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Clin Assoc Prof Sim Kheng Leng David

MBBS, MMed (Int Med), MRCP(UK)

Head ＆ Senior Consultant

National Heart Centre Singapore

Specialty: Cardiology

Clinical Interest: Heart Failure, Heart Transplant

Conditions Treated by this Doctor:
Cardiomyopathy, Coronary Artery Disease/Coronary Heart Disease, Diabetes Mellitus, Dyslipidema, Heart Failure, Hypertension, Hypertension.

Clinical Appointments

Head ＆ Senior Consultant Department of Cardiology National Heart Centre Singapore
Director of Heart Failure Programme National Heart Centre Singapore
Director of Clinical & Translational Research Office National Heart Centre Singapore
Senior Consultant SingHealth Duke-NUS Transplant Centre

Profile

Clinical Associate Professor David Sim is the Head and Senior Consultant with the Department of Cardiology, Director of the Heart Failure Programme and Director of Clinical Trials at the National Heart Centre Singapore (NHCS). He is also the Project Director for the Advanced Care Planning Programme in the National Heart Centre Singapore. He was the Deputy Head of Department of Cardiolgy at NHCS from 2022 to May 2023.

He is a Clinical Associate Professor at Duke-NUS Medical School, and an Honorary Visiting Consultant at Dover Park Hospice, Singapore. Clin Assoc Prof Sim received a Fellowship in Heart Failure/Heart Transplant at the Alfred Hospital, Melbourne, Australia, and is a Member of the Royal College of Physicians, UK. He is also an Advisor to the Shastin National Heart Centre of Mongolia.

Clin Assoc Prof Sim plays an active role in various research projects and clinical trials and is the National Leader for Singapore for a few key global pharmacological heart failure trials.

His clinical interest is in Heart Failure.

Education

Royal College of Physicians (UK) Diploma, 2004
Masters of Medicine (Internal Medicine), National University of Singapore, 2004
Bachelor of Medicine and Surgery, National University of Singapore, 2001

Professional Appointments and Committee Memberships

Head, Department of Cardiology, National Heart Centre Singapore, June 2023 to Present
Director, Clinical & Translational Research Office, National Heart Centre Singapore, May 2020 to Present
Director, Heart Failure Programme, National Heart Centre Singapore, 2011 to Present
Senior Consultant, Department of Cardiology, National Heart Centre Singapore, Present
Deputy Head, Department of Cardiology, National Heart Centre Singapore, January 2022 to 31 May 2023
Member, Paediatric Heart Transplant Committee, SingHealth, 2017 to Present
Deputy Director, Heart Failure Service Improvement, Ministry of Health, August 2018 to Present
Visiting Consultant, Dover Park Hospice, 2016 to Present
Senior Lecturer, Yong Loo Lin School of Medicine, 2012 to Present
International Honorary Advisor, Heart Failure Society (Hong Kong), 2021 to Present
President, Heart Failure Society (Singapore), 2018 to 2022
Immediate Past President, Heart Failure Society (Singapore), 2022 to 2024
Adjunct Assistant Professor, Duke-NUS Medical School, January 2012 to December 2018
Member of the Royal College of Physicians, UK since 2004

Awards

The Public Administration Medal (Bronze), Prime Minister's Office, 2023
Healthcare Humanity Award, Courage Fund, 2019
SingHealth Outstanding Clinician, 2018
SingHealth Residency Outstanding Faculty Award Academic Year 2015/2016
Health Services Development Programme Award 2011 (Ministry of Health Singapore): Ultrafiltration for Heart Failure (Project Director)
SingHealth Best Registrar Award 2008
SingHealth Health Manpower Development Plan Award 2008

Research Interests

Epidemiology of heart failure in Asia (Director of Heart Failure in charge of setting up the Heart Failure programme in National Heart Centre Singapore)
Pharmacological therapy for acute and chronic heart failure for reduced and preserved ejection fraction (Director of Heart Failure, National Heart Centre Singapore)
National Leader for Singapore for key global trials on pharmacological therapy for heart failure
Mechanical assist devices in advanced heart failure (Principal cardiologist involved in the mechanical assist device programme in National Heart Centre Singapore)
Advance care planning and end of life issue in heart failure (Director of the Advance Care Planning (ACP) programme in National Heart Centre and member of the ACP National steering committee)

