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Dr Kandiah Nagaendran from National Neuroscience Institute

Assoc Prof Kandiah Nagaendran

MBBS, FRCP (Edinburgh), FAMS (Neurology)

Senior Consultant

National Neuroscience Institute

Specialty: Neurology

Sub-specialties: Cognitive Neurology

Conditions Treated by this Doctor:
Alzheimer’s Disease, Cognitive Disorders, Mild Cognitive Impairment, Vascular Dementia.

Clinical Appointments

  • Senior Consultant Department of Neurology National Neuroscience InstituteNational Neuroscience Institute

Profile

​Associate Professor Nagaendran Kandiah is a Senior Consultant neurologist and the Director of the NNI Dementia Programme. He holds a Clinician Scientist position with the National Medical Research Council of Singapore. His research interest includes Mild Cognitive Impairment, Role of Cerebrovascular disease in Alzheimer’s dementia, Parkinson’s disease dementia and Frontotemporal Dementia. He holds several national grants investigating these research areas and has published extensively in this field. He is also actively involved in the training aspects of dementia and is currently the chairman of the Neurocognitive and Research Training Consortium of Southeast Asia (NRTC-SEA). From a clinical perspective he has vast experience in the diagnosis and management of Alzheimer’s disease, Vascular dementia, Frontotemporal Dementia, Autoimmune Dementia and other related dementias.  He leads the Singapore Ministry of Health initiative on Comprehensive Young Onset Dementia Programme. He is also the chairman of the Ministry of Health Clinical Practice Guidelines on Dementia.

Education

FRCP (Edinburgh), 2014

FAMS (Singapore), 2007

MBBS, Manipal Academy, 1998

Professional Appointments and Committee Memberships

  • ​Senior Consultant, Department of Neurology, National Neuroscience Institute
  • Associate Professor, Duke – NUS Medical School, Singapore
  • Clinician Scientist, National Medical Research Council, Singapore
  • Clinical Lecturer, Yong Loo Lin Medical School, National University of Singapore
  • Chairman, Chapter of Neurology, Academy of Medicine
  • Director, National Neuroscience Institute Dementia Programme
  • Assistant Director, Clinical Research, National Neuroscience Institute
  • Chairman, Clinical Practice Guidelines for Dementia 2013-2017, Ministry of Health, Singapore
  • Chairman, Neurocognitive and Research Training Consortium, Southeast Asia (NRTC-SEA)
  • Board Member, Asian Society Against Dementia
  • Director of Education, Vas-Cog Society, Asia
  • Panel Member, Open Fund-Young Individual Research Grant, National Medical Research Council
  • Panel Member, Academic Clinical Programme (ACP) Research Support Programme

Awards

  • ​SingHealth Publish Award (Neurology), 2014
  • SingHealth Academy Golden Apple Awards for Program Innovation Award, 2011

