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Prof Ian Yeo

Prof Yeo Yew San Ian

MBBS, M Med(Ophth), FRCS(Ed), FRCS(Glasg), FAMS

Senior Consultant

Singapore National Eye Centre

Specialty: Medical Retina, Surgical Retina, Cataract & Comprehensive Ophthalmology

Sub-specialties: Medical Retina, Surgical Retina, Cataract & Comprehensive Ophthalmology

Clinical Appointments

  • Senior Consultant Medical Retina Department Singapore National Eye CentreSingapore National Eye Centre
  • Senior Consultant Surgical Retina Department Singapore National Eye CentreSingapore National Eye Centre
  • Senior Consultant Cataract & Comprehensive Ophthalmology Department Singapore National Eye CentreSingapore National Eye Centre
  • Senior Consultant SNEC Eye Clinic @ CGH Changi General HospitalChangi General Hospital

Academic Appointments

  • Professor SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme
  • Professor, Kwan Im Thong Hood Cho Professorship in Ophthalmology Academic Medicine SingHealth Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme


Professor Yeo obtained his Medical Degree from the National University of Singapore in 1992. He did Ophthalmology residency training in Singapore. He obtained his post-graduate Ophthalmology qualifications in 1999 and completed a further 3 years of advance surgical training. He obtained his specialist accreditation in 2003 and started to pursue a vitreoretina subspecialty training at the Singapore National Eye Centre under Prof Ang Chong Lye. In 2006, he was awarded a HMDP grant to further his vitreoretinal training in Sydney, Australia under Drs Andrew Chang and Paul Beaumont. He is currently a senior consultant vitreoretinal surgeon managing both medical and surgical retina conditions at the Singapore National Eye Centre. He is also a clinical lecturer with the NUS-YLL medical school.

Professor Yeo is a Senior Adjunct Scientist with the Singapore Eye Research Institute. His research interest includes age related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV), two very important blinding conditions in Singapore. He has engaged in primate work developing animal models for AMD and looked at novel new strategies for delivering drugs for the condition under the retina. SNEC has collaborated with the Genomic Institute of Singapore to study the genetics of AMD and PCV. He is also a Principal Investigator for a number of international clinical trials for these 2 conditions.
His other research interests include retinovascular conditions including diabetic retinopathy. He is actively involved in clinical trials for these conditions as a co-investigator.


  • FAMS
  • M Med(Ophth) (2000)
  • FRCS(Ed) (1999)
  • FRCS(Glasg) (1999)
  • MBBS (1992)

Professional Appointments and Committee Memberships

  • Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore
  • Member, M Med (Ophthalmology) Committee, Division of Graduate Medical Studies, National University of Singapore
  • Physician Faculty Member, Ophthalmology Residency Program, SingHealth (2018)
  • Co-Chairman, Data Governance Committee, SingHealth (2017 - present)
  • Member, College of Clinical Medicine Education Council, SingHealth (2017 - present)
  • Board Director, Project Orbis International Inc. (Singapore) Ltd (2017 - present)
  • Committee Member, Medical Retina Subspecialty Committee, Singapore National Eye Centre (2016 - present)
  • Member, Executive Committee, Singapore National Eye Centre (2015 - present)
  • Member, Education Council Committee, SingHealth (2015 - present)
  • Committee Member, Residency Advisory Committee (RAC) for Ophthalmology, Ministry of Health (2015 - present)
  • Committee Member, APAO Steering Committee (2015 - present)
  • Committee Member, Evaluation Committee for the SNEC/SERI Clinical Academic Fellowship for Medical Officers (2015 - present)
  • Committee Member, Academy of Medicine Singapore, Chapter of Clinician Educators (2014)
  • Member, Management Committee (SNEC HEF & HREF), Singapore National Eye Centre (2014 - present)
  • Member, Education Research Working Committee, Singapore National Eye Centre (2014 - present)
  • Member, Richard Fan Lectureship Committee, Richard Fan Lectureship in Ophthalmology and Visual Sciences, Singapore National Eye Centre (2014 - present)
  • Committee Member, Richard Fan Gold Medal in Ophthalmology for Outstanding Senior Resident Selection Committee, Singapore National Eye Centre (2014 - present)
  • IT Committee Advisor, Singapore National Eye Centre (2014 - present)
  • Member, HMDP Committee Panel, HMDP sub Committee (Medicine and Surgery), Ministry of Health (2012 - present)
  • Member, Sub-committee for hospital doctors on pay matters, Ministry of Health (2012 - present)
  • Co-Chairman, SingHealth Cluster Compensation Committee (CCC), SingHealth (2012 - present)
  • Member, Academy of Medicine Singapore, College of Ophthalmologists (2010 - present)
  • Member, American Society of Retinal Surgeons (2009 - present)
  • Member, American Society of Cataract and Refractive Surgeons (2004 - present)
  • Fellow, Academy of Singapore (2004 - present)
  • Member, American Academic of Ophthalmology (2000 - present)
  • Member, Singapore Society of Ophthalmology (1995 - present)
  • Member, Singapore Medical Association (1992 - present)