Publications

Santhanakrishnan Rajalakshmi; Chong Jenny P C; Ng Tze P; Ling Lieng H;Sim David; Leong Kui Toh G; Yeo Poh Shuan D; Ong Hean Y; Jaufeerally Fazlur; Wong Raymond; Chai Ping; Low Adrian F; Richards Arthur Mark; Lam Carolyn S P Growth differentiation factor 15, ST2, high-sensitivity troponin T, and N-terminal pro brain natriuretic peptide in heart failure with preserved vs. reduced ejection fraction. European journal of heart failure 2012; 14(12):1338-47 (Article; Published in Print)
Zhong Liang; Ng Kenneth K C; Sim Ling Ling; Allen John Carson; Lau Yee How;Sim David K L; Lee Raymond K K; Poh Kian Keong; Chua Terrance S J; Kassab Ghassan S; Kwok Bernard W K; Tan Ru San Myocardial contractile dysfunction associated with increased 3-month and 1-year mortality in hospitalized patients with heart failure and preserved ejection fraction. International journal of cardiology 2013; 168(3):1975-83 (Article; Published in Print)
Lim Choon Pin;Sim David Kheng Leng Peripartum cardiomyopathy: experience in an Asian tertiary centre. Singapore medical journal 2013; 54(1):24-7 (Article; Published in Print)
Santhanakrishnan Rajalakshmi; Ng Tze P; Cameron Vicky A; Gamble Greg D; Ling Lieng H;Sim David; Leong Gerard Kui Toh; Yeo Poh Shuan Daniel; Ong Hean Yee; Jaufeerally Fazlur; Wong Raymond Ching-Chiew; Chai Ping; Low Adrian F; Lund Mayanna; Devlin Gerry; Troughton Richard; Richards A Mark; Doughty Robert N; Lam Carolyn S P The Singapore Heart Failure Outcomes and Phenotypes (SHOP) study and Prospective Evaluation of Outcome in Patients with Heart Failure with Preserved Left Ventricular Ejection Fraction (PEOPLE) study: rationale and design. Journal of cardiac failure 2013; 19(3):156-62 (Article; Published in Print)
Sim DK, Tan SH, Tan, BC, Neo CL, Wong G Advance care planning for patients with heart failure in a multi-ethnic South East Asian cohort British Medical Journal Support Palliative Care 2013; 3(2):257-258 (Article; Published in Print)
Lim Choon Pin; Sivathasan Cumaraswamy; Tan Teing Ee; Lim Chong Hee; Kerk Ka Lee; Sim David Kheng Leng Use of left ventricular assist device (HeartMate II): a Singapore experience. Artificial organs 2014; 38(7):543-8 (Article; Published in Print)
Go Yun Yun; Allen John Carson; Chia Shaw Yang; Sim Ling Ling; Jaufeerally Fazlur Rehman; Yap Jonathan; Ching Chi Keong;Sim David; Kwok Bernard; Liew Reginald Predictors of mortality in acute heart failure: interaction between diabetes and impaired left ventricular ejection fraction. European journal of heart failure 2014; 16(11):1183-9 (Article; Published in Print)
Koh Angela S M; Kok Tian Yue;Sim David K L; Lath Narayan; Tan Ru San Imaging cardiac sarcoidosis by cardiac positron emission tomography (PET): a local experience using a high-fat, low-to-no carbohydrate protocol. Annals of the Academy of Medicine, Singapore 2014; 43(7):383-5 (Article; Published in Print)
Yeo Tee Joo; Yeo Poh Shuan Daniel; Ching-Chiew Wong Raymond; Ong Hean Yee; Leong Kui Toh Gerard; Jaufeerally Fazlur;Sim David; Santhanakrishnan Rajalakshmi; Lim Shir Lynn; M Y Chan Michelle; Chai Ping; Low Adrian F; Ling Lieng H; Ng Tze Pin; Richards A Mark; Lam Carolyn S P Iron deficiency in a multi-ethnic Asian population with and without heart failure: prevalence, clinical correlates, functional significance and prognosis. European journal of heart failure 2014; 16(10):1125-32 (Article; Published in Print)
