Profile
A/Prof Helen Chen is Senior Consultant Psychiatrist in Department of Psychological Medicine, KK Women's and Children's Hospital and Clinical Associate Professor, Duke-NUS Graduate Medical School. She is also the Programme Director of the Postnatal Depression Intervention Programme, a MOH-funded project that aims to screen for Postnatal Depression amongst a cohort of recently delivered women for the purpose of early intervention. She completed her training in the area of perinatal psychiatry and womenâs mental health in UK at the Queenâs Medical Centre, University of Nottingham, and has many years of clinical experience working with women suffering from mental health difficulties related to childbearing. Her research, publication and teaching experience has been particular related to emotional and psychological health issues in women, particularly in the context of motherhood, as well as empowering women to cope well with life challenges. Her experiences have humbled her, and made her respectful of the courage and perseverance of the spirit of her patients.
Education
- Grad Dip Psychotherapy 2001
- MMed Psychiatry 2001
- MBBS National University of Singapore 1995
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Professional Appointments and Committee Memberships
- Head, Department of Psychological Medicine, KK Womenâs and Childrenâs Hospital, 2012-2023
- Head, Senior Consultant Psychiatrist, Mental Wellness Service, KK Womenâs and Childrenâs Hospital, 2006-2012
- Director, Postnatal Depression Intervention Programme, 2008 till present
- Committee member, National Mental Health Workgroup, 2012 till present
- Member, Visitorâs Board, Institute of Mental Health, 2016 till present
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Awards
- SingHealth Health Quality Star Award â 2012, Singapore
- SingHealth GCEO Outstanding Clinician Award â 2011, Singapore
- SingHealth Health Quality Star Award â 2009-2010, Singapore
- SPRING EXSA Star Award â 2009, Singapore
- SPRING EXSA Gold Award â 2008, Singapore
- KKH Service from the Heart Award - FY2008 QTR3, Singapore
- KKH Service from the Heart Award - FY2007 QTR4, Singapore
- Thrice NHG Service Champion Award â for 1st quarter, Jul 2005 to Sep 2005,
- HMDP Fellowship to UK in Perinatal Psychiatry and Womenâs Mental Health â 2004, UK
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Research Interests
- Perinatal Depression
- Impact of maternal mental health on child development
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Publications
- "Improving mother-infant bonding in postnatal depression â The SURE MUMS study" Loh, A. H. Y., Ong, L. L., Yong, F. S. H., & Chen, H. Y. Asian J Psychiatry, 81, 103457. https://doi.org/10.1016/j.ajp.2023.103457. Published on 7 Jan 2023. (IF 6.59)
- âMid-pregnancy and postpartum maternal mental health and infant sleep in the first year of lifeâ Shirong Cai, Desiree Y. Phua, Elaine K. H. Tham, Daniel Y. T. Goh, Oon H. Teoh, Lynette P. C. Shek, Kok H. Tan, Fabian Yap, Yap-Seng Chong, Helen Chen, Birit F. P. Broekman, Michael S. Kramer, Michael J. Meaney. J Sleep Res. 2022;e13804. DOI: 10.1111/jsr.13804, published 13 Dec 2022. (IF 5.56)
- âEffects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathwaysâ Uy, J. P., Tan, A. P., Broeckman, B., Gluckman, P. D., Chong, Y. S., Chen, H., Fortier, M. V., Meaney, M. J., & Callaghan, B. L. J Child Psychol Psychiatry. https://doi.org/10.1111/jcpp.13721 (Nov 2022).(IF 8.265)
