional Information

  • Updated on Thursday, February 21, 2019
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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