Chang P, Chia SY, Sim LL, Gao F, Lee FL, Chia P, Wong RC, Seow SC, Leong GK, Yeo PS,Sim D, Chua T, Kwok BW, Lam CS Impact of Sex On Clinical Characteristics And In Hospital Outcomes In A Multi- Ethnic Southeast Asian Population Of Patients Hospitalized For Acute Heart Failure Asean Heart Journal 2014; 22(1):42-47 (Article; Published in Print)
Hoong Caroline Wei Shan; Lim Choon Pin; Gao Fei; Chen Qifeng; Kawa Leslie Bahn; Ching Chi Keong;Sim David Kheng Leng Outcomes of heart failure with preserved ejection fraction in a Southeast Asian cohort. Journal of cardiovascular medicine (Hagerstown, Md.) 2015; 16(9):583-90 (Article; Published in Print)
Huang Fei Qiong; Tan Ru San;Sim David; Le Thu Thao; Zhong Liang Left ventricular diastolic function assessment using time differences between mitral annular velocities and transmitral inflow velocities in patients with heart failure. Heart, lung & circulation 2015; 24(3):257-63 (Article; Published in Print)
Yap Jonathan;Sim David; Lim Choon Pin; Chia Shaw Yang; Go Yun Yun; Jaufeerally Fazlur Rehman; Sim Ling Ling; Liew Reginald; Ching Chi-Keong Predictors of two-year mortality in Asian patients with heart failure and preserved ejection fraction. International journal of cardiology 2015; 183:33-8 (Article; Published in Print)
Wong Lee Lee; Armugam Arunmozhiarasi; Sepramaniam Sugunavathi; Karolina Dwi Setyowati; Lim Kai Ying; Lim Jia Yuen; Chong Jenny P C; Ng Jessica Y X; Chen Yei-Tsung; Chan Michelle M Y; Chen Zhaojin; Yeo Poh Shuan D; Ng Tze P; Ling Lieng H;Sim David; Leong Kui Toh G; Ong Hean Y; Jaufeerally Fazlur; Wong Raymond; Chai Ping; Low Adrian F; Lam Carolyn S P; Jeyaseelan Kandiah; Richards Arthur Mark Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction. European journal of heart failure 2015; 17(4):393-404 (Article; Published in Print)
Chan Michelle M Y; Santhanakrishnan Rajalakshmi; Chong Jenny P C; Chen Zhaojin; Tai Bee Choo; Liew Oi Wah; Ng Tze Pin; Ling Lieng H;Sim David; Leong Kui Toh G; Yeo Poh Shuan Daniel; Ong Hean-Yee; Jaufeerally Fazlur; Wong Raymond Ching-Chiew; Chai Ping; Low Adrian F; Richards Arthur M; Lam Carolyn S P Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction. European journal of heart failure 2016; 18(1):81-8 (Article; Published in Print)
Chetna Malhotra, Genevieve Cheng Sim Wong, Boon Cheng Tan, Clarice Shu Hwa Ng, Neo Chia Lee, Cindy Suck Lan Lau,David Kheng Leng Sim, Eric Andrew Finkelstein Living with heart failure: Perspectives of patients from Singapore Proceedings of Singapore Healthcare 2016; 25(2):92-97 (Article; Published in Print)
Teo Loon Yee Louis; Lim Choon Pin; Neo Chia Lee; Teo Lee Wah; Ng Swee Ling Elaine; Chan Laura Lihua; Kaushik Manish;Sim Kheng Leng David Ultrafiltration in patients with decompensated heart failure and diuretic resistance: an Asian centre's experience. Singapore medical journal 2016; 57(7):378-83 (Article; Published in Print)
Chan Laura Lihua; Lim Choon Pin; Aung Soe Tin; Quetua Paul; Ho Kah Leng; Chong Daniel; Teo Wee Siong; Sim David; Ching Chi Keong Patient barriers to implantable cardioverter defibrillator implantation for the primary prevention of sudden cardiac death in patients with heart failure and reduced ejection fraction. Singapore medical journal 2016; 57(4):182-7 (Article; Published in Print)