- âThe effect of older sibling, postnatal maternal stress, and household factors on language development in two to four year-old childrenâ Havron N, Lovcevic I, Kee MZL, Chen H, Chong YS, Daniel M, Broekman BFP, Tsuji S. Developmental Psychology 2022; doi:10.31219.osf.io.zye79 (IF 3.845)
- âFetal sex-specific epigenetic associations with prenatal maternal depressive symptomsâ Kee MZL, Teh AL, Clappison A, Pokhvisneva I, Maclssac JL, Lin DTS, Ramodori KE, Broekman BFP, Chen H, Daniel ML, Karnani N, Kobor M, Gluckman PD, Chong YS, Huang JY, Meaney MJ. iSCIENCE-D-22-00267R2 doi:10.2139/ssrn.4016766 (July 2022) (IF 6.107)
- âTele-Balint under the microscope: What really happens in Tele-Balint groups?â Jane Y. Pan, Flora S.H. Yong, Tze-Ern Chua, Helen Y. Chen. The International Journal of Psychiatry in Medicine. https://doi.org/10.1177/00912174221092505, published 2 May 2022. (IF 1.21)
- âA Prospective Study of the Relationship Between Sleep Quality and Depression in Pregnancyâ Chan, C., S. H. Poon, T. E. Chua, N. S. Razali, K. H. Tan and H. Chen. SAGE journals / Proceedings of Singapore Healthcare 2022, Vol. 0(0) 1â7 DOI: 10.1177/20101058211068591, published online 12 Jan 2022
- âPerceived stress during labor and its association with depressive symptomatology, anxiety, and pain catastrophizingâ Hon Sen Tan, T. Agarthesh, Chin Wen Tan, Rehena Sultana, Helen Yu Chen, TzeâErn Chua & Ban Leong Sng. Scientific Reports Nature Portfolio, manuscript accepted 13 Aug 2021, published 20 Aug 2021.(IF 4.38)
- âAssociation of Childbirth Pain with Postnatal Depressive and Anxiety Disorders in Nulliparous Parturients: A Prospective Studyâ Chin Wen Tan, Hon Sen Tan, Rehena Sultana, Anne Chui, Tze-Ern Chua, Helen Chen & Ban Leong Sng. Neuropsychiatric Disease and Treatment, accepted 1 Aug 2021, published 13 Aug 2021.(IF 2.4)
- "Maternal expressions of positive emotion for children predicts children's respiratory sinus arrhythmia surrounding stress" Delgadillo, D., S. Boparai, S. D. Pressman, A. Goldstein, J. F. Bureau, S. Schmiedel, M. Backer, B. Broekman, K. Hian Tan, Y. S. Chong, H. Chen, A. K. Zalta, M. J. Meaney, A. Rifkin-Graboi, S. Tsotsi and J. L. Borelli. Dev Psychobiol. 2021 Jul;63(5):1225-1240. doi:10.1002/dev.22082, published July 2021; published online 5 Jan 2021.
- âPreschoolersâ emotion reactivity and regulation: links with maternal psychological distress and child behavior problemsâ Tsotsi S., Borelli J.L., Backer M., Veragoo N., Abdulla, N., Tan K.H., Chong Y.S., Chen H., Meaney M.J., Broekman B.F.P., Rifkin-Graboi A. (in press). Development & Psychopathology, manuscript accepted 20 June 2021.(IF 4.357)
- âFecundability in reproductive aged women at risk of sexual dysfunction and associated risk factors: a prospective preconception cohort study" Loy, S. L., C. W. Ku, Y. B. Cheung, K. M. Godfrey, Y. S. Chong, L. P. Shek, K. H. Tan, F. K. P. Yap, J. Y. Bernard, H. Chen, S. Y. Chan, T. Y. Tan and J. K. Y. Chan (2021). BMC Pregnancy and Childbirth 21(1): 444., manuscript accepted 21 May 2021, published on 25 June 2021. (IF 2.94)
- âIncome disparity in school readiness and the mediating role of perinatal maternal mental health: a longitudinal birth cohort studyâ E. C. Law* , R. Aishworiya, S. Cai, A.-A. Bouvette-Turcot, B. F. P. Broekman, H. Chen, L. M. Daniel, P. D. Gluckman, L. P. C. Shek, S. K. H. Tay, Y. S. Chong, G. C.-H. Koh and M. J. Meaney. Epidemiology and Psychiatric Sciences (Cambridge University Press). DOI: https://doi.org/10.1017/S204579602000102X, accepted 30 Oct 2020, published online 8 Jan 2021.
