Methotrexate is a medicine that reduces over-activity of the immune system. It is used to treat various autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus (SLE), juvenile idiopathic arthritis, psoriasis, psoriatic arthritis, uveitis, and inflammatory myositis (muscle inflammation).
In arthritis, methotrexate acts as a disease modifying anti-rheumatic drug (DMARD) that helps to reduce pain, swelling, and long-term joint damage.
A typical weekly dose of methotrexate ranges from 7.5mg to 25mg, given in the form of tablets or injection. Dosage may vary depending on your disease activity and response to the medicine.
Tablets should be taken with or after food. It should be swallowed whole with a glass of water, without chewing or crushing. Wash hands thoroughly after administration.
Folic or folinic acid (also called folate) is often given to reduce the risk of some side effects. It is usually taken a day before or after methotrexate unless advised otherwise by your doctor.
The beneficial effects of methotrexate will begin after 6 weeks and the full benefits may not be seen until after 12 weeks of treatment. Thus, it is important that you take your medication regularly, otherwise you may not benefit at all.
Medications, such as corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs) and other DMARDs may be taken with methotrexate.
If you miss a dose, take it as soon as you remember if it is within 2 days from your scheduled dose. For example, if your scheduled dose is on Sunday and you remember your forgotten dose on Tuesday, take the dose on Tuesday and resume the Sunday schedule in the same week. Skip the dose if 3 or more days have lapsed since the missed dose. Do not take double doses to make up for the missed dose.
Inform your healthcare professional if:
Conception and breastfeeding precautions:
Consult your doctor immediately if you experience any of the following side effects:
The symptoms of a drug allergy include one or more of the following:
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.
Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.
Empty blisters may be packed and sealed in a plastic bag before throwing it into the rubbish chute or bin. For unused medications, return to the pharmacy for proper disposal.
Disclaimers
If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.
This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.
Last updated on Jun 2022
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