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Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) - Symptoms

​Depending on the location and extent of the abnormal protein infiltration, initial symptoms and presentation may vary. In the early disease stage, patient may not have many symptoms. As protein accumulates in the heart muscle causing it to become stiff and thick, patients can gradually develop symptoms such as difficulty breathing (especially on walking or lying flat), leg or abdominal swelling, reduced stamina and fatigue. If the misshapen protein accumulates on the conduction system of the heart, irregular heart rhythm or excessively slow heartbeat may occur. This may cause the patient to feel giddy, faint or have palpitations. 

Deposition of protein onto the tendons may cause backaches, numbness of hand and legs. If the nerve gets affected, patient may experience tingling sensation or pain in the feet as well. Some patients develop loss of weight and bloating. Foamy urine can also occur if the abnormal protein deposits in the kidneys.

Overall, symptoms may be non-specific and common to many other disease conditions. This may have contributed to underdiagnosis of ATTR-CM.  

In summary, the symptoms for ATTR-CM may include:

  • Difficulty breathing, especially when walking or lying flat
  • Fatigue
  • Legs or abdominal swelling
  • Giddiness or fainting episodes
  • Sensation of irregular heartbeat/palpitations
  • Numbness of hands and feet
  • Pain or numbness in the lower back and legs 
  • Foamy or frothy urine
  • Unexplained loss of weight

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) - Preparing for surgery

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) - Post-surgery care

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth