Clin Asst Prof Crystal Yeo

Dr Crystal Jing Jing Yeo is a Diplomate of the American Board of Psychiatry and Neurology (Board Certified in Neurology and Neuromuscular Medicine), and American Board of Electrodiagnostic Medicine (Board Certified in Electrodiagnostic Medicine and Neuromuscular Ultrasound). She specialises in the care of patients with Neuromuscular diseases, and in nerve conductions, electromyography (NCS/EMG) and neuromuscular ultrasound.

She graduated from the University of Cambridge MB/PhD programme with Distinction in Medicine, PhD in Immunology and Honours for top performance, including The Lewin Prize, Balfour Prize and Caroline Turle Prize. She completed her Neurology residency at Weil Cornell Medicine/Houston Methodist Hospital, and Neuromuscular fellowship at Harvard University/Massachusetts General Hospital, Brigham and Women’s Hospital and Boston Children’s Hospital. She is Adjunct Associate Professor in Neurology (Neuromuscular Disease) at the Feinberg School of Medicine, Northwestern University, Honorary Senior Lecturer at the School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Newnham Associate at the University of Cambridge, Associate Staff at Boston Children’s Hospital, and directs the Translational Neuromuscular Medicine Laboratory at A*STAR.

Dr Yeo is also alumnus of the American Academy of Neurology (AAN) Palatucci Advocacy Leadership Forum, AAN Live Well Lead Well Leadership Program, Harvard Women in Leadership Course, and serves on the AAN Education Pipeline Subcommittee. She has been invited to give talks and interviews to the American Association of Neuromuscular and Electrodiagnostic Medicine, American Neurological Association, AAN, ACGME, US Women Neurologists Group, and local and international universities. She is involved in lecturing medical and graduate students at the Lee Kong Chian School of Medicine and National University of Singapore.

Her research interests focus on developing integrated translational precision medicine approaches for ALS, SMA, and related neuromuscular disorders, combining longitudinal clinical phenotyping, patient registries, biospecimen resources, multi-omics analyses, artificial intelligence (AI), and patient-derived induced pluripotent stem cell (iPSC) disease models to enable biomarker discovery, disease stratification, and trial readiness. She is involved in developing integrated ALS and SMA translational infrastructure in Singapore, linking clinical care, biological research, and data-driven approaches to support precision medicine. Her work has been recognised through international awards including the American Neuromuscular Foundation and American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) Surinderjit Singh Young Lectureship Award and AANEM Scientific Impact Award.

• FRCP (London), 2026
• American Board of Electrodiagnostic Medicine (Board Certified in Neuromuscular Ultrasound, 2022)
• American Board of Electrodiagnostic Medicine (Board Certified in Electrodiagnostic Medicine), 2020
• American Board of Psychiatry and Neurology (Board Certified in Neuromuscular Medicine), 2020
• Harvard/Partners Neuromuscular Medicine Fellowship at Harvard University, Massachusetts General Hospital, Brigham and Women’s Hospital, Boston Children’s Hospital, 2018-2019
• American Board of Psychiatry and Neurology (Board Certified in Neurology), 2018
• Weill-Cornell Medicine/Houston Methodist Hospital Neurology Residency, 2014-2018
• MRCP (United Kingdom), 2013
• MB BChir (University of Cambridge, Distinction), PhD (University of Cambridge), 2011

• ​Consultant, Department of Neurology, National Neuroscience Institute, 2022 - present
• Editorial Board, Muscle and Nerve, 2026 - present
• Grant Review Committee, American Neuromuscular Foundation, 2026 - present
• Adjunct Associate Professor of Neurology (Neuromuscular Disease), Feinberg School of Medicine, Northwestern University, 2021 - present
• Honorary Senior Lecturer, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, 2020 - present 
• Group leader of Translational Neuromuscular Medicine Laboratory, 2019 - present
• Clinical Assistant Professor, Duke-NUS Medical School​
• ​Clinical Lecturer, NUS Yong Loo Lin School of Medicine
• Clinical Educator, Lee Kong Chian School of Medicine
• Joint Medical Director of the Experimental Drug Development Center, 2019 - 2021

