Oral JAK Inhibitors

What is Oral JAK Inhibitors for?

This group of medications can also be used for other conditions, including the management of certain hair condition.

How should I take or use Oral JAK Inhibitors?

• This medication may be taken with or without food.
• You may take the medication with food if you have nausea/vomiting or stomach upset.
• This medication has to be taken regularly to obtain the full benefits of the medication. It may take weeks to months for an effect to be seen.

What should I do if I forget to take or use Oral JAK Inhibitors?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not double the next dose to make up for the missed dose.

What precautions should I take when taking or using Oral JAK Inhibitors?

• Inform your healthcare professional if:
  • You have severe infections (e.g., tuberculosis, shingles, fungal or bacterial or viral infections) or have immune system problems
  • You have stomach problems or intestinal disease
  • You have kidney problems
  • You have liver problems
  • You have lung problems
  • You have personal or family history of heart problems, high blood pressure, stroke and/or blood clots
  • You have any personal or family history of cancer
  • You are pregnant or planning to become pregnant
  • You are breast-feeding
  • You are a current or past smoker
  • You have any allergies
  • You have been given Abrocitinib but have lactose allergy, galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. (Abrocitinib contains lactose)

• Blood tests and other tests will be done before and while on this medication to decide if it is suitable for you, as well as to monitor for side effects.

• Do not allow anyone else to take this medication.

What food or medication should I avoid when I take or use Oral JAK Inhibitors?

• Inform your doctor if you are taking any other medications (especially blood thinners e.g., aspirin (>81mg/day) during the first 3 months of Abrocitinib), over-the-counter medications, including vitamin and mineral supplements, and herbal products.

• Consult your doctor or pharmacist before immunizations (vaccinations) as this medication may either raise the chance of an infection or reduce the effectiveness of the vaccine.

• Avoid crowded places and consumption of raw or undercooked food (e.g., half-boiled eggs) while on this medication as it may reduce the ability of your body to fight against infection.

What are some common side effects of Oral JAK Inhibitors?

If any of the following side effects persist or are severe, you should consult your doctor.

• Symptoms of a common cold (blocked nose, runny nose, sneezing, sore throat, coughing, mild fever (below 38°C)
• Blister-like rashes, shingles
  • See a doctor immediately.
• Nausea/vomiting, stomach upset, diarrhea
• Increase in cholesterol levels and amount of triglycerides (fats) in your blood
• Acne
• Headache
• Abrocitinib: Dizziness

What are some rare but serious side effects that I need to seek medical advice immediately?

How should I store Oral JAK Inhibitors?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.

How do I throw away Oral JAK Inhibitors safely?

Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.