Assoc Prof Joanne Ngeow Yuen Yie

Dr Joanne Ngeow, MBBS, MRCP, MPH is Senior Consultant, Division of Medical Oncology at the National Cancer Centre Singapore and Associate Professor, Lee Kong Chian School of Medicine, Nanyang Technological University. Dr Ngeow currently heads the Cancer Genetics Service at the National Cancer Centre Singapore with an academic interest in hereditary cancer syndromes and translational clinical cancer genetics. She was awarded consecutive fellowships by the National Medical Research Council and the Ambrose Monell Foundation to complete formal clinical and bench training in Cancer Genomic Medicine at the Genomic Medicine Institute, Cleveland Clinic, Ohio. Dr Ngeow’s research focuses on understanding how a gene-environmental interaction predisposes to cancer initiation and progression. Her team seeks to identify, characterise and understand genes which cause susceptibility to traditional and complex heritable cancer syndromes, to determine their role in sporadic carcinogenesis. The Cancer Genetics Service led by Dr Ngeow is the go-to for clinical cancer genetics in Singapore and the region. Dr Ngeow is funded by the National Medical Research Council, Terry Fox Foundation and Lee Foundation. Her work is published in over 80 peer-reviewed top scientific journals and she is the recipient of consecutive scientific awards from the American Society of Clinical Oncology and Endocrine Society in recognition of her contributions to the field of cancer genomic medicine.

• PhD, Lee Kong Chian School of Medicine, Nanyang Technological University
• MPH, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA 
• FAMS, Fellow, Academy of Medicine Singapore (Medical Oncology)
• MMed, National University of Singapore 
• MRCP, Royal College of Physicians (UK) 
• MBBS (Hons), University of Melbourne
  

• Associate Professor, Lee Kong Chian School of Medicine, Nanyang Technological University
• Elected Chair, International Society for Gastrointestinal Hereditary Tumours (InSiGHT)
• Founding Chair, Inherited Cancers Network Asia (ICaN Asia) Life member, Asia Pacific Society of Human Genetics
• Fellow, Academy of Medicine, Singapore (Clinician Scientist)
• Member, European Society of Human Genetics 
• Member, F1000 
• Member, The Endocrine Society Member, American Association for Cancer Research 
• Member, American Society of Human Genetics 
• Fellow, Academy of Medicine, Singapore (Medical Oncology)

• National Medical Research Council Clinical Scientist Award (Senior Investigator), 2026
• Distinguished Team Award (Cancer Genetics Service), SingHealth Excellence Awards 2025
• National Medical Research Council Clinical Scientist Award (Investigator), 2021
• SkillsFuture Fellow Award, 2020
• National Medical Research Council Clinical Scientist Award (Investigator), 2017 SingHealth Publish! Award (Outstanding), 2016 
• Endocrine Society Early Investigator Award, ENDO, 2016 
• National Medical Research Council Transition Award, 2014 
• Excellence in Education Award, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, OH, USA, 2013 
• ASCO Merit Award, American Society of Clinical Oncology Annual Meeting, Chicago, IL, USA, 2013 
• ASCO Merit Award, American Society of Clinical Oncology Annual Meeting, Chicago, IL, USA, 2012
  

• Longitudinal Follow-Up of Hereditary Cancer Predisposition Carriers: Ongoing
• Understanding patient experience with genetic testing: Ongoing
• Ethical, Social and Insurance Issues in Precision Medicine: Ongoing
• Health-Services and Implementation Research in Cancer Genetics: Ongoing
• Cancer Screening Uptake and Behavioural Interventions: Ongoing
• Artificial Intelligence, Cancer Risk Prediction, and Risk-Modelling: Ongoing
• Molecular Mechanism of Cancer Predisposition: Ongoing
• Functional Genomics and Variant Classification: Ongoing
  