• AANEM Scientific Impact Award, 2026
• American Neuromuscular Foundation and AANEM Surinderjit Singh Young Lectureship Award, 2025
• A*STAR CDA Grant, 2020
• American Academy of Neurology (AAN) Live Well Lead Well Leadership Programme, 2019
• AAN Fellow Scholarship to the AAN Annual Conference, 2019
• AAN Palatucci Advocacy Leadership Forum Action Plan Support Grant, 2018
• Harvard/Partners Healthcare Center of Expertise Health Policy and Management Grant for the Harvard Business School Healthcare Conference, 2018
• AAN Palatucci Advocacy Leadership Forum, 2018
• AAN Brainstorm Competition – Grand Finals, 2018
• Grifols CIDP Ambassador Programme, 2018 
• International Neuroethics Society Essay Competition Editorial Mentorship, 2017
• 9th Annual American Neurological Association Translational and Clinical Research Course Award, 2017
• American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) Resident and Fellowship Abstract Award, 2017
• AANEM Foundation for Research and Education Resident and Fellow Member Recognition Award, 2017
• MDS-PAS Movement Disorders School Award, 2017
• Cleveland Clinic 5th Annual Comprehensive Neurotoxin Course Travel Award, 2016
• Distinction in MB BChir, University of Cambridge, 2011
• The Lewin Prize, University of Cambridge, 2011
• Caroline Turle Prize, University of Cambridge, 2011
• Balfour Prize, University of Cambridge, 2011
• Distinction in Pathology, University of Cambridge, 2010
• PhD in Medicine, University of Cambridge, 2010
• Cow and Gate Prize for Pediatrics, University of Cambridge, 2010
• Commendation for Outstanding Performance in Pediatrics, University of Cambridge, 2010
• Boyd-Martin Award, University of Cambridge, 2010 
• William Harvey Studentship Award in Clinical Medicine, University of Cambridge, 2006
• Robert Lin Memorial Medal for Pharmacology, 2005
• 2nd Professional Exam MBBS Part 2: Dean’s List, 2005
• A*STAR Roll of Honor, 2005
• 2nd Professional Exam MBBS Part 1: Dean’s List, 2004
• First Professional Exam MBBS: Dean’s List, 2003
• Singapore Medical Association Ethics Essay Competition: 1st Prize, 2002
• A*STAR MBBS-PhD Scholarship Award, 2002
• Raffles Junior College Award for Academic Excellence, 2001
• Stanford Book Prize, 2001
• Edusave EAGLES Award for Achievement, Good Leadership and Servic, 2001
• Lee Kuan Yew Award for Excellence in Mathematics and Science, 2001
• Raffles Top Scholar Award for Top GCE O Level 11 Distinctions, 1999      
• RGS Award for Excellence in Chemistry and Music, 1999

