Maviret (Glecaprevir and Pibrentasvir)

What is Maviret (Glecaprevir and Pibrentasvir) for?

This is an antiviral medicine used to treat long-term (‘chronic’) hepatitis C (an infectious disease that affects the liver, caused by the hepatitis C virus), by stopping the hepatitis C virus from multiplying and infecting new cells. This allows the virus to be removed from the body.

How should I take or use Maviret (Glecaprevir and Pibrentasvir)?

• Do not stop taking the medication without checking with your healthcare professional.
• This medicine should be taken with food.
• Swallow the tablets whole or cut in half.
• Do not chew, crush or break the tablets
• If you vomit less than 3 hours after taking the medication, take another dose.
• If you vomit more than 3 hours after taking the medication, you do not need to take another dose until your next scheduled dose

What should I do if I forget to take or use Maviret (Glecaprevir and Pibrentasvir)?

If you notice this happened within 18 hours of the time you usually take the medication, take the dose as soon as possible, and take the next dose at your usual time. If you notice this happened 18 hours or more after the time you usually take the medication, wait and take the next dose at your usual time. Do not take a double dose (i.e two doses too close together).

What precautions should I take when taking or using Maviret (Glecaprevir and Pibrentasvir)?

Inform your healthcare professional if:

• You are allergic to this medication or any of the other ingredients of this medication
• You are pregnant, planning to become pregnant, or breastfeeding (remove if not needed)
• You have liver problems other than hepatitis C
• You have HIV infection
• You have a current or previous infection with the hepatitis B virus
• You have had a liver or kidney transplant
• You have a history of diabetes

What food or medication should I avoid when I take or use Maviret (Glecaprevir and Pibrentasvir)?

This medication may cause significant changes to the effects of other medications that you may be taking. Conversely, there are medications that can cause significant changes to the effects of this medication. You should therefore avoid such associated medications, or that dosing of these medications need to be adjusted. Consult your healthcare professionals for further advice on the suitability of this medication with your other medications

What are some common side effects of Maviret (Glecaprevir and Pibrentasvir)?

• Feeling very tired (fatigue), weak or lack of energy
• Headache
• Nausea, diarrhoea

What are some rare but serious side effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following:

• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body

Some of these side effects include:

• Liver problem: Signs include dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately

How should I store Maviret (Glecaprevir and Pibrentasvir)?

Store in a cool and dry place, away from direct sunlight. Keep this medication away from children.

How do I throw away Maviret (Glecaprevir and Pibrentasvir) safely?

Pack the medication into a bag and bring it back to the pharmacy where you received the medication from.