• Caeser, R., Low, D., Chia, I. Matchar D., Hartman M., Wang Y., Li J., Redekop R., Subramaniam T., Li STP., Wee HL, Cher GB, Virabhak S, PRECISE CIP Consortium, Seow SW, Chambers JC, Tan P, Tan ES, Ng KH, Ngeow J^. Building a Precision Health Ecosystem: Singapore’s Approach to Innovation through the Clinical Implementation Pilots. npj Genom. Med. (2026). (IF: 5.3)
• Soon JJH, Wu J, Ishak NDB, See WQ, Dorosan M, Yuen J, Tan AWL, Ong MEH, Lam SSW, Wee HL, Chiang J, Ngeow J^. Leveraging Electronic Health Records to Examine the Real-World Rates of Cancer Genetics Referrals in a Singapore Health Care Cluster. JCO Oncol Pract. 2026 Jan;22(1):91-99. PMID: 40233285. (IF: 4.7)
• Yuen J, Chua Z, Lim KSA, Rahadian RE, Ishak NDB, Li ST, Zhang Z, Chiang J, Ngeow J^. Understanding shared and sex-specific considerations in hereditary breast and ovarian cancer (HBOC) testing decision-making in Singapore. J Genet Couns. 2026 Jun;35(3):e70247. PMID: 42295046 (IF:1.9)
• Yuen J, Li ST, Courtney EK, Karthikeyan M, Scriven T, Binte Ishak ND, Goh HX, Lim T, Zhang Z, Chiang J, Kanesvaran R, Dent R, Ngeow J^. Inefficiencies in precision medicine: can genetic counsellors (GC) be the solution? The experience from the first GC-led cancer genetics service in Asia. J Med Genet. 2025 Nov 21;62(12):776-782. PMID: 40908109 (IF: 3.4)
• Nguyen T, Bora N, Ye J, Chong ST, Sutopo RC, Mu Y, Ngeow J^. In silico and in vitro mutational analysis to investigate the structure and pathogenicity of POT1 missense variants. NAR Mol Med. 2025 Mar 8;2(2):ugaf004. PMID: 41255705 (IF: 16.7)
• Que FVF, Ishak NDB, Li ST, Yuen J, Shaw T, Goh HX, Zhang Z, Chiang J, Yeo SY, Chew LL, Thng CH, Ngeow J^. Utility of Whole-Body Magnetic Resonance Imaging Surveillance in Children and Adults With Cancer Predisposition Syndromes: A Retrospective Study. JCO Precis Oncol. 2025 Mar;9:e2400642. doi: 10.1200/PO-24-00642. Epub 2025 Mar 26. Erratum in: JCO Precis Oncol. 2025 Apr;9:e2400276. PMID: 40138602 (IF: 5.3)
• Yuen J, Zhou S, Caeser R, Venkatramani M, Bte Ishak DN, Li ST, Zhang Z, Chiang J, Chan SH, Ngeow J^. Multi-locus inherited neoplasia alleles syndromes in cancer: implications for clinical practice. Eur J Hum Genet. 2025 Mar;33(3):289-296. PMID: 39843919 (IF: 3.7)
• Tasnim S, Lim PXH, Griva K, Ngeow J^. Identifying the psychosocial barriers and facilitators associated with the uptake of genetic services for hereditary cancer syndromes: a systematic review of qualitative studies. Health Psychol Rev. 2025 Mar;19(1):172-199. Epub 2024 Oct 22. PMID: 39435867 (IF: 6.6)
• Chiang J, Chua Z, Chan JY, Sule AA, Loke WH, Lum E, Ong MEH, Graves N, Ngeow J^. Strategies to improve implementation of cascade testing in hereditary cancer syndromes: a systematic review. NPJ Genom Med. 2024 Apr 3;9(1):26. PMID: 38570510 (IF: 7.4)
• Ho WK, Hassan NT, Yoon SY, Yang X, Lim JMC, Binte Ishak ND, Ho PJ, Wijaya EA, Ng PP, Luccarini C, Allen J, Tai MC, Chiang J, Zhang Z, See MH, Thong MK, Woo YL, Dunning AM, Hartman M, Yip CH, Mohd Taib NA, Easton DF, Li J, Ngeow J^, Antoniou AC^, Teo SH^. Age-specific breast and ovarian cancer risks associated with germline BRCA1 or BRCA2 pathogenic variants - an Asian study of 572 families. Lancet Reg Health West Pac. 2024 Feb 5;44:101017. PMID: 38333895 (IF: 7.6)
• Li L, Kolinjivadi AM, Ong KH, Young DM, Marini GPL, Chan SH, Chong ST, Chew EL, Lu H, Gole L, Yu W, Ngeow J^. Automatic DNA replication tract measurement to assess replication and repair dynamics at the single-molecule level. Bioinformatics. 2022 Sep 15;38(18):4395-4402. PMID: 35881697 (IF: 5.8)
• Chan SH, Bylstra Y, Teo JX, Kuan JL, Bertin N, Gonzalez-Porta M, Hebrard M, Tirado-Magallanes R, Tan JHJ, Jeyakani J, Li Z, Chai JF, Chong YS, Davila S, Goh LL, Lee ES, Wong E, Wong TY; SG10K_Health Consortium; Prabhakar S, Liu J, Cheng CY, Eisenhaber B, Karnani N, Leong KP, Sim X, Yeo KK, Chambers JC, Tai ES, Tan P, Jamuar SS, Lim WK^. Ngeow J^. Analysis of clinically relevant variants from ancestrally diverse Asian genomes. Nat Commun. 2022 Nov 5;13(1):6694. PMID: 36335097 (IF 16.1)
• Chan SH, Ni Y, Li ST, Teo JX, Ishak NDB, Lim WK, Ngeow J^. Spectrum of Germline Mutations Within Fanconi Anemia-Associated Genes Across Populations of Varying Ancestry. JNCI Cancer Spectr. 2021 Jan 5;5(1):pkaa117. PMID: 35929646 (IF 11.6)
• Chan JY, Toh MR, Chong ST, Ishak NDB, Kolinjivadi AM, Chan SH, Lee E, Boot A, Shao-Tzu L, Chew MH, Ngeow J^. Multiple neoplasia in a patient with Gitelman syndrome harboring germline monoallelic MUTYH mutation. NPJ Genom Med. 2020 Sep 18;5:39. PMID: 33024574 (IF 5.8)
• Hong JH, Chong ST, Lee PH, Tan J, Heng HL, Ishak NDB, Chan SH, Teh BT, Ngeow J^. Functional characterisation guides classification of novel BAP1 germline variants. NPJ Genom Med. 2020 Nov 19;5:50. PMID: 33240524 (IF 5.802)