• Yeo, Crystal Jing Jing. "The Tuesday lessons of ALS." The Lancet. Neurology 25.3 (2026): 231.
• Nevin Tham, Joanne Ngeow, Crystal Jing Jing Yeo*. Predictive Network-Medicine Modeling Prioritizes Combinatory Drugs for Amyotrophic Lateral Sclerosis, 24 February 2026, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-8762264/v1]
• Sun, L., Leow, D. M. K., Wang, L. C., Eio, M. Y., Koh, H. W., Khong, Z. J., ... & Yeo, C. J. J*. “Liver Steatosis in Induced Hepatocytes From Carriers of Spinal Muscular Atrophy,” Muscle & Nerve73, no. 4 (2026): 675–682
• Yeo CJJ, Ramasamy S, Joel Leong F, Nag S, Simmons Z. A neuromuscular clinician’s primer on machine learning. Journal of Neuromuscular Diseases. 2026;13(1):20-42. doi:10.1177/22143602251329240
• Guo, L., Xu, I. Q., Nag, S., Xu, J., Chai, J., Simmons, Z., ... & Yeo, C. J. J*. (2025). Predicting Amyotrophic Lateral Sclerosis Mortality With Machine Learning in Diverse Patient Databases. Muscle & Nerve, 72(4), 653-661.
• Yeo CJJ, De Vivo DC, Darras BT. Further Comments on Risdiplam for Prenatal Therapy of Spinal Muscular Atrophy. N Engl J Med. 2025 Jul 3;393(1):103-104. doi: 10.1056/NEJMc2504911. PMID: 40601959.
• Xu IQ, Guo L, Xu J, Setiawan S, Deng X, Lo YL, Chai JYH, Simmons Z, Ramasamy S, Yeo CJJ*. Predictive Analysis of Amyotrophic Lateral Sclerosis Progression and Mortality in a Clinic Cohort From Singapore. Muscle Nerve. 2025 Jul;72(1):71-81. doi: 10.1002/mus.28416. Epub 2025 Apr 23. PMID: 40265300; PMCID: PMC12138491.
• Yeo CJJ, Ramasamy S, Joel Leong F, Nag S, Simmons Z. A neuromuscular clinician's primer on machine learning. J Neuromuscul Dis. 2025 Apr 1:22143602251329240. doi: 10.1177/22143602251329240. Epub ahead of print. PMID: 40165764.
• Wu H, Wang LC, Sow BM, Leow D, Zhu J, Gallo KM, Wilsbach K, Gupta R, Ostrow LW, Yeo CJJ, Sobota RM, Li R. TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport. Nat Commun. 2024 Oct 19;15(1):9026. doi: 10.1038/s41467-024-52706-7. PMID: 39424779; PMCID: PMC11489672.
• Yeo CJJ, Simmons Z. Caring for people living with ALS in Korea: challenges and possible paths forward. Muscle Nerve. 2024 Nov;70(5):881-883. doi: 10.1002/mus.28241. Epub 2024 Aug 29. PMID: 39210549.
• Leow DM, Ng YK, Wang LC, Koh HW, Zhao T, Khong ZJ, Tabaglio T, Narayanan G, Giadone RM, Sobota RM, Ng SY, Teo AK, Parson SH, Rubin LL, Ong WY, Darras BT, Yeo CJ*. Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy. J Clin Invest. 2024 May 9:e173702. doi: 10.1172/JCI173702. Epub ahead of print. PMID: 38722695.
• Yeo CJJ, Tizzano EF, Darras BT. Challenges and opportunities in spinal muscular atrophy therapeutics. Lancet Neurol. 2024 Feb;23(2):205-218. doi: 10.1016/S1474-4422(23)00419-2. PMID: 38267192.
  
• Din Abdul Jabbar MA, Guo L, Guo Y, Simmons Z, Pioro EP, Ramasamy S, Yeo CJJ*. Predicting amyotrophic lateral sclerosis (ALS) progression with machine learning, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2023 Dec DOI: 10.1080/21678421.2023.2285443
• Din Abdul Jabbar MA, Guo L, Guo Y, Simmons Z, Pioro EP, Ramasamy S, Yeo CJJ*. Describing and characterising variability in ALS disease progression. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Oct 5:1-12. PMID: 37794802.
• Yeo CJJ, Darras BT. Translating fatigability in spinal muscular atrophy to clinical trials and management. Muscle Nerve. 2023 Jul;68(1):6-7. doi: 10.1002/mus.27831. Epub 2023 Apr 22. PMID: 37086214; PMCID: PMC10334865.
• Yeo CJJ, Dastgir J, Darras BT. Neonatal Hypotonia and Neuromuscular Disorders. Perlman J, Neurology: Neonatology Questions and Controversies, 4e, Chapter 13, 213-236
• Huber RG, Pandey S, Chhangani D, Rincon-Limas DE, Staff NP, Yeo CJJ*. Identification of potential pathways and biomarkers linked to progression in ALS. Ann Clin Transl Neurol. 2022 Dec 19. doi: 10.1002/acn3.51697.
• Ong WY, Leow DM, Herr DR, Yeo CJ. What Do Randomized Controlled Trials Inform Us About Potential Disease- Modifying Strategies for Parkinson's Disease? Neuromolecular Med. 2022 Jul 1. doi: 10.1007/s12017-022-08718-x. PMID: 35776238
  
