Dr Sim Jingwei

Dr Sim Jingwei is an Associate Consultant in the Department of Neurology, National Neuroscience Institute. Dr Sim completed her Internal Medicine residency under SingHealth in 2021, followed by Neurology senior residency training in 2025.

Dr Sim holds a doctorate from the University of Cambridge, during which she investigated oxygen sensing pathways in cells, and how these regulate ​metabolism in vivo. She is curious about neurodegenerative disorders, behavioural neurology and medical prognostication. She firmly believes in patient-centred and compassionate care. In addition, she appreciates museums, art and long nature walks.

• Specialty Certificate in Neurology, Royal College of Physicians of the United Kingdom 2022
• MMED (Internal Medicine), National University of Singapore 2021
• MRCP (UK), Royal College of Physicians of the United Kingdom 2021
• MB BChir, University of Cambridge, United Kingdom 2017
• PhD (Physiology), University of Cambridge, United Kingdom 2016

• Associate Consultant, Department of Neurology, National Neuroscience Institute
• Clinical Educator, Lee Kong Chian School of Medicine (NTU)
• Adjunct Research Fellow, SingHealth Duke-NUS Medicine ACP 

NNI Quality Service Award 2025, Gold

Singapore Healthcare Quality Service Award 2025, Silver 

Service with a Heart Award, Singapore General Hospital, 2018

For a full list of Dr Sim's publications, visit: ‪Jingwei Sim‬ - ‪Google Scholar‬

Tan, W.H., Sim, J., Sultana, R., Lee, H.Y. Rituximab in subepidermal blistering diseases. Dermatology 2023; 239(6), 5-11.  

Lu, X., Prodger, A., Sim, J., Evans, C.E. Pulmonary thrombosis promotes tumorigenesis via myeloid hypoxia-inducible factors. Biomolecules 2022; 12(10), 1354-1367. 

Sim, J., Goh, W.Y., Wiryasaputra, L., Hum, A.Y., Neo, H.Y., Poi, C.H. Use of phenobarbitone for palliative sedation in dyspneic crises due to COVID-19 pneumonia. J Pain Palliat Care Pharmacother 2022; 36, 1-7.

Sim, J., Narasimhalu, K., Tan, E-K. A man with an arched back. Parkinsonism Relat Disord 2022; 103, 175-176.

Sim, J., Yong, K.P., Narasimhalu, K. A case of rapidly-progressive insomnia and dysautonomia. Annals Academy of Medicine, Singapore 2022; 51(8):512-513. 

Sim, J., Narasimhalu, K. Electrical myotonia and antibiotic induced myasthenic crises:  A novel CHRNE variant. Neurology Asia 2022; 27(3), 787-789.  

Sim, J., Li, H., Hameed, S., Ting, S.K.S. Clinical manifestations of early-onset dementia with Lewy bodies compared with late-onset dementia with Lewy bodies and early-onset Alzheimer’s disease. JAMA Neurol 2022; 79(7):702-709. 

Sim, J., Wang, Y.T., Mamun, K., Tay, S.Y., Doshi, K., Hameed, S., Ting, S.K.  (2021). Assessment of small intestinal bacterial overgrowth in Alzheimer’s disease. Acta Neurol Taiwan 2021; 30(3), 102-107. 

Sim, J., Cowburn, A.S., Palazon, A., Madhu, B., Tyrakis, P.A., Macias, D.; Bargiela, D.M.; Pietsch, S.; Gralla, M.; Evans, C.E., Kittipassorn, T., Chey Y.C.J.; Branco, C.M., Rundqvist, H., Peet, D.J., Johnson, R.S. (2018). The FIH asparaginyl hydroxylase regulates oxidative metabolism and accelerates metabolic adaptation to hypoxia. Cell Metabolism 27(4), 898-913. 

Tyrakis, P.A., Palazon, A., Macias, D., Lee, K.L., Phan, A.T., Velica, P., You, J., Chia, G.S., Sim, J., Doedens, A., Abelanet, A., Evans, C.E., Griffiths, J.R., Poellinger, L., Goldrath, A.W., Johnson, R.S. (2016). S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate. Nature 540, 236-241. 

Evans, C.E, Palazon, A., Sim, J., Tyrakis, P.A., Prodger, A., Lu, X., Chan, S., Bendahl, P., Belting, M., von Euler, L., Rundqvist, H., Johnson, R.S., Branco, C. (2017). Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis. Biology Open 6, 688-697. 

Sim, J., Johnson, R.S. (2015). Through a clear cell, darkly: HIF2α/PLIN2–maintained fat droplets protect ccRCCs from ER stress. Cancer Disc 5(6), 584-585. 

Sim, J., Johnson, R.S. (2014). A whiter shade of gray: HIF and coordination of angiogenesis with postnatal myelination. Dev Cell 30(2), 116-117. 

Sim, J., Fraser, J.A. (2014). The determinants of transverse tubular volume in resting skeletal muscle. J Physiol 24(592), 5477-92.