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Asst Prof Teo Wan-Yee

Asst Prof Teo Wan-Yee


Clinician Scientist

National Cancer Centre Singapore

Specialty: Neuro-Oncology

Sub-specialties: Neuro-Oncology

Conditions Treated by this Doctor:
Brain Tumours.

Clinical Appointments

  • Clinician-Scientist, Division of Medicine KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Head, and Principal Investigator, Pediatric Brain Tumor Research Office SingHealth Duke-NUS Academic Medical Centre

Academic Appointments

  • Assistant Professor, Cancer and Stem Cell Biology Program
  • Assistant Professor, Office of Education
  • Assistant Professor SingHealth Duke-NUS Paediatrics Academic Clinical Programme


​Dr Wan-Yee Teo, a clinician-scientist, is the Head and Principal Investigator of the Paediatric Brain Tumor Research Office at SingHealth Duke-NUS Academic Medical Centre, Singapore. She completed her clinical training in Paediatrics and Paediatric NeuroOncology in the USA, and is board certified with the American Board of Paediatrics, and the Royal College of Paediatrics and Child Health in the UK. Her research training was completed in the Cancer Genomics Program at Baylor College of Medicine, USA. Her research combines genomic methodologies and mouse models to study the complex regulation in the developmental biology of brain tumors.

Dr Teo’s laboratory is based at the Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore. The research focuses on the brain tumor microenvironment, particularly in paediatric brain tumors, and translating research findings in tumor biology and genomics to bedside benefits for children with brain tumors. An area of emphasis is the preclinical development of therapeutics for brain tumors using patient-derived brain tumor xenograft modelling. Dr Teo established a competitive laboratory and the Paediatric Brain Tumor Research Office (PBTRO) at SingHealth Duke-NUS Academic Medical Centre, Singapore, in May 2015. She was awarded the SingHealth @IMCB Program Grant to expand two programs in her laboratory (1) Cell Cycle Therapeutic Development Program for Human Cancers, and (2) Artificial Intelligence Laboratory for Human Cancer Translation.


  • American Board of Paediatrics Board Certification
  • PhD, Nanyang Technological University of Singapore (School of Biological Sciences), Singapore
  • Residency, Paediatrics, Inova Children’s Hospital, Virginia Commonwealth University, USA
  • Fellowship, Paediatric NeuroOncology, Baylor College of Medicine, Texas Children’s Hospital, USA
  • Postdoctoral Research Fellowship, Texas Children’s Hematology & Cancer Centers, USA
  • MRCPCH, Royal College of Paediatrics & Child Health, UK
  • MBBS, School of Medicine, National University of Singapore, Singapore

Professional Appointments and Committee Memberships

  • ​Elected Council, College of Clinician Scientists, Academy of Medicine, Singapore
  • Duke-NUS Medical School Research and Scholarship Committee, Singapore
  • Member, Duke-NUS Medical School Clinical Curriculum Review Committee, Singapore
  • Fellow of Royal College of Physicians of Edinburgh
  • Fellow of American Academy of Paediatrics
  • Fellow of American Academy of Paediatrics, Section of Hematology/Oncology
  • Member of Royal College of Paediatrics and Child Health (UK)


  • Ministry of Health-National Medical Research Council (Singapore) Clinician-Scientist Award
  • Ministry of Health-National Medical Research Council (Singapore) Transition Award
  • Richard Schwartz, MD Teaching Award for Excellence, USA
  • Hoshino Award for Young Investigator at 3rd World Federation of Neuro-Oncology by Society for Neuro-Oncology (US), European Association of Neuro-Oncology (EANO) & Asian Society for Neuro-Oncology (ASNO)
  • Travel Fellowship Award for Outstanding Abstract by Asian Society for Paediatric Research at 4th Congress of ASPR at Paediatric Academic Societies' & Asian Society for Paediatric Research Joint Annual Meeting 
  • Ministry of Health-National Medical Research Council (Singapore) Research Training Fellowship Award 
  • Finalist for Young Investigator Award, 43rd Singapore-Malaysia Congress 
  • 2nd Runner-up ENT Bookprize Competition (Faculty of Medicine, National University of Singapore, Singapore Society of Otorhinolaryngology)  