- âMaternal expressions of positive emotion for children predicts childrenâs respiratory sinus arrhythymia surrounding stressâ Desiree Delgadillo, Sameen Boparai, Sarah D Pressman, Alison Goldstein, Jean-Francois Bureau, Sabrina Schmeidel, Mumtaz Backer, Kok Hian Tan, Yap-Seng Chong, Helen Chen, Alyson K Zalta, Michael J Meaney, Anne Rifkin-Graboi, Stella Tsotsi, Jessica L Borelli. Developmental Psychobiology 5 Jan 2021; https://doi.org/10.1002/dev.22082 (IF 2.94)
- âPreconception origins of perinatal maternal mental healthâ Kee MZL, Ponmudi S, Phua DY, Rifkin-Gabroi A, Chong YS, Tan KH, Chan JKY, Broekman BFP, Chen H, Meaney MJ. Archives of Womenâs Mental Health Jan 2021, doi.org/10.1007/s00737-020-01096-y (IF 4.34)
- âCohort profile: Singapore Preconception Study of Long-term Maternal and Child Outcomes (S-PRESTO)â Evelyn XL Loo, Shu-E Soh etâŠS-PRESTO Study Group: Helen Yu Chen et al. European J Epidemiology 2020; Nov(21); doi:10.1007/s10654-020-00697-2 (IF 7.14)
- âMultiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohortâ van Lee L, Chia A, Phua D, Colega M, Padmapriya N, Bernard JY, Cai S, Tham EKH, Teoh OH, Goh D, Gooley JJ, Gluckman PD, Yap F, Shek LPC, Godfrey KM, Tan KH, Chong YS, Muller-Riemenschneider F, Broekman B, Meaney M, Chen H, Chong MFF. Comprehensive Psychiatry 2020 Nov; 103:152210; doi:10.1016/j.comppsych.2020.152210.(IF 2.13)
- âChild and adolescent psychiatry telemedicine: A Singaporean experience born in Covid-19â Ngar Yee Poon, Shirley Pat Fong, Helen Yu Chen. Asian J Psychiatry 2020;Aug (53):102336; doi:10.1016/j.ajp.2020.102336 (IF 2.53)
- âNetwork Analyses of Maternal Pre- and Post-Partum Symptoms of Depression and Anxietyâ Desiree Y Phua, Helen Chen, Yap Seng Chong, Peter D Gluckman, Birit FP Broekman, Michael J Meaney. Frontiers Psychiatry 2020 Aug 6;11:785. Doi:10.3389/fpsyt.2020.00785. (IF 3.53)
- âAssociation of Pain Catastrophizing with Postnatal Depressive States in Nulliparous Parturients: A Prospective Studyâ Yanzhi Zeng*, Chin Wen Tan, Rehena Sultana, Tze-Ern Chua, Helen Yu Chen, Alex Tiong Heng Sia, Ban Leong Sng. Neuropsychiatric Disease and Treatment (Dovepress), 2020 Jul;30(16):1853-1862. Doi:10.2147/NDT/S256465, accepted 13 July 2020, published 30 July 2020. (IF 2.23)
- âFactors Associated with the Development of Postnatal Depression After Cesarean Delivery: Prospective Studyâ Carolyn Li-Jen Chan, Chin Wen Tan, Jason Ju In Chan, Rehena Sultana, Tze-Ern Chua, Helen Yu Chen, Alex Tiong Heng Sia, Ban Leong Sng. Neuropsychiatric Disease and Treatment (Dovepress). https://doi.org/10.2147/NDT.S241984, accepted 3 Mar 2020, published online 12 Mar 2020. (IF 2.23)
- âMaternal Antenatal Anxiety and Electrophysiological Functioning amongst a Sub-set of Preschoolers Participating in the GUSTO cohortâ Hong Kuang Tan; Shaun K.Y. Goh; Stella Tsotsi; Michaela Bruntraeger; Helen YU Chen; Birit Broekman; Kok Hian Tan; Yap Seng Chong; Michael J. Meaney; Anqi Qiu; Anne Rifkin-Graboi. BMC Psychiatry accepted 2020 Jan (IF 2.66)
- âIdentifying trajectories of antenatal depression in women and their associations with gestational age and neonatal anthropometry: A prospective cohort studyâ Haikel A. Lim*, Tze-Ern Chua, Rahul Malhotra, John C. Allen, Irene Teo, Bernard S. M. Chern, Kok Hian Tan, Helen Chen. General Hospital Psychiatry, Elsevier. https://doi.org/10.1016/j.genhosppsych.2019.09.001, accepted 11 Sep 2019, published online 12 Sep 2019. (IF 3.220)
- âCaring for the mother-child dyad as a family physician.â Tsang LPM, Ng DCC, Chan YH, Chen HY. Singapore Med J. 2019 Oct;60(10):497-501. doi: 10.11622/smedj.2019128. PMID: 31663104
- âTrajectories of antenatal maternal psychological stress and their association with gestational age and neonatal anthropometry: A prospective cohort study of multi-ethnic Asian women in an urban setting.â Lim HA, Chua TE, Malhotra R, Allen JC, Chern BSM, Tan KH, Chen H. Asian J Psychiatr. 2020 Feb;48:101923. doi: 10.1016/j.ajp.2019.101923. Epub 2019 Dec 28. PMID: 31896435
