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How to inject pre-filled syringe/pen subcutaneously

A pre-filled syringe or pre-filled pen is a ready-to-use device that contains a fixed amount of medication. It is designed to allow you to inject the medication subcutaneously (into the fatty tissue under the skin).

This article will explain how to inject a pre-filled syringe or pre-filled pen subcutaneously on a step-by-step basis.

Using a Pre-filled Pen
Preparation

Step 1: Wash your hands thoroughly with soap and water, then wipe them dry.

Step 2: Check the medication in the pen. Depending on the medication, it should appear either clear and colourless, or contain particles. Do not use it if it looks unusual (e.g. discoloured, cloudy when it should be clear, or contains particles when it should not). 

If your medication requires mixing, gently roll the pen between your palms or slowly turn it upside down and back a few times as instructed. Do not shake the pen. Check with your healthcare professional if you are unsure.

Step 3: If your medication needs to be stored in the refrigerator, take it out and allow it to reach room temperature to reduce discomfort during injection.

Step 4: If your pen requires a needle to be attached, wipe the tip of the pen with an alcohol swab and allow it to dry before attaching the needle. Remove the protective cap and attach the needle securely to the pen.

Note: Some pens come with a needle already attached. Please check the instructions for your specific pen or ask your healthcare professional.

Step 5: If your pen requires a flow check, turn the dial to the priming amount as instructed, then press the injection button. You should see a small drop of medication appear at the needle tip, confirming the pen is working correctly and the needle is not blocked.

Note: Not all pens require this step. Please check the instructions for your specific medication or ask your healthcare professional.

Step 6: Turn the dial to your prescribed dose as instructed by your healthcare professional.

Step 7: Choose an injection site (stomach, thigh, upper arm, or buttocks) and clean it with an alcohol swab.

Step 8: If injecting into the stomach area, inject at least 2 finger-widths away from the belly button. Avoid skin that is irritated, bruised, scarred, or has lumps.

Administration

Step 1: Sit or lie down in a comfortable and relaxed position.

Step 2: Using your thumb and index finger, gently pinch the skin at the injection site to create a skin fold.

Step 3: Insert the needle straight into the skin fold at a right angle (90 degrees).

Step 4: Press the injection button slowly and hold it down until all the medication has been injected. You may hear or feel a click depending on your pen.

Note: Depending on your medication, you may need to either release the skin fold before pressing the injection button, or maintain the skin fold throughout. Please check the instructions for your specific medication or ask your healthcare professional.


Different medications may have different recommended storage conditions. Refer to the specific medication article for recommended storage conditions.

Different medications may have different recommended ways to be disposed of. Refer to the specific medication article for recommended ways to dispose of this medication.

Disclaimers

The content of this article does not replace the information from your healthcare professional. Please consult your healthcare professional for more information.

This article is jointly developed by members of the National Medication Information workgroup. The workgroup consists of cluster partners (NHG Health, National University Health System and SingHealth), community pharmacies (Guardian, Unity and Watsons) and Pharmaceutical Society of Singapore.

Last Updated on October 2026



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