Sorafenib

Uses

Precaution

Side Effects

Handling

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Uses

What is Sorafenib for?

Sorafenib is a medicine used in the treatment of Advanced Renal Cell Carcinoma, Hepatocellular Carcinoma and Differentiated Thyroid Carcinoma.

How should I take or use Sorafenib?

It is a tablet taken by mouth, with a glass of water. It should be taken on an empty stomach i.e. at least 1 hour before or 2 hours after a meal. Take the exact number of tablets and follow the dosing schedule as instructed by your doctor.

What should I do if I forget to take or use Sorafenib?

If you miss a dose of Sorafenib, take it as soon as you can if it is within 6 hours of the missed dose. If it is over 6 hours since your missed dose, skip the missed dose and go back to your usual dosing time. Do not double the dose.

Precaution

What precautions should I take when taking or using Sorafenib?

Effective birth control measures for both men and women are recommended during treatment and for at least 2 weeks after stopping treatment. Inform your doctor if you suspect you are or intend to get pregnant.
Inform your doctor or pharmacist if you:

Are on any medicines e.g. warfarin
Have any other medical conditions e.g. heart problems, high blood pressure

Side Effects

What are some common side effects of Sorafenib?

Rash, redness, dryness or itching of your skin
Numbness, tingling or unusual sensation in palms of hands or soles of feet
Diarrhea and/or stomach pain may occur
Gum bleeding
High blood pressure
Your blood pressure should be monitored closely. Discuss a proper follow-up plan with your doctor.

Inform your doctor if any of the following occurs:

Ulceration, blistering, pain or swelling of the hands or feet
Prolonged gum bleeding or bleeding on other parts of the body
Chest pain or irregular heartbeat
Severe diarrhea
Severe headache or dizziness
Allergic reactions like rashes, swelling or breathing difficulties

Handling

How should I store Sorafenib?

Keep away from children
Keep in a cool, dry place, away from direct sunlight
Store at room temperature

How should I handle Sorafenib safely?

Do not break or crush the tablets.

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What should I do if I overdose?

If you overdose on this medicine, inform your doctor immediately.

Disclaimers

Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System, and SingHealth), community pharmacies (Guardian, Unity, and Watsons), and the Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.