Naphcon-A® is a combination eye drop that contains two active ingredients: naphazoline hydrochloride (a vasoconstrictor) and pheniramine maleate (an antihistamine).
This medication is used to relieve eye irritation, redness, and itching caused by allergic conjunctivitis. Allergic conjunctivitis is a condition that affects the eyes, and this usually happens when your eyes are exposed to allergens (particles that can cause allergic reactions), of which they may become irritated, red, itchy and watery.
The vasoconstrictor works by narrowing the blood vessels in the eye to reduce redness, while the antihistamine helps to relieve itching and other allergic symptoms.
This medication may be used when required for a short period of time. This means that you do not have to use them if you do not have any symptoms.
Inform your healthcare professional if:
If you have any question about this medication, please discuss with your healthcare professional.
Inform your doctor if you are taking Monoamine Oxidase Inhibitors (MAOIs), medications to treat Parksinson’s disease (such as Selegiline, Rasagiline) or mental health conditions (such as Moclobemide) as this may increase the risk of side effects.
The side-effects listed here are mild and will subside after some time. Do not drive or operate machinery until your vision clears. Speak with your healthcare professionals if any of these continues, worsens, or affects your daily life.
Do not use this medication for more than three consecutive days unless directed by your doctor, as prolonged use may worsen eye redness.
The symptoms of a drug allergy include one or more of the following:
You can also find out about drug allergies by watching these videos:
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Other serious side effects may include:
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children. Discard unused opened bottle 4 weeks after opening.
Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.
Discard this medication 4 weeks after opening.
Disclaimers
Please take note that the above is not a complete list of all possible side-effects. If you have any concerns about your medication or if you have other side-effects that you think are caused by this medication, please consult your doctor or pharmacist. If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last Updated on June 2026
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