• Crystal Jing Jing Yeo, Alexis Levine, Basil Darras. Hepatic Steatosis in Patients with Spinal Muscular Atrophy (SMA). Neurology May 2022, 98 (18 Supplement) 2692
• Muzammil Arif Din Abdul Jabbar, Guo Yang, Erik Pioro, Savitha Ramasamy, Crystal Jing Jing Yeo*. Implications and Predictors of Variability of Disease Progression in Amyotrophic Lateral Sclerosis (ALS). Neurology May 2022, 98 (18 Supplement) 1873
• Muzammil Arif Din Abdul Jabbar, Guo Yang, Erik Pioro, Savitha Ramasamy, Crystal Jing Jing Yeo*. Predicting Fast Progressors in Amyotrophic Lateral Sclerosis (ALS): A Machine Learning Approach. Neurology May 2022, 98 (18 Supplement) 1891
• Roland Huber, Crystal Jing Jing Yeo*. Fast Progression in Amyotrophic Lateral Sclerosis: Pathways and Biomarkers from Multi-Omics Analysis. Neurology May 2022, 98 (18 Supplement) 696
• Yeo CJJ, Simmons Z, De Vivo DC, Darras BT. Reply to: The 4-Copy Conundrum in the Treatment of Infants with Spinal Muscular Atrophy. Ann Neurol. 2022 Jun;91(6):892. doi: 10.1002/ana.26357. Epub 2022 Apr 9. PMID: 35332578
• Yeo CJJ, Simmons Z, De Vivo DC, Darras BT. Ethical Perspectives on Treatment Options with Spinal Muscular Atrophy Patients. Ann Neurol. 2022 Mar;91(3):305-316. doi: 10.1002/ana.26299. Epub 2022 Jan 25. PMID: 34981567.
• Yeo CJJ, Darras BT. A tale of two diseases: spinal muscular atrophy and Pompe disease. Lancet Child Adolesc Health. 2022 Jan;6(1):2-3. doi: 10.1016/S2352-4642(21)00351-5. Epub 2021 Nov 22. PMID: 34822770.
• Yeo, C.J.J. and Darras, B.T. Hepatic Steatosis in Patients with Spinal Muscular Atrophy. Ann Neurol. 2021 Oct, Volume 90, Issue S27.
• Yeo CJJ and Darras BT. Overview of Spinal Muscular Atrophy for the Child Neurology Foundation. June 2021
• Yeo, C.J.J. and Darras, B.T. (2020), Yeo and Darras: Extraneuronal Phenotypes of Spinal Muscular Atrophy. Ann Neurol. 2020 Oct 13. doi: 10.1002/ana.25930. https://doi.org/10.1002/ana.25930
• Angkodjojo S, Yeo CJJ. A Patient with Limbic Encephalitis, Ear Perichondritis, and Episcleritis – An Unusual Presentation of Relapsing Polychondritis. Case Rep Neurol 2020;12:378-386. doi: 10.1159/000510634
• Yeo CJJ, Simeone SD, Townsend EL, Zhang RZ, Swoboda KJ. Prospective Cohort Study of Nusinersen Treatment in Adults with Spinal Muscular Atrophy. J Neuromuscul Dis. 2020;7(3):257-268. doi: 10.3233/JND-190453.
• Yeo CJJ, Darras BT. Overturning the Paradigm of Spinal Muscular Atrophy as just a Motor Neuron Disease. Pediatr Neurol. 2020;S0887-8994(20)30027-8. doi:10.1016/j.pediatrneurol.2020.01.003
• Yeo CJ, Schwarz H, O’Donovan C, Busis N, Deb A, Wiesman J, Powell S, Molano J. Providing an easily accessible online resource for physician wellness advocates (2358). Neurology Apr 2020, 94 (15 Supplement) 2358
• Yeo CJ, Ng SY, Darras BT. Reduced Spinal Motor Neuron Expression of Insulin-like Growth Factor-2 and Insulinlike Growth Factor Binding Protein 5 in Spinal Muscular Atrophy Type 1 (1262). Neurology Apr 2020, 94 (15 Supplement) 1262