  • Awards for Excellence for Outstanding Achievement in Enrolment for the CEDAR Study (2017)
  • Gold Award, Singapore Health Quality Service Award, SingHealth (2017)
  • GEM Award (2017) 
  • Achievement Award, Asia-Pacific Academy of Ophthalmology (APAO) (2017)
  • Silver Award, Singapore Health Quality Service Award, SingHealth (2016)
  • Doctors Long Service Award, SingHealth (2016)
  • Faculty Appreciation Award, SingHealth Excels (RiSE) Awards (2015)
  • GEM Award (2015)
  • GCEO Excellence Award – Outstanding Educator Award, SingHealth (2013)
  • Outstanding Research Mentor, Wong Hock Boon Society (2013)
  • Service Excellence - STAR Award, SingHealth (2012)
  • Ophthalmology Residency Pioneering Graduate Medical Education, SingHealth Excels (RiSE) Awards (2012)
  • Best Residency Programmes, SingHealth (2011)
  • Gold Award, SingHealth Service Excellence (2011)
  • Gold Award, SingHealth Service Excellence (2010)
  • Best Teacher Award - Senior Consultant (2010)
  • Best Teacher Award - Registrar (2001)

Research Interests


  1. Ting DS, Ng WY, Ng SR, Tan SP, Yeo IY, Mathur R, Chan CM, Tan AC, Tan GS, Wong TY, Cheung CM. Choroidal Thickness Changes in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy: A 12-month Prospective Study. Am J Ophthalmol. 2015 Dec 29. pii: S0002-9394(15)30029-5. doi: 10.1016/j.ajo.2015.12.024

  2. Lim FP, Wong CW, Loh BK, Chan CM, Yeo I, Lee SY, Mathur R, Wong D, Wong TY, Cheung CM. Prevalence and clinical correlates of focal choroidal excavation in eyes with age-related macular degeneration, polypoidal choroidal vasculopathy and central serous chorioretinopathy. Br J Ophthalmol. 2015 Oct 26. pii: bjophthalmol-2015-307055. doi: 10.1136/bjophthalmol-2015-307055

  3. Lim LS, Ng WY, Mathur R, Wong D, Wong EY, Yeo I, Cheung CM, Lee SY, Wong TY, Papakostas TD, Kim LA. Conversion to aflibercept for diabetic macular edema unresponsive to ranibizumab or bevacizumab. Clin Ophthalmol. 2015 Sep 16;9:1715-8

  4. Ting DS, Cheung GC, Lim LS, Yeo IY. Comparison of swept source optical coherence tomography and spectral domain optical coherence tomography in polypoidal choroidal vasculopathy. Clin Experiment Ophthalmol. 2015 Dec;43(9):815-9. doi: 10.1111/ceo.12580. Epub 2015 Aug 6

  5. Lim LS, Ng WY, Wong D, Wong E, Yeo I, Ang CL, Kim L, Vavvas D, Lee SY. Prognostic factor analysis of vitrectomy for myopic foveoschisis. Br J Ophthalmol. 2015 Dec;99(12):1639-43. doi: 10.1136/bjophthalmol-2015-306885. Epub 2015 Jul 2

  6. Ting DS, Tan S, Lee SY, Rosman M, Aw AT, Yeo IY. Extracapsular cataract extraction training: junior ophthalmology residents' self-reported satisfaction level with their proficiency and initial learning barrier. Postgrad Med J. 2015 Jul;91(1077):368-72. doi: 10.1136/postgradmedj-2014-132961. Epub 2015 Jun 9

  7. Wong CW, Yeo IY, Loh BK, Wong EY, Wong DW, Ong SG, Ang CL, Lee SY. Scleral buckling versus vitrectomy in the management of macula-off primary rhegmatogenous retina detachment : A comparison of visual outcomes. Retina. 2015 Dec;35(12):2552-7. doi: 10.1097/IAE.0000000000000642

  8. Wong CW, Cheung CM, Mathur R, Li X, Chan CM, Yeo I, Wong E, Lee SY, Wong D, Wong TY.Three-Year results of polypoidal choroidal vasculopathy treated with photodynamic therapy: Retrospective Study and Systematic Review. Retina. 2015 Aug;35(8):1577-93. doi: 0.1097/IAE.0000000000000499

  9. Ng WY, Cheung CM, Mathur R, Chan CM, Yeo IY, Wong E, Lee SY, Loh BK, Wong D, Wong TY. Trends in age-related macular degeneration management in Singapore. Optom Vis Sci. 2014 Aug;91(8):872-7