Ruan Wen; Lim Swee Han; Ding Zee Pin;Sim David Kl; Gao Fei; Gunasegaran Kurugulasigamoney; Kwok Bernard Wk; Tan Ru San Prevalence, Presentation, and Outcome of Heart Failure with Preserved Ejection Fraction among Patients Presenting with Undifferentiated Dyspnoea to the Emergency Room: A 10-year Analysis from a Tertiary Centre. Annals of the Academy of Medicine, Singapore 2016; 45(1):18-26 (Article; Published in Print)
Chetna Malhotra,David Kheng Leng Sim, Fazlur Jaufeerally, Nivedita Nakkarni Vikas, Genevieve Wong Cheng Sim, Boon Cheng Tan, Clarice Shu Hwa Ng, Pei Leng Tho, Jingfen Lim, Claire Ya Ting Chuang, Florence Hui Mei Fong, Joy Liu, Eric A Finkelstein Impact of advance care planning on the care of patients with heart failure: study protocol for a randomized controlled trial Trials 2016; NA(NA):NA-NA (Article; E-Published Only (Never in Print)/E-collection)
Gijsberts Crystel M; Benson Lina; Dahlström Ulf; Sim David; Yeo Daniel P S; Ong Hean Yee; Jaufeerally Fazlur; Leong Gerard K T; Ling Lieng H; Richards A Mark; de Kleijn Dominique P V; Lund Lars H; Lam Carolyn S P Ethnic differences in the association of QRS duration with ejection fraction and outcome in heart failure. Heart (British Cardiac Society) 2016; 102(18):1464-71 (Article; Published in Print)
Chan LL, Lim CP, LIm CH, Tan TE,Sim D, Sivathasan C Novel Use of Thalidomide in Recurrent Gastrointestinal Tract Bleeding in Patients with Left Ventricular Assist Devices: A Case Series Heart Lung Circulation 2016; NA:NA-NA (Article; E-Published Ahead of Print)
Gohar Aisha; Chong Jenny P C; Liew Oi Wah; den Ruijter Hester; de Kleijn Dominique P V; Sim David; Yeo Daniel P S; Ong Hean Yee; Jaufeerally Fazlur; Leong Gerard K T; Ling Lieng H; Lam Carolyn S P; Richards A Mark The prognostic value of highly sensitive cardiac troponin assays for adverse events in men and women with stable heart failure and a preserved vs. reduced ejection fraction. European journal of heart failure 2017; 19(12):1638-1647 (Article; E-Published Only (Never in Print)/E-collection)
Schafer Sebastian; de Marvao Antonio; Adami Eleonora; Fiedler Lorna R; Ng Benjamin; Khin Ester; Rackham Owen J L; van Heesch Sebastiaan; Pua Chee J; Kui Miao; Walsh Roddy; Tayal Upasana; Prasad Sanjay K; Dawes Timothy J W; Ko Nicole S J;Sim David; Chan Laura L H; Chin Calvin W L; Mazzarotto Francesco; Barton Paul J; Kreuchwig Franziska; de Kleijn Dominique P V; Totman Teresa; Biffi Carlo; Tee Nicole; Rueckert Daniel; Schneider Valentin; Faber Allison; Regitz-Zagrosek Vera; Seidman Jonathan G; Seidman Christine E; Linke Wolfgang A; Kovalik Jean-Paul; O'Regan Declan; Ware James S; Hubner Norbert; Cook Stuart A Titin-truncating variants affect heart function in disease cohorts and the general population. Nature genetics 2017; 49(1):46-53 (Article; Published in Print)
Sivathasan Cumaraswamy; Lim Choon Pin; Kerk Ka Lee; Sim David K L; Mehra Mandeep R Mechanical circulatory support and heart transplantation in the Asia Pacific region. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2017; 36(1):13-18 (Article; Published in Print)
Bank Ingrid E M; Gijsberts Crystel M; Teng Tiew-Hwa K; Benson Lina;Sim David; Yeo Poh Shuan Daniel; Ong Hean Yee; Jaufeerally Fazlur; Leong Gerard K T; Ling Lieng H; Richards A Mark; de Kleijn Dominique P V; Dahlström Ulf; Lund Lars H; Lam Carolyn S P Prevalence and Clinical Significance of Diabetes in Asian Versus White Patients With Heart Failure. JACC. Heart failure 2017; 5(1):14-24 (Article; Published in Print)
