imipramine

Apo-Imipramine


Uses


What is Imipramine (Nocturnal Enuresis) for?

Imipramine is a tricyclic antidepressant used to treat a condition called nocturnal enuresis (bed-wetting at night). It helps the bladder muscle to relax, while causing the smooth muscles at the bladder neck to contract, therefore increasing the ability to hold urine in the bladder.

It can also be used to treat symptoms of depression (low mood).

This medication may also be used for other conditions. Check with your healthcare professional if you are unsure why you are given this medication.

How should I take or use Imipramine (Nocturnal Enuresis)?

  • Do not stop taking your medication without checking with your healthcare professional.
  • You may take this medication with or without food.
  • It is taken once daily, preferably one hour before bedtime.

What should I do if I forget to take or use Imipramine (Nocturnal Enuresis)?

If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.


Precaution


What precautions should I take when taking or using Imipramine (Nocturnal Enuresis)?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding
  • You have heart, liver or kidney problems
  • You have diabetes as this medication may affect blood glucose control
  • You have a history of seizures(fits)
  • You have glaucoma
  • You are taking other medications for your mood
  • You have sudden changes in mood
  • You have new or increasing thoughts of harming yourself
   IMPORTANT: 
       In some cases, particularly in young people below the age of 25 years, this medication may cause the      following changes to a person's mental condition, especially in the first few weeks of treatment or during dose 
 changes 
  • New or worsening thoughts of harming yourself or ending your life 
  • Worsening agitation, restlessness, violent behaviour, or 
  • Other changes in mood or behaviour 
   Please inform your doctor as soon as possible, or for your family or caregiver to inform your doctor if 
   you are unable to seek treatment on your own 

  Do not stop taking this medication on your own without discussing with your doctor.

   It is important to note that your doctor has prescribed this medication as he/she feels you will benefit 
   more from taking this medication over the possible risks that it may cause, which have a low chance of 
   occuring, and most people take this medication without any of such problems.  


What food or medication should I avoid when I take or use Imipramine (Nocturnal Enuresis)?

Avoid drinking alcohol as it may increase the risk of dizziness, light-headedness or drowsiness.

Inform your healthcare professional if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies.


Side Effects


What are some common side effects of Imipramine (Nocturnal Enuresis)?

  • Nausea
    • Take the medication after food, eat small but frequent meals. Avoid fatty or spicy food.
  • Drowsiness
    • May affect your ability to drive and use machinery. Make sure your reactions are normal before you drive or do things which require you to be alert.
  • Dizziness
    • Get up slowly from a sitting or lying position.
  • Dry mouth
    • Chew sugar-free gum, suck on sugar-free hard candies or ice chips, sip water regularly
  • Constipation
    • Drink more water (if you do not have any fluid restrictions), eat more high-fibre foods, and exercise regularly
  • Dry Eyes
    • Apply lubricant eye drops if necessary.
  • Skin sensitive to sunlight
    • Wear long-sleeved clothing and apply sunblock to protect yourself from the sun.

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

Very rarely (affect less than 1% of patients), this medication may cause:

  • Fast or irregular heartbeat
  • Confusion
  • Hallucinations (seeing or hearing things that are not there)
  • Stiffness of arms or legs
  • Problems in urinating
  • Blurred vision
  • Seizures (fits)
  • Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.


Handling


How should I store Imipramine (Nocturnal Enuresis)?

  • Keep away from children
  • Keep in a cool, dry place, away from direct sunlight

How do I throw away Imipramine (Nocturnal Enuresis) safely?

Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Disclaimers

Please take note that the above is not a complete list of all possible side effects. If you have any concerns about your medication or if you have other side effects that you think are caused by this medication, please consult your doctor or pharmacist.

If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (National Healthcare Group, National University Health System, and SingHealth), community pharmacies (Guardian, Unity, and Watsons), and the Pharmaceutical Society of Singapore. The content does not reflect drug availability and supply information in pharmacies and healthcare institutions. You are advised to check with the respective institutions for such information.

Last Updated on September 2019



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