Publications and Research Trials

  • Development and validation of a risk score (CHANGE) for cognitive impairment after ischemic stroke. Chander RJ, Lam BYK, Lin X, Ng AYT, Wong APL, Mok VCT, Kandiah N. Sci Rep. 2017 Sep 29;7(1):12441.
  • Atrial Fibrillation is Independently Associated with Cognitive Impairment after Ischemic Stroke. Chander RJ, Lim L, Handa S, Hiu S, Choong A, Lin X, Singh R, Oh D, Kandiah N. J Alzheimers Dis. 2017;60(3):867-875
  • Depressive symptoms influence global cognitive impairment indirectly by reducing memory and executive function in patients with mild cognitive impairment. Yatawara C, Lim L, Chander R, Zhou J, Kandiah N. J Neurol Neurosurg Psychiatry. 2016 Dec;87(12):1375-1383
  • Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedet AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P, Gauthier S; Alzheimer's Disease Neuroimaging Initiative.Neurology. 2017 May 9;88(19):1814-1821.
  • Interaction between APOE-ɛ4 and HMGB1 is associated with widespread cortical thinning in mild cognitive impairment. Foo H, Ng KP, Lim L, Tan YJ, Kandiah N.  JNNP. 2017, June 28
  • Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia.Ting SKS, Foo H, Chia PS, Hameed S, Ng KP, Ng A, Kandiah N. J Neuropsychiatry Clin Neurosci. 2017 Oct 24
  • Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien J, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I; VICCCS group, Ben-Shlomo Y, Passmore AP, Love S, Kehoe PG. Alzheimers Dement. 2017 Oct 19.
  • Experience with a Community-based Multidisciplinary Memory Clinic: A Primary Care Perspective. Wang SZ, Tan GC, Wang XF, De Roza JG, Lim LL, Kandiah N. Ann Acad Med Singapore. 2017 Aug;46(8):321-323
  • Beyond symptomatic effects: Donepezil's potential for neuroprotection and disease modification in Alzheimer's disease. Kim SH, Kandiah N, Hsu JL, Suthisisang C, Udommongkol C, Dash A. Br J Pharmacol. 2017 Sep 13.
  • Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment. Tan YJ, Ng ASL, Vipin A, Lim JKW, Chander RJ, Ji F, Qiu Y, Ting SKS, Hameed S, Lee TS, Zeng L, Kandiah N, Zhou J. J Alzheimers Dis. 2017;58(2):413-423
  • Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images. Guo S, Lai C, Wu C, Cen G; Alzheimer's Disease Neuroimaging Initiative. Front Aging Neurosci. 2017 May 18;9:146.
  • Influence of diabetes mellitus on longitudinal atrophy and cognition in Parkinson's disease. Ong M, Foo H, Chander RJ, Wen MC, Au WL, Sitoh YY, Tan L, Kandiah N. J Neurol Sci. 2017 Jun 15;377:122-126.
  • Foo H, Mak E, Chander RJ, Ng A, Au WL, Sitoh YY, Tan LC, Kandiah N. Associations of hippocampal subfields in the progression of cognitive decline related to Parkinson's disease. Neuroimage Clin. 2016 Dec 12;14:37-42.
  • Yatawara C, Hiu S, Tan L, Kandiah N. Neuropsychiatric symptoms in South-East Asian patients with mild cognitive impairment and dementia: prevalence, subtypes, and risk factors. Int J Geriatr Psychiatry. 2017 Feb 27.
  • Kandiah N, Pai MC, Senanarong V, Looi I, Ampil E, Park KW, Karanam AK, Christopher S. Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson's disease dementia. Clin Interv Aging. 2017 Apr 18;12:697-707
  • Foo H, Mak E, Yong TT, Wen MC, Chander RJ, Au WL, Tan L, Kandiah N. Progression of small vessel disease correlates with cortical thinning in Parkinson's disease. Parkinsonism Relat Disord. 2016 Oct;31:34-40
  • Foo H, Mak E, Yong TT, Wen MC, Chander RJ, Au WL, Sitoh YY, Tan LC, Kandiah N. Progression of subcortical atrophy in mild Parkinson's disease and its impact on cognition Eur J Neurol. 2017 Feb;24(2):341-348.
  • Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedet AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P, Gauthier S; Alzheimer's Disease Neuroimaging Initiative. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017 Apr 12.
  • Wee N, Wen MC, Kandiah N, Chander RJ, Ng A, Au WL, Tan LC. Neural correlates of anxiety symptoms in mild Parkinson's disease: A prospective longitudinal voxel-based morphometry study. J Neurol Sci. 2016 Dec 15;371:131-136
  • Qiu L, Ng G, Tan EK, Liao P, Kandiah N, Zeng L. Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimer's disease mice. Sci Rep. 2016 Apr 6;6:23964.
  • Zainal NH, Silva E, Lim LL, Kandiah N. Psychometric Properties of Alzheimer's Disease Assessment Scale-Cognitive Subscale for Mild Cognitive Impairment and Mild Alzheimer's Disease Patients in an Asian Context.Ann Acad Med Singapore. 2016 Jul;45(7):273-83.
  • Chen C, Homma A, Mok VC, Krishnamoorthy E, Alladi S, Meguro K, Abe K, Dominguez J, Marasigan S, Kandiah N, Kim SY, Lee DY, De Silva HA, Yang YH, Pai MC, Senanarong V, Dash A. Alzheimer's disease with cerebrovascular disease: current status in the Asia-Pacific region.J Intern Med. 2016 Oct;280(4):359-74
  • Sachdev PS, Lo JW, Crawford JD, Mellon L, Hickey A, Williams D, Bordet R, Mendyk AM, Gelé P, Deplanque D, Bae HJ, Lim JS, Brodtmann A, Werden E, Cumming T, Köhler S, Verhey FR, Dong YH, Tan HH, Chen C, Xin X, Kalaria RN, Allan LM, Akinyemi RO, Ogunniyi A, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee BC, Yu KH, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VC, Wong A, Lam BY, Leys D, Hénon H, Bombois S, Lipnicki DM, Kochan NA; STROKOG. STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimers Dement (Amst). 2016 Nov 18;7:11-23.
  • Skrobot OA, O'Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I; VICCCS group., Ben-Shlomo Y, Passmore AP, Love S, Kehoe PG. The Vascular Impairment of Cognition Classification Consensus Study. Alzheimers Dement. 2016 Dec 10. pii: S1552-5260(16)33073-
  • Sabbagh M, Han S, Kim S, Na HR, Lee JH, Kandiah N, Phanthumchinda K, Suthisisang C, Senanarong V, Pai MC, Narilastri D, Sowani AM, Ampil E, Dash A. Clinical Recommendations for the Use of Donepezil 23 mg in Moderate-to-Severe Alzheimer's Disease in the Asia-Pacific Region. Dement Geriatr Cogn Dis Extra. 2016 Sep 9;6(3):382-395
  • Kandiah N, Zhang Angeline; Bautista Dianne Carol; Silva Eveline; Ting Simon Kang Seng; Ng Adeline; Assam Pryseley. Early detection of dementia in multilingual populations: Visual Cognitive Assessment Test (VCAT). J Neurol Neurosurg Psychiatry. 2016 Feb;87(2):156-60
  • Kandiah N, Chander RJ, Lin X, Ng A, Poh YY, Cheong CY, Cenina AR, Assam PN. Cognitive Impairment after Mild Stroke: Development and Validation of the SIGNAL2 Risk Score. J Alzheimers Dis. 2015 Nov 22;49(4):1169-77
  • Ng PS, Ang LP, Kandiah N. Importance of mental capacity: time for greater attention and action. Singapore Med J. 2015 Dec; 56(12):646-8
  • Wee N, Kandiah N, Acharyya S, Chander RJ, Ng A, Au WL, Tan LC. Depression and anxiety are co-morbid but dissociable in mild Parkinson's disease: A prospective longitudinal study of patterns and predictors. Parkinsonism Relat Disord. 2016 Feb;23:50-6.
  • Cenina Alvin R F; De Leon Jasmyn; Tay Kay Yaw; Wong Chin Fong; Kandiah N. Cerebral Amyloid Angiopathy-related Inflammation Presenting With Rapidly Progressive Dementia, Responsive to IVIg. Alzheimer Dis Assoc Disord. 2015 Oct-Dec;29(4):347-9
  • Wen MC, Ng A, Chander RJ, Au WL, Tan LC, Kandiah N. Longitudinal brain volumetric changes and their predictive effects on cognition among cognitively asymptomatic patients with Parkinson's disease. Parkinsonism Relat Disord. 2015 May;21(5):483-8.