- âAn initial investigation of neonatal neuroanatomy, caregiving, and levels of disorganized behaviorâ Anne Rifkin-Graboi, Hui Min Tan, Goh Kok Yew Shaun, Lit Wee Sim, Shamini Sanmugam, Yap Seng Chong, Kok Hian Tan, Lynette Shek, Peter D. Gluckman, Helen Chen, Marielle Fortier, Michael J. Meaney, and Anqi Qiu. PNAS (Proceedings of National Academy of Sciences of the USA) https://doi.org/10.1073/pnas.1900362116. 2019 (IF 9.58)
- âMaternal Parenting Stress, Child Exuberance, and Preschoolersâ Behavior Problemsâ Stella Tsotsi, Birit F.P. Broekman, Lynette P. Shek, Kok Hian Tan, Yap Seng Chong, Helen Chen, Michael J. Meaney, and Anne E. Rifkin-Graboi. Child Development, January/February 2019, Volume 90, Number 1, Pages 136â146. (IF 5.02)
- âTelevision viewing and child cognition in a longitudinal birth cohort in Singapore: The role of maternal factorsâ Ramkumar Aishworiya, Shirong Cai, Helen Y. Chen, Desiree Y. Phua, Birit F.P. Broekman, Lourdes Mary Daniel, Yap Seng Chong, Lynette P. Shek, Fabian Yap, Shiao-Yng Chan, Michael J. Meaney, Evelyn C. Law. BMC Paediatrics accepted (IF 1.5
- "A cross-sectional survey of what patients find most therapeutic in perinatal mental healthcare in Singapore" Li Lian Ong, Ying Chia Ch'ng, Tze-Ern Chua, Helen Chen. Asian Journal of Psychiatry 2019 May 3;43:57-59. doi: 10.1016/j.ajp.2019.05.007(IF1.93)
- âGreater caregiving risk, better infant memory performance?â Rifkin-Graboi A, Quan J, Richmond J, Goh SKY, Sim LW, Chong YS, Bureau JF, Chen H, Qiu A. Hippocampus. 2018 Jul;28(7):497-511. doi: 10.1002/hipo.22949 (IF 3.27)
- âMaternal anxiety, parenting stress, and preschoolersâ behavior problems: the role of child self-regulationâ Tsotsi Stella, Broekman Birit, Sim Lit Wee, Shek Lynette, Tan Kok Hian, Chong Yap Seng, Qiu Anqi, Chen Helen, Meaney Michael, Rifkin-Graboi Anne. Journal of Developmental & Behavioural Pediatrics, accepted July 2019 (IF 2.39)
- âMaternal sensitivity during infancy and the regulation of startle in preschoolersâ Stella Tsotsi, Jessica L. Borelli, Nurshuhadah Binte Abdulla, Hui Min Tan, Lit Wee Sim, Shamini Sanmugam, Kok Hian Tan, Yap Seng Chong, Anqi Qiu, Helen Chen & Anne Rifkin-Graboi. ATTACHMENT & HUMAN DEVELOPMENT DOI: 10.1080/14616734.2018.1542737, accepted 28 Oct 2018, published online 8 Nov 2018. (IF 2.22)
- "Antenatal Anxiety: Prevalence and Patterns in a Routine Obstetric Population" Tze-Ern Chua, Dianne Carrol Bautista, Kok Hian Tan, George Yeo, Helen Chen. Annals Academy of Medicine Ann Acad Med Singapore 2018;47:405-12, accepted: 22 Oct 2018, published online Oct 2018.(IF 1.13)
- "Threatened Miscarriage and Depressive and Anxiety Symptoms among Women and Partners in Early Pregnancy" Cindy Shiqi Zhu, Tan Thiam Chye, Helen Yu Chen, Rahul Malhotra, John Carson Allen, Truls Ăstbye. Journal of Affective Disorders DOI: 10.1016/j.jad.2018.04.012, accepted 2 Apr 2018, published online 11 Apr 2018 (IF 3.43)
- âInvestigation of variants in estrogen receptor genes and perinatal depressionâ Ene-Choo Tan, Hwee-Woon Lim, Tze-Ern Chua, Hui-San Tan, Theresa MY Lee, Helen Y Chen. Dovepress, Neuropsychiatric Disease and Treatment 2018:14 919â925, accepted 9 Feb 2018, published 29 Mar 2018.(IF 1.74)
- âProspective associations of maternal dietary patterns and postpartum mental health in a multi-ethnic Asian cohort: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) studyâ Cherylen Teo, Ai-Ru Chia, Marjorelee T Colega, Ling-Wei Chen, Doris Fok, Wei Wei Pang, Keith M Godfrey, Kok Hian Tan, Fabian Yap, Lynette Pei-Chi Shek, Yap-Seng Chong, Michael Meaney, Helen Chen, Mary Foong-Fong Chong (2018) MDPI, Nutrients 2018, 10, 299; doi:10.3390/nu10030299, accepted on 28 Feb 2018, published 2 Mar 2018. (IF 4.74)
- âPsychotropic Prescription in Antenatal Depression, Anxiety and Adjustment Disorders in Singaporeâ Junpei Elizabeth Siak, Tze-Ern Chua, Sandy Julianty Umboh, Helen Chen. ASEAN Journal of Psychiatry, accepted on 5 Feb 2018.
