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Asst Prof Yip Siew Poh Connie

Asst Prof Yip Siew Poh Connie

MBChB (Hons), MRCP (UK), FRCR (UK), PhD (UK)

Senior Consultant

National Cancer Centre Singapore

Specialty: Radiation Oncology, Radiation Oncology

Clinical Interest: Thoracic-Oncology, Upper Gastrointestinal, Colorectal, Hepato-Pancreato-Biliary

Conditions Treated by this Doctor:
Bile Duct Cancer, Colorectal Cancer, Liver Cancer, Lung Cancer, Oesophagus Cancer, Pancreatic Cancer, Stomach Cancer, Thoracic Cancers.

Clinical Appointments

  • Senior Consultant Division of Radiation Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore

Academic Appointments

  • Duke-NUS Medical School
  • Yong Loo Lin School of Medicine

Profile

Dr Connie Yip is a Senior Consultant Radiation Oncologist with interests in gastrointestinal and thoracic malignancies. She graduated from the University of Dundee, UK with MBChB (Hons) and various medical awards in 2003. She subsequently completed her general medical training in Edinburgh and completed MRCP in 2006. She began her Radiation Oncology training at the National Cancer Centre Singapore and was awarded a 2-year HMDP fellowship from the Singapore Ministry of Health to pursue further training at Guy's and St Thomas' Hospital, London in 2011. She attained FRCR in Clinical Oncology in 2011. Following this, she was awarded the Clinical Research Fellowship funded by the Cancer Research UK and the NMRC Research Training Fellowship by the National Medical Research Council (Singapore) to pursue a PhD at King's College London in 2013. Her thesis entitled 'Imaging tumour heterogeneity and improving treatment response assessment in oesophageal cancer' was awarded the Cancer Research UK Pontecorvo Prize for Best PhD Thesis in 2018.  Her main research interests are (i) to evaluate for novel ways to combine radiation therapy with systemic/immunotherapy, (ii) the evaluation of downstream radiation-mediated immune and systemic responses, and (iii) the use of functional imaging to improve radiation treatment and response assessment in thoracic and gastrointestinal cancers.

Education

  • PhD in Imaging Sciences & Biomedical Engineering, King’s College London 
  • FRCR Clinical Oncology, Royal College of Radiologists UK 
  • MRCP, Royal College of Physicians Edinburgh, UK 
  • MBChB (Honours), University of Dundee Medical School, UK

Professional Appointments and Committee Memberships

Awards

  • Japanese Society of Medical Oncology Annual Meeting Travel Award
  • CRUK Pontecorvo Prize for best PhD thesis
  • NMRC Research Training Fellowship, National Medical Research Council, Singapore 
  • Clinical Research Fellowship, Comprehensive Cancer Imaging Centre, King’s College London funded by Cancer Research UK, Engineering & Physical Sciences Research Council, Medical Research Council and Department of Health (England) 
  • HMDP Fellowship in Clinical Oncology, Ministry of Health, Singapore 
  • Famuyiwa Fund Prize and RC Alexander Memorial Prize in Surgery, University of Dundee, UK

Research Interests

My main research interests are (i) to evaluate for novel ways to combine radiation therapy with systemic/immunotherapy, (ii) the evaluation of downstream radiation-mediated immune and systemic responses, and (iii) the use of functional imaging to improve radiation treatment and response assessment in thoracic and gastrointestinal cancers. My current research is focused on evaluating the changes in the immune microenvironment and systemic immune profiles following radiation in various cancer types, as well as the integration of radiation as a combinational therapy in HCC.

