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The synovial micro-enviroment in juvenile idiopathic arthritis

Major Category: Research and Disease Areas

Subcategory: Loss of Tolerance

By Leong Jing Yao (Team Lead), Lai Liyun, Phyllis Chen

The afflicted joints of juvenile idiopathic arthritic patients are characterised by high infiltration and expansion of a restricted T cell clonatype repertoire. This antigenic driven process limits the affliction to specific joints. It is unknown whether the presence of multiple affected joints within an individual are underscored by a common disease mechanism. We have in collaboration with Femke’s lab in Utrecht University, worked on the immunological phenotyping of disparate joints within each individual to answer this question. CyToF results indicate common immunological processes in the joints of the same individual and driven by a common antigenic force.