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Drug Class: Commonly Known As: Category:
Angiotensin Receptor-Neprilysin Inhibitors (ARNi) Entresto Adult

Sacubitril/Valsartan - What is it for

Patients with heart failure which occurs when the heart is weak and unable to pump enough blood to the lungs and the rest of the body. This medicine reduces the risk of death and hospitalization in chronic heart failure.

It is usually used with other heart failure therapies, in place of an ACE inhibitor or ARB therapy.

Sacubitril/Valsartan - Side Effects, Precautions, and Contraindications

What side effects can Sacubitril/Valsartan cause?

  • Dizziness
  • Angioedema (swelling of face, lips, tongue or throat that results in trouble in breathing)
  • Your doctor may need to monitor you for electrolytes imbalances when you are on this medication

Before taking Sacubitril/Valsartan, what precautions must I follow?

  • Do not take sacubitril/valsartan for at least 36 hours before or after you take an ACE inhibitor medicine
  • Inform your doctor if you are taking these medications (potassium supplements, nonsteroidal anti-inflammatory drugs NSAIDs, lithium or other high blood pressure medications such as ACE inhibitor, ARB, aliskiren)
  • Inform your doctor if you have any kidney or liver problems.
  • Inform your doctor if you are pregnant, planning to conceive or if you are breast-feeding.

You should not take this medicine if you:

  • have allergy to any sacubitril, valsartan or any component of Entresto
  • have a history of angioedema related to previous ACE inhibitor or ARB therapy
  • are taking ACE inhibitors
  • are diabetic and taking aliskiren
  • are pregnant
  • are breastfeeding
  • have poor kidney function

What food or medicine must I avoid when I take Sacubitril/Valsartan?

Sacubitril/Valsartan - Dosage and How to Use

How should Sacubitril/Valsartan be used?

You should use this medication as told by your doctor or pharmacist

What should I do if I miss a dose?

  • If you miss a dose, take the missed dose as soon as you remember
  • If it is almost time for your next dose, take only the usual dose
  • Do not double the dosage

What should I do if I overdose?

Sacubitril/Valsartan - Handling and Storage

How should I handle Sacubitril/Valsartan safely?

How should I store Sacubitril/Valsartan?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Sacubitril/Valsartan safely?

Sacubitril/Valsartan - Additional Information

  • Updated on Tuesday, September 6, 2016
  • This article is contributed by Department of Pharmacy National Heart Centre Singapore

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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