Publications

• Khin NS, Tan SH,…Yip C. Chemoradiation-induced changes in systemic inflammatory mark-ers and their prognostic significance in oesophageal squamous cell carcinoma. Br J Radiol 2021; 94: 20200314. DOI: 10.1259/bjr.20200314
• Yip C, Hennedige TP, Cook GJR, Goh V. Imaging assessment after SBRT for hepatocellular carcinoma. Hepatoma Research 2020;6:44.
• Knight WRC, Yip C, Wulangnisih W, et al. Prediction of a positive circumferential resection margin at surgery following neoadjuvant chemotherapy for adenocarcinoma of the oesopha-gus. BJS Open 2019;3:767-76.
• Yip C, Cook GJR, Owczarczyk K, Goh V. Challenges in imaging assessment following liver stereotactic body radiotherapy: pitfalls to avoid in clinical practice. Chin Clin Oncol 2017;6(Suppl 2):S11.
• Yip C, Weeks A, Shaw K, Siddique M, Chang F, Landau DB, Cook GJR, Goh V. Magnetic resonance imaging (MRI) of intratumoral voxel heterogeneity as a potential response bi-omarker: Assessment in a HER2+ esophageal adenocarcinoma xenograft following Trastuzumab and/or Cisplatin therapy. Transl Oncol 2017;10(3):459-467.
• Yip C, Cook GJR, Wee J, Fong KW, Tan T, Goh V. Clinical significance of hypoxia in naso-pharyngeal carcinoma with a focus on existing and novel hypoxia molecular imaging. Chin Clin Oncol 2016:5(2):24.
• Yip C, Cook GJR, Landau DB, Davies A, Goh V. The performance of different imaging mo-dalities in assessment of response to neoadjuvant therapy in primary esophageal cancer. Dis Esop 2016:29(2):116-130.
• Yip C, Tacelli N, Remy-Jardin M, Scherpereel A, Cortot A, Lafitte JJ, Wallyn F, Remy J, Bas-sett P, Siddique M, Cook GJR, Landau DB, Goh V. Imaging tumor response and tumoral het-erogeneity in non-small cell lung cancer treated with anti-angiogenic therapy: Comparison of the prognostic ability of RECIST 1.1, alternate method and image heterogeneity analysis. J Thorac Imaging 2015;30(5):300-7.
• Yip C, Dinkel C, Mahajan A, Siddique M, Cook GJR, Goh V. Imaging body composition in cancer patients: visceral obesity, sarcopenia and sarcopenic obesity may impact on clinical out-come. Insights Imaging 2015;6(4):489-97.
• Yip C, Davnall F, Kozarski R, Landau DB, Cook GJR, Ross P, Mason R, Goh V. Assessment of changes in tumor heterogeneity following neoadjuvant chemotherapy in primary esophageal cancer. Dis Esop 2015;28:172-179.
• Yip C, Blower PJ, Goh V, Landau DB, Cook GJR. Molecular imaging of hypoxia in non-small cell lung cancer. Eur J Nucl Med Mol Imaging 2015;42:956-976.
• Yip C, Goh V, Davies A, Gossage J, Mitchell-Hay R, Hynes O, Maisey N, Ross P, Gaya A, Landau DB, Cook GJR, Griffin N, Mason R. Assessment of sarcopenia and changes in body composition after neoadjuvant chemotherapy and associations with clinical outcomes in oe-sophageal cancer. Eur Radiol 2014:24(5):998-1005.
• Yip C, Cook GJ, Weeks A, Goh VJ. Imaging assessment of lung tumor angiogenesis: insights and innovations. Semin Respir Crit Care Med 2014:35:112-128.
• Yip C, Thomas C, Michaelidou A, James D, Lynn R, Lei M, Guerrero Urbano T. Co-registration of cone-beam CT and planning CT in head & neck IMRT dose estimation: a feasi-ble adaptive radiotherapy strategy. Br J Radiol 2014;87:20130532.
• Yip CSP, Landau D, Kozarski R, Ganeshan B, Thomas R, Michaelidou A, Goh V. Primary esophageal cancer: Heterogeneity as potential prognostic biomarker in patients treated with definitive chemotherapy and radiation therapy. Radiology 2014;270(1):141-148.
• Davnall F, Yip C, Ljungqvist G, Selmi M, Ng F, Sanghera B, Ganeshan B, Miles K, Cook G, Goh V. Assessment of tumor heterogeneity by texture analysis: an emerging imaging tool in clinical practice? Insights Imaging 2012;3(6):573-89.

Research Trials

  • Evaluation of the synergism between radiation and immunotherapy through characterisation of peripheral immune phenotypes (RADIUM)
  • Intratumoral PD-L1 expression and Tumour infiltrating lymphocyte density in Oesophageal cancer treated with Neoadjuvant chemoradiation (PLuTON)