Cowie Martin R; Lopatin Yuri M; Saldarriaga Clara; Fonseca Cândida;Sim David; Magaña Jose Antonio; Albuquerque Denilson; Trivi Marcelo; Moncada Gustavo; González Castillo Baldomero A; Sánchez Mario Osvaldo Speranza; Chung Edward The Optimize Heart Failure Care Program: Initial lessons from global implementation. International journal of cardiology 2017; 236:340-344 (Article; Published in Print)
Drum Cl, Tan WKY, Chan SP, Pakkiri LS, Chong JPC, Liew OW, Ng TP, Ling LH,Sim D, Leong KG, Yeo DPS, Ong HY, Jaufeerally F, Wong RCC, Chai P, Low AF, Davidsson P, Liljeblad M, Soderling AS, Gan LM, Bhat RV, Purnamawati K, Lam CSP, Richards AM Thymosin Beta 4 is Elevated in Women with Heart Failure with Preserved Ejection Fraction Journal of American Heart Association 2017; 6(6):NA-NA (Article; E-Published Only (Never in Print)/E-collection)
Bosch L, Lam CSP, Gong L, Chan SP,Sim D, Yeo D, Jaufeerally F, Leong KTG, Ong HY, Ng TP, Richards AM, Arslan F, Ling LH Right ventricular dysfunction in left sided heart failure with preserved versus reduced ejection fraction European Journal of Heart Failure 2017; NA:NA-NA (Article; E-Published Ahead of Print)
Seng BJJ, Teo LLY, Chan LL, Sim DKL, Kerk KL, Soon JL, Tan TE, Sivathasan C, Lim CP Novel use of low dose thalidomide in refractory gastrointestinal bleeding in left ventricular assist device patients International Journal of Artificial Organs 2017 (Article; E-Published Ahead of Print)
Go YY, Sugimoto T, Bulluck H, Acharyya S, Allen JC, Chia SY, Jaufeerally,SIm D, Lim TK, Liew R, Lam CSP Age and ejection fraction modify the impact of atrial fibrillation on acute heart failure outocmes European Journal Heart Failure 2017 (Article; E-Published Ahead of Print)
Liang Lin; Bin-Chia Wu David; Aziz Mohamed Ismail Abdul; Wong Raymond; Sim David; Leong Kui Toh Gerard; Wei Yong Quek; Tan Doreen; Ng Kwong Cost-effectiveness of sacubitril/valsartan versus enalapril in patients with heart failure and reduced ejection fraction. Journal of medical economics 2018; 21(2):174-181 (Article; Published in Print)
Yun Yun Go, Reinhard Sellmair , John C Allen Jr , Anders Sahlén , Heerajnarain Bulluck , David Sim , Fazlur R Jaufeerally, Michael R MacDonald , Zhan Yun Lim , Ping Chai , Seet Yoong Loh , Jonathan Yap , Carolyn S P Lam Defining a 'frequent admitter' phenotype among patients with repeat heart failure admissions Eur J Heart Fail 2019 Mar;21(3):311-318. doi: 10.1002/ejhf.1348. Epub 2018 Dec 13.
Chetna Malhotra, Renette Foo, Ratna Singh, Semra Ozdemir, Irene Teo , David Sim, Fazlur Jaufeerally, Than Aung , Yeo Khung Keong , Nivedita Nadkarni , Eric Andrew Finkelstein Study protocol for a cohort study of patients with advanced heart failure in Singapore BMJ Open 2018 Sep 17;8(9):e022248. doi: 10.1136/bmjopen-2018-022248.
Jasper Tromp, Arthur Mark Richards, Wan Ting Tay, Tiew-Hwa K Teng , Poh Shuan Daniel Yeo , David Sim , Fazlur Jaufeerally , Gerard Leong , Hean Yee Ong , Lieng Hsi Ling , Dirk J van Veldhuisen, Tiny Jaarsma, Adriaan A Voors, Peter van der Meer, Rudolf A de Boer, Carolyn S P Lam N-terminal pro-B-type natriuretic peptide and prognosis in Caucasian vs. Asian patients with heart failure ESC Heart Fail 2018 Apr;5(2):279-287. doi: 10.1002/ehf2.12252. Epub 2018 Jan 30.
Shuang Leng, Xulei Yang, Xiaodan Zhao, Zeng Zeng, Yi Su, Angela S Koh, David Sim, Ju Le Tan, Ru San Tan, Liang Zhong Computational Platform Based on Deep Learning for Segmenting Ventricular Endocardium in Long-axis Cardiac MR Imaging Annu Int Conf IEEE Eng Med Biol Soc 2018 Jul;2018:4500-4503. doi: 10.1109/EMBC.2018.8513140.
