Dr Francesca Lorraine Lim

MBBS, BSc, MMed(Int Med), MRCP(UK)

Senior Consultant

Singapore General Hospital

Specialty: Haematology

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About

Education and Training

Professional Appointments and Committee Memberships

Publications

Conditions Treated By This Doctor

Acute Lymphocytic Leukemia (ALL) Acute Myelogenous Leukemia (AML) Chronic Lymphocytic Leukemia (CLL) Lymphoma Multiple Myeloma Myelodysplastic Syndromes Myelofibrosis

Clinical Interests

Haematopoietic Stem Cell ＆ Cellular Therapy

Clinical Appointments

Senior Consultant

SingHealth Duke-NUS Blood Cancer Centre

Senior Consultant

SingHealth Duke-NUS Transplant Centre

Senior Consultant

Haematology

Senior Consultant

Academic Appointments

Assistant Professor

About

Dr Lim is a Senior Consultant Hematologist at Singapore General Hospital, Chief Medical Officer (CMO) at the Advanced Cell Therapy and Research Institute Singapore (ACTRIS), and Deputy Head of the Singhealth Duke-NUS Cell Therapy Center.

Dr Lim spent 2 years training at MD Anderson Cancer Center on CAR T cell therapy particularly on CAR NK cell therapy under Professor Katy Rezvani as well as in the Good Manufacturing Processing Facility (GMP). Since her return from MD Anderson Cancer Center, Dr Lim has been instrumental in supporting and coordinating the Cell Therapy Program at SGH Haematology, SingHealth, both at the clinical, research and translational level.

Education and Training

MBBS, BSc (UK), UCL& RFC
MMed(Int Med), MRCP(UK), Royal College of Medicine

Professional Appointments and Committee Memberships

Assistant Professor, Duke-NUS Medical School
Chief Medical Officer (CMO), Advanced Cell Therapy and Research Institute Singapore (ACTRIS), Deputy
Head, Singhealth Duke NUS Cell Therapy Center
Member, Singapore Society of Haematology

