Li-Fraumeni Syndrome

How is LFS inherited?

LFS follows a dominant inheritance pattern. This means that individuals who have one faulty copy of the TP53 gene have an increased risk of cancer. It can affect both males and females.

Everyone has 2 copies of each gene in their body’s cells:

• 1 copy comes from our father
  
• 1 copy comes from our mother

A parent with a faulty gene(s) has a 50% chance of passing down their faulty gene(s) to their children. A child, sibling or parent of a family member with a faulty gene(s) has a 50% chance of also inheriting the same faulty gene(s). Extended relatives may also inherit the faulty gene(s).