- âChild, Maternal and Demographic Factors Influencing Caregiver-Reported Autistic Trait Symptomatology in Toddlersâ D. A. Goh, D. Gan, J. Kung, S. Baron-Cohen, C. Allison, H. Chen, S.M. Saw, Y. S. Chong, V. S. Rajadurai, K. H. Tan, P. C. L. Shek, et al. Journal of Autism and Developmental Disorders, accepted on 18 Jan 2018, Published online on 31 Jan 2018, DOI 10.1007/s10803-018-3471-7. (IF 2.51)
- âTrajectories of maternal prenatal stress, depression, and anxiety, and their association with prematurity and neonatal outcomesâ Lim, H. A., Chua, T. E., Malhotra, R., Allen, Jr., J. C., Teo, I., Tan, K. H., & Chen, H. (2018). European Psychiatry, 48, S216â217. (IF: 3.47)
- âPositive maternal mental health during pregnancy associated with specific forms of adaptive development in early childhood: Evidence from a longitudinal studyâ Phua DY, Kee MKZL, Koh DXP, Rifkin-Graboi A, Daniels M, Chen H, Chong YS, Broekman BFP, Magiati I, Karnani N, Pluess M, Meaney MJ. Dev Psychopathol. 2017 Dec;29(5):1573-1587. doi: 10.1017/S0954579417001249 (IF 3.59)
- âPsychopathology experienced in pregnancy loss: does post abortion syndrome exist?â Kah Wee Ng, Jintana Tang, Helen Chen, ASEAN Journal of Psychiatry, Vol. 18 (2), July - December 2017: XX-XX, accepted on 27 Nov 2017, published on 7 Dec 2017.
- âPerinatal Maternal Depressive Symptoms Alter Amygdala Functional Connectivity in Girlsâ Ni Ni Soe, Daniel J. Wen, Joann S. Poh, Yap-Seng Chong, Birit Fp Broekman, Helen Chen, Lynette P. Shek, Kok Hian Tan, Peter D. Gluckman, Marielle V. Fortier, Michael J. Meaney and Anqi Qiu, Human Brain Mapping, accepted on 26 Oct 2017, Published online on 2 Nov 2017, DOI: 10.1002/hbm.23873. (IF 5.97)
- âMaternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohortâ van Lee L, Quah PL, Saw SM, Yap FKP, Godfrey KM, Chong YS, Meaney MJ, Chen H, Chong MF. Depress Anxiety 2017 Oct; 34(10):877-887. doi:10.1002/da.22637.(IF 5.00)
- âFKBP5 moderates the association between Antenatal Maternal Depressive Symptoms and Neonatal Brain Morphologyâ Wang C, Shen M, Guillaume B, Chong YS, Chen H, Ortier MV, Meaney MJ, Qiu A. Neuropsychopharmacology 2017 Oct 3; doi:10.1038/npp.2017.232.(IF 6.40)
- âRelation of plasma tryptophan concentrations during pregnancy to maternal sleep and mental well-being: The GUSTO cohortâ Linde van Lee, Shirong Cai, See Ling Loy, Elaine K.H. Tham, Fabian K.P. Yap, Keith M. Godfrey, Peter D. Gluckman, Lynette P.C. Shek, Oon Hoe Teoh, Daniel Y.T. Goh, Kok Hian Tan, Yap Seng Chong, Michael J. Meaney, Helen Chen, Birit F.P. Broekman, Mary F.F. Chong, Journal of Affective Disorders, accepted on 21 August 2017, DOI: http://dx.doi.org/10.1016/j.jad.2017.08.069. (IF 3.57)
- âPolyunsaturated Fatty Acids in Perinatal Depression: A Systematic Review and Meta-Analysisâ Pao-Yen Lin, Cheng-Ho Cheng, Mary Foong-Fong Chong, Helen Chen, Kuan-Pin Su, Elsevier, accepted on 3 March 2017, DOI: 10.1016/j.biopsych.2017.02.1182. (IF 11.21)
- âInfluences of Prenatal and Postnatal Maternal Depression on Amygdala Volume and Microstructure in Young Childrenâ Daniel J. Wen, Joann Poh, Soe Ni Ni, Yap-Seng Chong, Helen Chen, Kenneth Kwek, Lynette P. Shek, Peter D. Gluckman, Marielle V. Fortier, Michael J. Meaney & Anqi Qiu, Translational Psychiatry, accepted on 23 February 2017.(IF 5.62)