  • Wee N, Kandiah N, Acharyya S, Chander RJ, Ng A, Au WL, Tan LC. Baseline predictors of worsening apathy in Parkinson's disease: A prospective longitudinal study. Parkinsonism Relat Disord. 2016 Feb;23:95-8
  • Pai MC, Aref H, Bassil N, Kandiah N, Lee JH, Srinivasan AV, diTommaso S, Yuksel O. Real-world evaluation of compliance and preference in Alzheimer's disease treatment. Clin Interv Aging. 2015 Nov 3;10:1779-88.
  • Mak E, Dwyer MG, Ramasamy DP, Au WL, Tan LC, Zivadinov R, Kandiah N. White Matter Hyperintensities and Mild Cognitive Impairment in Parkinson's Disease. J Neuroimaging. 2015 Sep-Oct;25(5):754-60
  • Ng A, Chander RJ, Tan LC, Kandiah N. Influence of depression in mild Parkinson's disease on longitudinal motor and cognitive function. Parkinsonism Relat Disord. 2015 Sep;21(9):1056-60
  • Chao YX, Ng EY, Li H, Nagaendran K, Yih Y, Chong MS, Prakash KM, Tan L, Au WL, Zhao Y, Zhou ZD, Tio M, Pavanni R, Tan EK. Association Analysis of COQ2 Variant in Dementia and Essential Tremor. Parkinsons Dis. 2015;2015:926280.
  • KANDIAH, Nagaendran; WANG, Vivian; LIN, Xuling; NYU, Mei Mei; LIM, Linda; NG, Adeline; HAMEED, Shahul; WEE, Hwee Lin. Cost Related to Dementia in the Young and the impact of etiological subtype on cost. J Alzheimers Dis. 2015 Sep 29;49(2):277-85.
  • Kandiah N, Zainal NH, Narasimhalu K, Chander RJ, Ng A, Mak E, Au WL, Sitoh YY, Nadkarni N, Tan LC. Hippocampal Volume and White Matter disease in the Prediction of dementia in Parkinson’s disease. Parkinsonism Relat Disord. 2014 Sep 16.
  • Kandiah N, Chander RJ, Ng A, Wen MC, Cenina AR, Assam PN. Association between white matter hyperintensity and medial temporal atrophy at various stages of Alzheimer's disease. Eur J Neurol. 2014 Aug 21.
  • Kandiah N, Zhang A, Cenina AR, Au WL, Nadkarni N, Tan LC. Montreal Cognitive Assessment for the screening and prediction of cognitive decline in early Parkinson's disease. Parkinsonism Relat Disord. 2014 Aug 14. pii: S1353-8020
  • Ng A, Jion YI, Zainal NH, Kandiah N. Renal dysfunction contributes to episodic memory deficits and medial temporal atrophy in Alzheimer's disease: a pilot study. J Am Geriatr Soc. 2014 Oct;62(10):1981-2
  • Kandiah N, Chander R, Zhang A, Yee CC. Cerebral white matter disease is independently associated with BPSD in Alzheimer's disease. J Neurol Sci. 2014 Feb 15;337(1-2):162-6.
  • HO, Vanda, ZAINAL, Nur Hani, LIM, Linda, NG, Aloysius, SILVA, Eveline, Kandiah, Nagaendran. Voluntary Cognitive Screening: Characteristics of participants in an Asian Setting. Clinical Interventions in Ageing. Clin Interv Aging. 2015 Apr 20; 10:771-80.
  • Elijah Mak, Helen Zhou, Tan LCS, Au Wing Lok, Sitoh Yih Yian, Nagaendran Kandiah. Cognitive deficits in mild Parkinson's disease are associated with distinct areas of grey matter atrophy. 2013 Oct 16. J Neurol Neurosurg Psychiatry.
  • Tze Pin Ng, Lei Feng, Wee Shiong Lim, Mei Sian Chong, Tih Shih Lee, Tung Tsoi, Tau Ming Liew, Qi Gao1, Simon Collinson, Nagaendren Kandiah, Philip Yap. Montreal Cognitive Assessment for Screening Mild Cognitive Impairment: Variations in Test Performance and Scores by Education in Singapore. Dementia Geriatric Cognitive Disorders. 2014, in press
  • Ng KP, Ng A, Assam P, Heng E, Kandiah N. Role of Cognitive Enhancer Therapy in Alzheimer's Disease with Concomitant Cerebral White Matter Disease: Findings from a Long-Term Naturalistic Study. Drugs R D. 2014 Jul 26. Epub ahead of print
  • Mak E, Bergsland N, Dwyer MG, Zivadinov R, Kandiah N. Subcortical Atrophy Is Associated with Cognitive Impairment in Mild Parkinson Disease: A Combined Investigation of Volumetric Changes, Cortical Thickness, and Vertex-Based Shape Analysis. AJNR Am J Neuroradiol. 2014 Jul 31. Epub ahead of print