Research Interests


Selected Peer-reviewed Publications

  • Teo WY, Choong CT. Neurological presentations of conversion disorders in a group of Singapore children. Paediatr International. 2008;50(4):533-6.*
  • Teo WY, Chan MY, Ng KC, Tan AM. Bony presentations of childhood hematological malignancies in the emergency room. J Paediatr Child Health. 2012;48(4):311-316.*
  • Teo WY, Chintagumpala M, Okcu MF, Dauser RC, Mahajan A, Adesina AM, Whitehead WE, Jea A, Bollo R, Paulino AC. A retrospective analysis of the patterns of failure in paediatric myxopapillary ependymoma. J Radiat Oncol. 2013;2(1):21-26.*
  • Teo WY, JMF Su, Shen JS, Yu A, Wang J, Chow WY, Li XN, Dauser R, Whitehead W, Adesina AM, Chintagumpala M, Man TZ, Lau CC. Implications of tumor locations on subtypes of medulloblastoma (Priority Report with Commentary Highlight). Ped Blood and Cancer. 2013;60(9):1408-10.
  • Teo WY, Myseros JM. The gut or the brain? –Gastrointestinal Misdiagnoses of Infantile Brain Tumors. Childs Nerv Syst.  2014;30(8):1449-53.*
  • Teo WY, Ross J, Bollo RJ, Seow WT, Tan AM, Kang SG, Kim DS, Mohila CA, Li XN, Lau CC, Adesina AM, Su JMF. Atypical location and clinical behavior of non-teratomatous intracranial germ cell tumors in children. Journal of Neurosurgery-Paediatrics. 2014;25:1-8.* (Podcast Highlight by journal)
  • Teo WY, Kim S, Mensah-Bonsu N. The Curious Case of Ileocolic Intussusception. J Paediatr Child Health. 2014;50(7):573-4.*
  • Teo WY, Dulman RY, Vinh T. Lung Opacification. JAMA. 2014;311(23):2434-5.*
  • Teo WY, Elghetany MT, Shen J, Man TK, Li XN, Chintagumpala M, Su JMF, Dauser R, Whitehead W, Adesina AM, Lau CC. Therapeutic implications of CD1d expression and tumor-infiltrating macrophages in paediatric medulloblastomas. Journal of NeuroOncology. 2014;120(2):293-301.*
  • Lindsay H, Huang Y, Du Y, Braun FK, Teo WY, Kogiso M, Qi L, Zhang H, Zhao S, Mao H, Lin F, Baxter P, Su JM, Terashima K, Perlaky L, Chintagumpala M, Adesina A, Lau CC, Parsons DW, Li XN. Preservation of KIT genotype in a novel pair of patient derived orthotopic xenograft mouse models of metastatic paediatric CNS germinoma. Journal of NeuroOncology. 2016;128(1):47-56.
  • Teo WY, Sekar K, Seshachalam P, Shen J, Chow WY, Lau CC, Yang H, Park J, Kang SG, Li X, Nam DH, Hui KM. Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations. Sci Rep. 2019 May 15;9(1):7442.* Top 100 Most Downloaded Cancer Articles in Scientific Reports in 2019.
  • Teo WY, Sriram B, Alim AA, Ruan X, Rajadurai VS. A single-center observational study on congenital diaphragmatic hernia: Outcome, predictors of mortality and experience from a tertiary perinatal center in Singapore. Pediatr Neonatol. 2020 Mar 13:S1875-9572(20)30042-5.*
  • Teo WY. Implications for Border Containment Strategies when COVID-19 Presents Atypically. Public Health (Official Journal of Royal Society of Public Health, UK). 2020 July 13 (in press).
    DOI: 10.1016/j.puhe.2020.07.019.*
  • Yoon SJ, Son HY, Shim JK, Moon JH, Kim EH, Chang JH, Teo WY, Kim SH, Park SW, Huh YM, Kang SG. Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres. J Transl Med. 2020 Dec 14;18(1):482. doi: 10.1186/s12967-020-02647-8.
* Corresponding Author


Research Trials