- âUnderstanding How Postnatal Depression Screening and Early Intervention Works in the Real World â A Singaporean Perspectiveâ Theresa MY Lee, Dianne Bautista & Helen Y Chen, Annals Academy of Medicine, PND Intervention Programme 4-Year Audit, October 2016, Vol. 45 No. 1.(IF 1.04)
- âAssociation of physical activity and sedentary behavior with depression and anxiety symptoms during pregnancy in a multiethnic cohort of Asian womenâ Natarajan Padmapriya, Jonathan Y. Bernard, Shen Liang, See Ling Loy, Zhe Shen, Kenneth Kwek, Keith M. Godfrey & Peter D. Gluckman, Yap-Seng Chong, Seang Mei Saw, Michael J. Meaney, Helen Chen & Falk MĂŒller-Riemenschneider (On behalf of the GUSTO Study Group), Received: 26 March 2016 /Accepted: 2 September 2016, Arch Womens Ment Health, DOI 10.1007/s00737-016-0664-y.(2.62)
- "Anxiety and Depression during Pregnancy and Temperament in Early Infancy: Findings from a Multi-Ethnic, Asian, Prospective Birth Cohort Study" Shang-Chee Chong, Birit FP Broekman, Anqi Qiu, Izzuddin M. Aris, Yiong Huak Chan, Anne Rifkin-Graboi, Evelyn Law, Cornelia Yin Ing Chee, Yap-Seng Chong, Kenneth Y.C. Kwek, Seang Mei Saw, Peter D. Gluckman, Michael J. Meaney, Helen Chen; Infant Mental Health Journal Vol. 37(5), 584â598 (2016) DOI: 10.1002/imhj.2158.(1.07)
- "Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case control studyâ Thangavelautham S, Phuong Tu PH, Chen H, Tan EC, Pryseley NA, Sultana R, Han NL, Sng, BL, accepted Neuropsychiatric Disease and Treatment, Apr 2016. Published 9 June 2016. (IF 1.74)
- "Patterns and predictors of treatment outcome for antenatal major depression" Chua T E, Allen J, Ang L, Ong L L, Châng Y C, Chen H. Singapore Medical Journal ePub 1 Jun 2016. doi: 10.11622/smedj.201610.(IF 0.57)
- âPre- and Post-natal Maternal Depressive Symptoms in relation with infant frontal function, connectivity and behavioursâ Soe NN, Wen DJ, Poh JS, Yue Li, Broekman BF, Chen H, Chong YS, Kwek K, Saw SM, Gluckmann PG, Meaney MJ, Rifkin-Graboi A, Qiu A. accepted PLOS One, Mar 2016. Published 13 Apr 2016. doi: 10.1371/journal.pone.0152991.(IF 3.23)
- âMaternal sensitivity, infant limbic structure volume and functional connectivity: preliminary studyâ Rifkin-Graboi A, Kong L, Sim LW, Sanmugam, Broekman BFP, Chen H, Wong E, Kwek K, Chong YS, Gluckman PD et al; Translational Psychiatry 5(10):E668; DOI:10.1038/tp.2015.133.(IF 5.62)
- âAn independent association of prenatal depression with wheezing and anxiety with rhinitis in infancyâ Chen TS, Chen H, Lee T, Teoh OH, Shek L, Lee BW, Chee C, Godfrey KM, Gluckman PD et el. Pediatric Allergy and Immunology 2015:00; DOI:10:1111/pai.12453 (IF 3.40)
- âBrain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumesâ Chen L, Pan H, Tuan, TA, The AL, MacIsaac JL, Mah SM, McEwen LM, Li Y, Chen H, Broekman B, et al. Development and Psychopathology 2015;27:135-150; doi:10.1017/S0954579414001357. (IF 4.89)
- âRetrospective observation of mental disorders during postpartum period: Results from the Singapore mental health Studyâ Vathsala Sagayadevan*, Siau Pheng Lee, Edimansyah Abdin, Janhavi Vaingankar, Helen Chen, Siow Ann Chong and Mythily Subramaniam. BioMed Central Womenâs Health (2015)15:119; DOI 10.1186/s12905-015-0279-x. (IF 1.50)
- âCase control study of glucocorticoid receptor and corticotrophin-releasing hormone receptor gene variants and risk of perinatal depressionâ Ene-Choo Tan*, Tze-Ern Chua, Theresa M. Y. Lee, Hui-San Tan, Joe L. Y. Ting and Helen Y. Chen. BioMed Central Pregnancy & Childbirth (2015) 15:283 doi:10.1186/s12884-015-0720-z. Published 30 Oct 2015. (IF 2.19)