  • Ting SK, Chong MS, Nagaendran Kandiah, Shahul Hameed, Tan LCS, Au Wing Lok, Prakash Kumar, Pavanni R, Lee TS, Foo JN, Bei JX, Yu XQ, Liu JJ, Zhao Y, Lee WL, Tan EK.Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases. Neurobiol Aging. 2013 Oct;34(10):2441.e7-8.
  • Kandiah N, et al. Cerebral white matter hyperintensity in Parkinson's disease: a major risk factor for mild cognitive impairment. Parkinsonism Relat Disord. 2013:680-3
  • Nagaendran Kandiah, et al. Hyperglycemic choreoathetosis: role of the putamen in pathogenesis. N. Mov Disord. 2009 Apr 30;24(6):915-9.
  • Tan K, Tan NC, Kandiah N, Samarasekera D, Ponnamperuma G. Validating a script concordance test for assessing neurological localization and emergencies. Eur J Neurol. 2014 Feb 1.
  • Narasimhalu K, Wiryasaputra L, Sitoh YY, Kandiah N. Post-stroke subjective cognitive impairment is associated with acute lacunar infarcts in the basal ganglia. Eur J Neurol. 2013 Mar;20(3):547-51.
  • Nagaendran Kandiah, et al. Creutzfeldt - Jakob disease: Which Diffusion-weighted Imaging Abnormality is Associated with a Periodic EEG Pattern? J Neurol. 2008 Sep;255(9):1411-4.
  • Ng A, Chew I, Narasimhalu K, Kandiah N. Effectiveness of Montreal Cognitive Assessment for the diagnosis of mild cognitive impairment and mild Alzheimer's disease in Singapore. Singapore Med J. 2013 Nov;54(11):616-9
  • Prasad K, Wiryasaputra L, Ng A, Kandiah N. White matter disease independently predicts progression from mild cognitive impairment to Alzheimer's disease in a clinic cohort. Dement Geriatr Cogn Disord. 2011;31(6):431-4.
  • Nagaendran K, Chen LH, Chong MS, Chua EV, Goh CK, Kua J, Lee T, Shiong LW, Marziyana AR, Ng CC, Ng LL, Seow D, Sitoh YY, Yap LK, Yeo D, Yeo Y. Ministry of health clinical practice guidelines: dementia. Singapore Med J. 2013 May;54(5):293-8.
  • Kandiah N, et al. Frontal subcortical ischemia is crucial for post stroke cognitive impairment. J Neurol Sci. 2011 Oct 15;309(1-2):92-5.
  • Kandiah N, et al. Carotid Stenosis: A Risk Factor for Cerebral White-matter Disease. J Stroke Cerebrovasc Dis. 2012 Dec 19.
  • Ng A, Earnest A, Yeo D, Kandiah N. Cognitive screening in Asia: recognizing the role of the patient-family unit. Dement Geriatr Cogn Disord. 2010;29:351-5.
  • Kandiah N, et al. Cognitive decline in early Parkinson's disease. Mov Disord. 2009 Mar 15;24(4):605-8.
  • Tan YL, Ng A, Kandiah N. Frontotemporal dementia in southeast Asia: a comparative study. Dement Geriatr Cogn Dis Extra. 2013 Jan;3(1):1-9
  • Chin R, Ng A, Narasimhalu K, Kandiah N. Utility of the AD8 as a self-rating tool for cognitive impairment in an Asian population. Am J Alzheimers Dis Other Demen. 2013 May;28(3):284-8.
  • Kandiah N, et al. Rapidly progressive dementia in a Chinese patient due to C90RF72 mutation. Can J Neurol Sci. 2012 Sep;39(5):676-7.
  • Chan LG, Kandiah N, Chua A. HIV-associated neurocognitive disorders (HAND) in a South Asian population - contextual application of the 2007 criteria. BMJ Open. 2012 Feb 13;2(1).
  • Tan NC, Kandiah N, Chan YH, Umapathi T, Lee SH, Tan K. A controlled study of team-based learning for undergraduate clinical neurology education. BMC Med Educ. 2011 Oct 30;11:91.
  • Kandiah N, Narasimhalu K, Lee J, Chen CL. Differences exist in the cognitive profile of mild Alzheimer's disease and subcortical ischemic vascular dementia. Dement Geriatr Cogn Disord. 2009;27(5):399-403.
  • Kandiah N, Feldman HH. Therapeutic potential of statins in Alzheimer's disease. J Neurol Sci. 2009 Aug 15;283(1-2):230-4
  • Feldman HH, Kandiah N. Early identification of Alzheimer's disease: what have we learned from mild cognitive impairment? CNS Spectr. 2008;13:4-7.