Publications

Proven and unproven cell therapies – what we have learned so far? Francesca.L.W.I.Lim. ISBT Science Series. April 2021; doi: 10.1111/voxs.12636
Cost-effectiveness and budget impact analyses of tisagenlecleucel in adult patients with relapsed or refractory diffuse large B cell lymphoma from Singapore’s private insurance payer’s perspective. Wang XJ, Wang YH, Li SCT, Gkitzia C, Lim ST, Koh LP, Lim FLWI, Hwang WYK.J Med Econ. 2021 Apr 27:1. doi: 10.1080/13696998.2021.1922066.
Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells.
May Daher, Rafet Basar,…,Francesca Lorraine Wei Inng Lim…Katayoun Rezvani. Blood, The Journal of the American Society of Hematology 137 (5), 624-636, 2021.
Metabolic reprograming of GMP grade cord tissue derived mesenchymal stem cells enhances their suppressive potential in GVHD. Mayela Mendt, May Daher, Rafet Basar, Mayra Shanley…Francesca Lim Wei Inng… Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani. Frontiers in Immunology. (631353) 2021
AFM13-Targeted Blood and CORD-blood-derived memory-like NK cells as therapy for CD30+ malignancies. Lucial Kerbauy, Nancy Marin, Mecit Kaplan...Francesca Wei Inng Lim,…Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani. J ImmunotherCancer. Dec 2020; 8 (suppl 3): A1-A559.
CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor. May Daher, Rafert Basar, Elif Gokdemir,…Francesca Lorraine Wei Inng Lim….Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani. bioRxiv. March 2020.
Emerging CAR landscape for cancer immunotherapy. FLWI Lim, SO Ang. Biochemical Pharmacology. August 2020, 114051.
Donor-type fresh frozen plasma is effective in preventing hemolytic reaction in major ABO incompatible allogeneic stem cell transplant. Quek J, Lee JJ, Lim FL, Diong C, Goh YT, Gopalakrishnan S, Ho A, Hwang W, Koh M, Loh Y, Linn YC. Transfusion. Jan 2019; 59 (1): 335-339
Mobilization kinetics of peripheral blood stem cells with rescue plerixafor – a real-world experience from a single center. Khaing Shwe Wah Pwint, Yunxin Chen, Colin Phipps Diong, Yeow-Tee Goh, Dixon Grant, Aloysius Ho, William Hwang, Sathish Kumar, Yuh-Shan Lee, Francesca Lim, Yvonne Loh, Chandramouli Nagarajan, Jeffrey Quek, Miriam Tao, Hein Than and Yeh-Ching Linn. Leukemia & Lymphoma. Feb 2020. DOI: 10.1080/10428194.2020.1731501
Low-dose insulin-like growth factor binding proteins 1 and 2 and angiopoietin-like protein 3 coordinatesly stimulate ex vivo expanaion of human umbilical cord blood hematopoietic stem cells as assayed in NOD/SCID gamma null mice. Fan X, Florence PH Gay, Francesca WI Lim….William YK Hwang. Stem Cell Res Ther. 2014.5(3): 71.
Cutaneous follicular hyperkeratotic spicules–the first clinical sign of multiple myeloma progression or relapse. LK Tay, FL Lim, HJ Ng, HY Lee, SM Pang, T Thirumoorthy. International journal of dermatology 2010. 49 (8), 934-936
Respiratory virus infection after allogeneic hematopoietic stem cell transplant in a tropical center: predictive value of the immunodeficiency scoring index. L Wang, J Allen, C Diong, YT Goh, S Gopalakrishnan, A Ho, W Hwang. Transplant Infectious Disease 19 (3), e12693
An exploration of the applicability of the refined disease risk index and its integration with other independent risk factors for individualized prognostication VV Maka, LP Koh, C Diong, YT Goh, S Gopalakrishnan, A Ho, W Hwang, Bone marrow transplantation 52 (3), 363-371
Use of defibrotide to treat transplant-associated thrombotic microangiopathy: a retrospective study of the Paediatric Diseases and Inborn Errors Working Parties of the European. L Yeates, MA Slatter, S Bonanomi, FLWI Lim, SY Ong, A Dalissier, Bone marrow transplantation 52 (5), 762-764
Exploring the Cord Blood T Cell Compartment with Mass Cytometry Reveals the Existence of Memory CD4, CD8 and Regulatory T Cell Pools in the Fetal Period. M Muftuoglu, L Li, J Jimenez, D Mak, JK Burks, B Hu, FLWI Lim, H Shaim, Blood 130 (Supplement 1), 4467-4467
Usefulness of an Immunodeficiency Scoring Index for predicting outcomes of respiratory virus infections in allogeneic stem cell transplant recipients: P525. L Wang, J Allen, C Diong, YT Goh, S Gopalakrishnan, FLWI Lim, A Ho, W Hwang,Bone Marrow Transplantation 51
Re-Engraftment of Prior Cord Blood Graft in a Patient with Relapsed/Refractory Acute My-eloid Leukaemia following Haploidentical Transplantation F Lim, S Bari, WYK Hwang. Int J Stem Cell Res Transplant 3 (6), 125-128
Evaluation of Revised Vaccination Guideline for Hematopoietic Cell Transplant Patients in Singapore General Hospital. YJ Lim, HY Ng, MF Chong, YLC Lim, YC Linn, Y Loh, YT Goh,, …, FWI Lim. Biology of Blood and Marrow Transplantation 20 (2), S292-S293
Evaluation of Human Polyomavirus (BKV)–Specific T Cell Immune Reconstitution in Allogeneic Haematopoietic Stem Cell Transplant Recipients. FLWI Lim, AL Teo, YSM Loh, WYK Hwang, YT Goh, KL Ling, YC Linn. Blood, The Journal of the American Society of Hematology 118 (21), 3223-3223
Defibrotide therapy in transplant-associated thrombotic microangiopathy is associated with improved overall survival compared to therapeutic plasma exchange: P955. F Lim, H Ng, W Hwang, Y Linn, Y Goh, C Diong, Y Lee… - Bone Marrow Transplantation, 2011
Hepatic iron concentration, fibrosis and response to venesection associated with the A77D and V162del “loss of function” mutations in ferroportin disease. FL Lim, JS Dooley, AW Roques, L Grellier. 2008. Blood Cell, Molecules.
Cutaneous follicular hyperkeratotic spicules-the first clinical sign of multiple myeloma progression or relapse. LK Tay, FL Lim, HJ Ng, HY Lee. International Journal of Dermatology 2010.