Abemaciclib

• ​Diarrhea
• Drink plenty of clear fluids to replace those lost (two litres everyday)
• Avoid oily or spicy food and milk or daily products
• Take the anti-diarrheal medication (e.g. Loperamide) that the doctor gives you when necessary
• Nausea and vomiting
• Take small, frequent meals throughout the day
• Stomach discomfort and decreased appetite
• Rash
• Avoid taking hot showers
• Hair loss
• Use a gentle shampoo to wash your hair
• Feeling tired and lack of energy
• Do not drive or operate machinery when you feel tired
• Decreased white blood cells, red blood cells and platelets
• This may put you at a higher risk of infections, bleeding or bruising and feeling tired
• To reduce your risk of infection:
• Avoid crowds and people who are sick. Wear a face mask when you go out.
• Wash your hands after using the toilet and before handling food
• Eat food that is fresh and completely cooked, and avoid raw or half-cooked food
• To reduce your risk of bleeding problems:
• Be careful when using sharp objects such as knives
• Use a soft bristle toothbrush to brush your teeth gently as your gums may bleed more easily
• Apply direct pressure to any cuts or wounds to help stop bleeding

• Very bad diarrhea that does not go away even after taking anti-diarrheal medications
• Signs of infection - fever of 38°C and above, chills, cough, sore throat, pain or burning feeling on passing urine
• Unusual bleeding, bruising, black sticky stools or blood in urine
• Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin
• Fast or irregular heartbeat, chest discomfort or if you feel faint, lightheaded, or dizzy
• Cough with chest pain or breathing difficulty
• Signs of blood clot e.g. warmth, pain or redness with swelling on arm or leg
  
• Symptoms of a drug allergy including one or more of the following:
• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body

​Inform your healthcare professional if:

• You are allergic to this medication
• You or your partner becomes pregnant or plans for pregnancy
• You should use effective birth control during and for three weeks after stopping treatment
• You are breastfeeding
• Do not breastfeed during treatment and for at least three weeks after the last dose of treatment
• You are taking or intend to take any other medications, including supplements, traditional medications and herbal remedies

​Avoid taking grapefruit or grapefruit juice when you are taking Abemaciclib as it may interact with your medication and increase the risk of side-effects.

• ​Take Abemaciclib two times a day
• You may take it with or without food
• Do not break, chew or crush the tablet. Swallow the tablet whole.
• Inform your doctor or pharmacist if you have difficulty swallowing

​If you forget to take a dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time to make up for the missed dose.

​Pack Abemaciclib into a bag and bring it back to the pharmacy where you received the medication from.