- "Antenatal Maternal Anxiety Predicts Variations in Neural Structures Implicated in Anxiety Disorders in Newborns" Anqi Qiu*, Anne Rifkin-Graboi, Michael J. Meaney, Helen Chen, Jordan Bai, Waseem Bakâr Hameed, Mya Thway Tint, Birit FP Broekman, Yap-Seng Chong, Peter D. Gluckman, Marielle V. Fortier. Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), accepted 28 Jan 2015. Volume 54, Issue 4, April 2015, Pages 313â321.e2. (IF 7.26)
- "Prenatal Maternal Depression Alters Amygdala Functional Connectivity in 6-month-old infants" Anqi Qiu*, Ta Anh Tuan, Yue Li, Helen Chen, Anne Rifkin-Graboi, Birit FP Broekman, Kenneth Kwek, Seang-Mei Saw, Yap-Seng Chong, Peter D. Gluckman, Marielle V. Fortier, Michael J. Meaney. Nature Translational Psychiatry, accepted Dec 2014. Translational Psychiatry (2015) 5, e508; doi:10.1038/tp.2015.3. (IF 5.62)
- "Long-chain polyunsaturated fatty acid status during pregnancy and maternal mental health in pregnancy and the postpartum period: results from the GUSTO study " Mary Foong-Fong Chong, Yi Lin Ong, Helen Chen, Chong Yap Seng, Marjorelee T. Colega, Peter GLUCKMAN_NZ, Keith Godfrey, Calder P.C., Tan Chuen Seng, Fisk H., Cai Shirong, Pang Wei Wei, Leutscher-Broekman, Saw Seang Mei, Kenneth Kwek, Michael MEANEY_Mcgill, Jocelyn Wong. Journal of Clinical Psychiatry, 2015; 76(7):e848-56 (IF 5.50)
- âRelationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study" Mary F.F. Chong, Jocelyn X.Y. Wong, Marjorelee Colega, Ling-Wei Chen, Rob M. van Dam, Chuen Seng Tan, Ai Lin Lim, Shirong Cai, Birit F.P. Broekman, Yung Seng Lee, Seang Mei Saw, Kenneth Kwek, Keith M. Godfrey, Yap Seng Chong, Peter Gluckman, Michael J. Meaney, Helen Chen. Journal of Psychiatric Research, 2014 55(April):110-116, doi: 10/1016/j.psychires.2014.04.006.(IF 4.66)
- âCOMT Haplotypes Modulate Associations of Antenatal Maternal Anxiety and Neonatal Cortical Morphologyâ A Qiu, T A Tuan, M L Ong, Y Li, A R-Graboi, H Chen, B FP Broekman, K Kwek, S-M Saw, Y-S Chong, P D. Gluckman, M V. Fortier, J D Holbrook, M J. Meaney, American Journal of Psychiatry 2015 Feb 31;172(20):163-72. Epub 2014 Oct 31. (IF 13.56)
- âAssociation of premenstrual/menstrual symptoms with perinatal depression and a polymorphic repeat in the polyglutamine tract of the retinoic acid induced 1 gene" Tan EC, Tan HS, Chua TE, Lee T, Ng J, Châng Y C, Choo C H, Chen H, Journal of Affective Disorders 2014 Jun; 161:43-6. Doi:10.1016/j.jad.2014.03.006. (IF 3.30).
- âPrenatal maternal depression associated with microstructure of right amygdala in neonates at birthâ Rifkin-Gabrol A, Bai J, Chen H, Hameed WB, Lit WS, Mya TT et al. Biological Psychiatry 2013 Dec1:74(11):837-44.doi:10.1016/j.biopsych.2013.06.019. (IF 10.26)
- âAntenatal mental health and retinal vascular caliber in pregnant womenâ Li LJ, Ikram MK, Broekman, Cheung CYL, Chen H, Gooley JJ, Soh SE, Gluckman P, Kwek K, Chong YS, Meaney M, Wong TY, Saw SM. Trans Vis Sci Tech 2013, doi:10.1167/tvst.2.2.2.
- âPostnatal depression: a family medicine perspectiveâ Umboh SJ, How CH, Chen H. Singapore Med J. 2013 Sep;54(9):477-9; quiz 480-1. doi: 10.11622/smedj.2013167
- âThe maternal infant dyadic relationship â looking beyond postpartum depressionâ Chen H, Lee T. Asean J Psychiatry 2013; 14(2):161-69.