  10. Cheng CY, Yamashiro K, Jia Chen L, Ahn J, Huang L, Huang L, Cheung CM, Miyake M, Cackett PD, Yeo IY, Laude A, Mathur R, Pang J, Sim KS, Koh AH, Chen P, Lee SY, Wong D, Chan CM, Loh BK, Sun Y, Davila S, Nakata I, Nakanishi H, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, Matsuda F, Mori K, Yoneya S, Sakurada Y, Iijima H, Iida T, Honda S, Lai TY, Tam P, Chen H, Tang S, Ding X, Wen F, Lu F, Zhang X, Shi Y, Zhao P, Zhao B, Sang J, Gong B, Dorajoo R, Yuan JM, Koh WP, van Dam RM, Friedlander Y, Lin Y, Hibberd ML, Foo JN, Wang N, Wong CH, Tan GS, Park SJ, Bhargava M, Gopal L, Naing T, Liao J, Guan Ong P, Mitchell P, Zhou P, Xie X, Liang J, Mei J, Jin X, Saw SM, Ozaki M, Mizoguchi T, Kurimoto Y, Woo SJ, Chung H, Yu HG, Shin JY, Park DH, Kim IT, Chang W, Sagong M, Lee SJ, Kim HW, Lee JE, Li Y, Liu J, Teo YY, Heng CK, Lim TH, Yang SK, Song K, Vithana EN, Aung T, Bei JX, Zeng YX, Tai ES, Li XX, Yang Z, Park KH, Pang CP, Yoshimura , Yin Wong , Khor CC,Nat Commun. 2015 Jan 28;6:6063 New loci and coding variants confer risk for age-related macular degeneration in East Asians

  11. Wong CW, Wong WL, Yeo IY, Loh BK, Wong EY, Wong DW, Ong SG, Ang CL, Lee SY. Trends and factors related to outcomes for primary rhegmatogenous retinal detachment surgery in a large Asian tertiary eye centre. Retina. 2013 Oct 28. Epub

  12. Laurence Shen Lim, Andrew Tsai, Doric Wong, Edmund Wong, Ian Yeo, Boon Kwang Loh, Chong Lye Ang, Sze Guan Ong, Shu Yen Lee Prognostic Factor Analysis of Vitrectomy for Retinal Detachment Associated with Myopic Macular Holes Ophthalmology. August 22, 2013

  13. Gemmy Cheung CM, Yeo I, Li X, Mathur R, Lee SY, Chan CM, Wong D, Wong TY. Argon laser with and without anti-vascular endothelial growth factor therapy for extrafoveal polypoidal choroidal vasculopathy. Am J Ophthalmol. 2013 Feb;155(2):295-304. Epub 2012 Oct 27

  14. Isao Nakata, Kenji Yamashiro, Yumiko Akagi-Kurashige, Masahiro Miyake, Kyoko Kumagai, Akitaka Tsujikawa, Ke Liu, Li Jia Chen, David T.L. Liu, Timothy Y.Y. Lai, Yoichi Sakurada, Seigo Yoneyama, Ching-Yu Cheng, Peter Cackett, Ian Y. Yeo, Wan Ting Tay, Belinda K. Cornes, Eranga N. Vithana, Tin Aung, Keitaro Matsuo, Fumihiko Matsuda, Tien-Yin Wong, Hiroyuki Iijima, Chi Pui Pang, and Nagahisa Yoshimura. Association of Genetic Variants on 8p21 and 4q12 with Age-related Macular Degeneration in Asian Populations IOVS IOVS-12-10219;- Published ahead of print August 28, 2012, doi:10.1167/iovs.12-10219

  15. Ng WY, Wong DW, Yeo IY, Han DC. Cystoid Macular Edema in Acute Presentation of Central Retinal Artery Occlusion," Case Rep Ophthalmol Med. 2012;2012:530128. Epub 2012 Apr 4

  16. Lai CM, Estcourt MJ, Himbeck RP, Lee SY, Yew-San Yeo I, Luu C, Loh BK, Lee MW, Barathi A, Villano J, Ang CL, van der Most RG, Constable IJ, Dismuke D, Samulski RJ, Degli-Esposti MA, Rakoczy EP. Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates. Gene Ther. 2011 Nov 10. doi: 10.1038/gt.2011.169

  17. Ecosse L Lamoureux, Paul Mitchell, Gwyn Rees, Gemmy Cheung, Ian Yeo, Shu Yen Lee, Erica Liu, Tien Y Wong.  Impact of early and late age-related macular degeneration on vision-specific functioning. Br J Ophthalmol May 2011

  18. Chui Ming Gemmy Cheung, Ian YS Yeo, Adrian Koh. Photoreceptor changes in acute and resolved Acute Posterior Multifocal Placoid Pigment Epitheliopathy documented by Spectral-Domain OCT Arch. Ophthalmol. May 2010

  19. Boon Kwang Loh, Shu Yen Lee, Jacob Cheng, Ian Yeo, Doric Wong, Chong Lye Ang. Intravitreal bevacizumab for the treatment of myopic choroidal neovascularisation in an Asian population. Ann. Acad. Med. Singap. Jun 2010

  20. Augustinus Laudea, Peter D. Cackett, Eranga N. Vithanac, Ian Y. Yeo, Doric Wong, Adrian H. Koh Tien Y. Wong and Tin Aung. Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: Same or different disease? Progress in Retinal and Eye Research. Volume 29, Issue 1, January 2010, Pages 19-29

Research Trials