Research Trials

  • Study to elucidate the influence of Cerebral White Matter Disease in the pathogenesis of Alzheimer’s disease and Parkinson’s disease Dementia with combined Structural-Functional Neuroimaging. NMRC 2014-2018
  • Singapore Young Onset Dementia Cohort Study. NMRC 2015-2018, SGD 1.5 Million
  • Study into Clinical Effects and Pathophysiology of Vitamin (B1, B12, D) Deficiency in Mild Cognitive Impairment and Alzheimer’s disease". NNI HREF, 2017-2020
  • Multimodal Connectome analyses for differentiating subtypes within early stage dementia, BMRC-ASTAR 2013
  • Computerized 3- dimension cognitive software: Applicability for cognitive evaluation and cognitive rehabilitation. Singhealth Foundation-Media Development Authority 2010
  • Association of Vitamin D, white matter cerebral disease and APOE4 in Mild Cognitive Impairment. Singhealth Foundation, 2011
  • The influence of small vessel cerebrovascular lesions on cognition and tau pathology in Parkinson’s disease. NMRC 2013
  • Development of a visual cognitive assessment tool. Singhealth Foundation, 2013
  • Principal Investigator of Clinical Trials
    • A Double – Blind, Placebo- Controlled, Randomized, Parallel Group, 12 – Month Safety and efficacy trial of Leuco-methylthioninium bis(hydromethinesulfonate) in subjects with Behavioural Variant Frontotemporal Dementia (bvFTD)
    • A Multi- center, Double- blind, placebo- controlled, randomized, parallel- group phase 3 study to evaluate the safety and efficacy of Masitinib in patients with mild to moderate Alzheimer’s Diseasw
    • Randomized, Double – Blind, Placebo – Controlled, Parallel – Group, 12 – Month Trial of Leuco-methylthioninium bis (hydromethanesulfonate) in Subjects with Mild to Moderate Alzheimer’s Disease
    • A Multi-National Observational Study to Identify Treatment Discontinuation Rate in De Novo Alzheimer's Disease Patient Who is Newly Prescribed with Donepezil (Aricept®) in Asia [ART-M082-602]
    •  Randomized, Double-blind, Parallel-group, Placebo-controlled Study of Lu AE58054 in Patients with Mild-Moderate Alzheimer's Disease Treated with an Acetylcholinesterase Inhibitor; Study 3  [14863A]
    • An Open-label, Extension Study of the Effects of Leuco-methylthioninium bis(hydromethanesulfonate) in Subjects with Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia [TRx-237-020]
    • Open Label Trial of Rivastigmine Patch in Subjects with Mild to Moderate Stage Alzheimer's Disease Having Coexisting Small Vessel Cerebrovascular Disease
    • NEURoaid II (MLC 901) Assessment in Cognitively Impaired Not Demented Subjects: A Pilot Double Blind, Placebo-controlled Randomized Trial on Efficacy and Safety (NEURITES) Study [MLC 901-1]