- âAntenatal depression and anxiety in a high-risk pregnancyâ Chua TE, Wang J, Chen H. Asean J Psychiatry accepted 2013
- âScreening for postnatal depression in Chinese-speaking women using the Hong Kong translated version of the Edinburgh Postnatal Depression Scaleâ Chen H, Bautista D (joint first authors), Châng YC, Li WY, Chan E, Rush AJ. Asia Pac Psy, 2013, doi.10.1111/appy.12080
- âThe influence of anxiety in pregnancy on birth lengthâ Broekeman G, Chan YH, Kwek K, Cohan SS, Haley CL, Chee C, Chen H, Rifkin-Garbrol A, Gluckman P, Meaney M, Saw SM. PaedPerinEpid accepted 2013
- âPrevalence of depression and anxiety in high-risk pregnanciesâ Thiagayson P, Krishnasamy G, Sung S, Fung D, Allen J, Chen H. Gen Hospital Psychiatry 2012; 35(2):112-116
- âUnderstanding maternal mental illness: a case report â psychiatric autopsy of maternal suicideâ Chen H. Singapore Med Journal 2012 53(5):e1-e2
- âIdentifying mothers with postpartum depression early: integrating perinatal mental health care into the obstetric settingâ Chen et al. ISRN Obstetrics and Gynecology accepted 2011; doi:10.5402/2011/309189.
- âFrontline Report: Addressing maternal mental health needs in Singaporeâ Chen H. Psychiatric Services 2011, 62:102.
- âSupportive counselling for postpartum depression in Asiansâ Fam J, Wang J, Chen H. Asia Pacific Psychiatry 2011; 3:61-66.
- âRandomized comparison of selective serotonin reuptake inhibitor (escitalopram) monotherapy and antidepressant combination pharmacotherapy for major depressive disorder with melancholic features: a CO-MED reportâ Bobo WV, Chen H et al J Affective Disorders 2011; 133(3):467-76.
- âPerinatal Case Management: Caring for our mothers as they care for their babiesâ Châng YC, Wang J, Chen H, J PaedsObsGyn 2010, Nov/Dec:227-232.
- âHolistic Antenatal Care: Mental Wellness in Pregnancyâ Chen H. SMJ 2008;49(1 Suppl):S16 Medical Journal 2008;49(9):694-697
- âMaternal deaths from suicide in Singaporeâ Chen YH, Lau G. SMJ 2008;49(9):694-694.
- âWomenâs mental health â an overrated issue or under-recognised needâ Chen H. SMJ editorial, May 2007;48(5):378-379
- âDepressive symptomatology in pregnancy: a Singaporean perspectiveâ Chen H, Tan KH, Chan YH, Lee T. SocPsy Psych Epid 2004, 39:975-979.
- âReducing benzodiazepine prescription at point of dischargeâ Lee C, Ng BT, Eu PW, Chen H, Lee N, Foo R, Ithin MA. Ann Acad Med Singapore 2004;33(5):S97.
- âMental health literacy study of general practitioners: a comparative study in Singapore and Australiaâ Parker G, Lee C, Chen H, Kua J, Loh J, Jorm A. Australasian Psychiatry 2001, Mar 9(1):55-59
- âA comparative mental health literarch survey of psychiatrists and other mental health professionals in Singaporeâ Parker G, Chen H, Kua J, Loh J, Jorm A. Aust NZ J Psychiatry 2000 Aug;43(4):627-636
- âMental health literacy in Singapore: a comparative survey of psychiatrists and primary health professions.â Chen H, Parker G, Kua J, Jorm A, Loh J. Ann Acad Med Singapore 2000; Jul;29(4):467-73.
- âA clinical study of 7 cases of trichotillomania in Singaporeâ Fung DSS, Chen H. Ann Acad Med Singapore 1999;28(4):519-524
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Research Trials
- Prospective follow-up of women with mental health disorders - 2018 submitted
- Trajectories of Perinatal Stress, Depression, and Anxiety: Risk Factors and Associations with Neonatal Anthropometry â 2017
- Evaluation of the Supporting Resilience and Empowering Mums (SURE MUMS) pilot programme 2017
- Comparison of the role of epidural analgesia versus non-epidural analgesia in postnatal depression and persistent pain development â a randomized controlled trial - 2017
- Depression and Anxiety in Women Facing Threatened Miscarriage and Their Partners 2016
- Postnatal Depression and Post-traumatic Stress Disorder in Women following and Eventful Childbirth 2015
- The Caregiving and Development Project 2015
- Clinical Audit of the Postnatal Depression Intervention Programme 2008 till present
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