• Yeo CJ, Simeone S, Zhang RZ, Trautman K, Damron B, Nwe P, Siranosian J, Johnstone A, Chen JY, Townsend E, Nery F, Herrmann M, Swoboda K. Outcome measures for Nusinersen efficacy in Adults with Spinal Muscular Atrophy. Neurology Apr 2019, 92 (15 Supplement) S5.008
• Yeo CJ, Babieri A, Roman G, Wiesman J, Powell SZ. Using Smartphone Mindfulness Apps to Increase Trainee Resilience and Reduce Burnout. Neurology Apr 2019, 92 (15 Supplement) P2.9-005
• Yeo CJ et al. Scrubber’s Radial Palsy - Proximal Compression of the Radial Nerve at the Origin of the Brachioradialis. Neurology Apr 2019, 92 (15 Supplement) P4.4-037
• Yeo CJJ. Haiku on Phone. Closler, Johns Hopkins Medicine June 2019
• Yeo CJJ. Bringing compassion, resiliency and humanity to medicine. Brigham and Women’s Hospital Clinical and Research News Jan 2019
• Yeo CJJ, Román GC, Kusnerik D, Burt T, Mersinger D, Thomas S, Boone T, Powell SZ. Trainee Responses to Hurricane Harvey: Correlating Volunteerism With Burnout. Front Public Health. 2018; 6:224.
• Yeo CJJ. Right Brain: Should we wear flowers in our hair? Neurology Oct 2018, 91 (16) 761; DOI: 10.1212/WNL.0000000000006364
• Yeo CJJ. Neurology, May 16, 2018 e-Pearl of the Week: Antiphospholipid antibody-associated chorea. http://n.neurology.org/epearls/20180516
• Yeo CJJ, Hutton GJ, Fung SH. Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year. Radiol Case Rep. 2018 Oct; 13(5):1030-1035.
• Yeo CJ, Ondo W. Tremor Research Group Essential Tremor Rating Scale (TETRAS): Assessing Impact of Different Item Instructions. Neurology Apr 2018, 90 (15 Supplement) P6.062
• Yeo CJJ and Pleitez M. Eculizumab in Refractory Myasthenia Crisis. Muscle Nerve. 2018 Aug; 58(2):E13-E15.
• Yeo CJJ and Simmons Z. Discussing edaravone with the ALS patient: an ethical framework from a U.S. perspective, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2018, 19:3-4, 167-172
• Yeo CJJ, Britz G, Powell, S, Smith, R & Zhang, Yi. Recurrent Cerebral Hemorrhages in Normal Pregnancy Secondary to Mycotic Pseudoaneurysms Related to Choriocarcinoma. World Neurosurg. 2018 Jan; 109:247- 250.
• Yeo CJ, Bunin V, Popovich J, Cykowski M, Smith R. Mitochondrial Skeletal and Cardiac Myopathy Responsive to Aggressive Immunosuppression in Rapidly Progressing Systemic Sclerosis. Neurology Apr 2017, 88 (16 Supplement) P5.077
• Yeo CJ, McCane D, Katz L, Ling K, Capetillo A, Bledsoe D, Chiu D. Variables affecting stroke outcome for t-PA received between 3 to 4.5 hours. Neurology Apr 2016, 86 (16 Supplement) P2.301
• Yeo CJ, Gilman AL. Interleukin-2-induced graft-versus-leukemia for the treatment of AML in a BRCA2 Fanconi anemia patient. Journal of Pediatric Hematology/oncology. 2014 Mar;36(2):e78-80.
• Yeo CJJ, Fearon DT. T-bet-mediated differentiation of the activated CD8+ T cell. European Journal of Immunology. 2011 Jan; 41(1):60-66.
• Yeo CJJ. Ethical dilemmas of the practice of medicine in the information technology age. Singapore Med J 2003; 44:141-4.

*Senior Corresponding Author