Fexofenadine/Pseudoephedrine

What is Fexofenadine/Pseudoephedrine for?

Fexofenadine and Pseudoephedrine are used in combination for the symptoms of a cold/flu or allergy. Fexofenadine helps to relieve sneezing, runny and itchy nose and/or eyes, while Pseudoephedrine helps to relieve blocked nose. This medication comes in the form of slow-release tablets that last for 12 hours. 

How should I take or use Fexofenadine/Pseudoephedrine?

• Take this medication when necessary to relieve your symptoms.
• Do not take more than the dose recommended by your healthcare professional.
• Do not use in children under 12 years old.
• Take this medication at least 2 hours before or after meals.  
• Swallow this medication whole. Do not chew, cut or crush the medication. 

What should I do if I forget to take or use Fexofenadine/Pseudoephedrine?

• This medication may be taken when required for a short period of time. This means that you may stop taking the medication when you no longer have symptoms.
• If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue normally. Do not take two doses or extra medication to make up for the missed dose.

What precautions should I take when taking or using Fexofenadine/Pseudoephedrine?

Inform your healthcare professional if:

• You are allergic to this medication or any of the other ingredients of this medication.
• You are pregnant, planning to become pregnant, or breastfeeding.
• You are taking any other medications, including supplements, traditional medications, and herbal remedies.
• You have:
  • High blood pressure
  • Heart disease or abnormal heart rhythm
  • Hyperthyroidism (overactive thyroid gland)
  • Diabetes
  • Glaucoma (high eye pressure)
  • Stomach ulcers
  • Blockage of intestines
  • Prostate or bladder problems
  • Liver or kidney problems

If you have any questions about this medication, please discuss with your healthcare professional.

Signs that your condition may require further medical attention include:

• Symptoms continuing for more than 2 weeks even with self-treatment
• Blood in your phlegm or mucus
• Loss of weight, even though you are not trying to do so
• Keep feeling tired
• Drenching night sweats

If you experience any of these symptoms, please consult a doctor. 

What food or medication should I avoid when I take or use Fexofenadine/Pseudoephedrine?

• Do not take this medication with, or within 14 days of stopping, medications known as monoamine oxidase inhibitors (e.g. moclobemide and selegiline).
• The following affects the absorption of Fexofenadine into your body:
  • Fruit juices, especially grapefruit, orange or apple juice
    • Take this medication at least 4 hours apart from fruit juices.
  • Food that is high in fat
    • Take this medication at least 2 hours apart from meals.
  • Antacids that contains aluminum or magnesium
    • Take this medication at least 2 hours apart from these antacids.

Inform your healthcare professional if you are taking any other medicines, including over-the-counter medications. Many over-the-counter medications have overlapping effects with this medication. To prevent overdosing, always check with your healthcare professional before taking two over-the-counter medications at the same time. 

What are some common side effects of Fexofenadine/Pseudoephedrine?

• Trouble sleeping
  • Avoid taking too close to your sleep time.
• Restlessness
• Dry mouth, skin and eyes
  • Drink more water or suck an ice cube to help with mouth dryness.
  • Use lubricant eye drops to relieve eye dryness.
• Headache
• Dizziness
• Stomach disturbances such as
  • Diarrhoea
  • Vomiting
    • You may consume smaller but more frequent meals, and avoid spicy, fatty food, to reduce the risk of vomiting.

These side effects may be temporary and reversible. If they are persistent and become bothersome, please speak to your healthcare professional. 

What are some rare but serious side effects that I need to seek medical advice immediately?

The symptoms of a drug allergy include one or more of the following:

• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

You can also find out about drug allergies by watching these videos:

They are available in English, 中文, Melayu and தமிழ்: Drug Allergies

Rarely, this medication may cause the following symptoms:

• A sudden and very bad headache
• Nausea and/or vomiting  
• Confusion
• Seizures (fits)
• Changes in vision

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately. 

How should I store Fexofenadine/Pseudoephedrine?

Store in a cool and dry place away from direct sunlight. Keep this medication away from children. 

How do I throw away Fexofenadine/Pseudoephedrine safely?

Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.