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Anti-Tumour Necrosis Factor (Anti-TNF)

Drug Class: Commonly Known As: Category:
Tumor Necrosis Factor Inhibitor Adult

Anti-Tumour Necrosis Factor (Anti-TNF) - What is it for

Anti-TNF is biological agent that targets an inflammation causing substance called TNF.  

When TNF is present in excessive concentrations, is responsible for the destructive inflammatory process that occur in RA.

It acts by blocking the effect of TNF. Thus, reduce inflammation and stop disease progression.

It is reserved for moderate to severe RA that has not responded to one or more of the traditional disease modifying anti-rheumatic drugs (DMARDs) such as methotrexate.

It is also used in psoriatic arthritis and ankylosing spondylitis.

There are five anti-TNF drugs available including Infliximab, Adalimumab, Etanercept, Certolizumab and Golimumab.

It may be used monotherapy (Adalimumab, Etanercept and Certolizumab) or in combination with DMARDs (all anti-TNF).

  • Updated on Friday, June 12, 2015
  • Article contributed by Pharmacy Singapore General Hospital

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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