Chetna Malhotra, David Sim, Fazlur Jaufeerally, Eric A Finkelstein Associations between understanding of current treatment intent, communication with healthcare providers, preferences for invasive life-sustaining interventions and decisional conflict: results from a survey of patients with advanced heart failure in Singapore BMJ Open 2018 Sep 19;8(9):e021688. doi: 10.1136/bmjopen-2018-021688.
Chun Yuan Khoo, John Carson Allen , Shaw Yang Chia, Laura Lihua Chan, Choon Pin Lim, David Sim, Chi Keong Ching Mortality outcome and predictive risk factors for death in patients with heart failure and reduced ejection fraction who declined implantable cardioverter defibrillator implantation in Singapore J Arrhythm 2018 Aug 18;34(5):536-540. doi: 10.1002/joa3.12106. eCollection 2018 Oct.
Scott D Solomon , Adel R Rizkala , Martin P Lefkowitz , Victor C Shi , JianJian Gong , Nagesh Anavekar , Stefan D Anker 5, Juan L Arango , Jose L Arenas , Dan Atar , Turia Ben-Gal , Sergey A Boytsov , Chen-Huan Chen , Vijay K Chopra , John Cleland, Josep Comin-Colet , Hans-Dirk Duengen , Luis E Echeverría Correa , Gerasimos Filippatos , Andreas J Flammer , Michel Galinier , Armando Godoy, Eva Goncalvesova , Stefan Janssens , Tzvetana Katova , Lars Køber , Małgorzata Lelonek , Gerard Linssen , Lars H Lund , Eileen O'Meara , Béla Merkely , Davor Milicic , Byung-Hee Oh , Sergio V Perrone , Naresh Ranjith , Yoshihiko Saito , Jose F Saraiva , Sanjiv Shah , Petar M Seferovic , Michele Senni , Antonio S Sibulo Jr , David Sim , Nancy K Sweitzer , Jyrki Taurio , Dragos Vinereanu , Bojan Vrtovec , Jiří Widimský Jr , Mehmet B Yilmaz , Jingmin Zhou , Robert Zweiker , Inder S Anand , Junbo Ge , Carolyn S P Lam , Aldo P Maggioni , Felipe Martinez , Milton Packer , Marc A Pfeffer , Burkert Pieske , Margaret M Redfield , Jean L Rouleau , Dirk J Van Veldhuisen , Faiez Zannad , Michael R Zile , John J V McMurray Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial Circ Heart Fail 2018 Jul;11(7):e004962. doi: 10.1161/CIRCHEARTFAILURE.118.004962.
Stefan D Anker , Javed Butler, Gerasimos S Filippatos, Waheed Jamal, Afshin Salsali, Janet Schnee, Karen Kimura, Cordula Zeller, Jyothis George, Martina Brueckmann , Faiez Zannad, Milton Packer, EMPEROR-Preserved Trial Committees and Investigators Evaluation of the effects of sodium-glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR-Preserved Trial Eur J Heart Fail 2019 Oct;21(10):1279-1287. doi: 10.1002/ejhf.1596. Epub 2019 Sep 16.
Piotr Ponikowski , Bridget-Anne Kirwan, Stefan D Anker , Maria Dorobantu, Jarosław Drozdz , Vincent Fabien , Gerasimos Filippatos , Teba Haboubi , Andre Keren , Irakli Khintibidze , Hans Kragten , Felipe A Martinez, Theresa McDonagh , Marco Metra, Davor Milicic, José C Nicolau , Marcus Ohlsson, Alexander Parhomenko , Domingo A Pascual-Figal , Frank Ruschitzka, David Sim, Hadi Skouri, Peter van der Meer, Ewa A Jankowska Rationale and design of the AFFIRM-AHF trial: a randomised, double-blind, placebo-controlled trial comparing the effect of intravenous ferric carboxymaltose on hospitalisations and mortality in iron-deficient patients admitted for acute heart failure Eur J Heart Fail 2019 Dec;21(12):1651-1658. doi: 10.1002/ejhf.1710. Epub 2019 Dec 28.
Burkert Pieske, Mahesh J Patel , Cynthia M Westerhout , Kevin J Anstrom , Javed Butler, Justin Ezekowitz, Adrian F Hernandez, Joerg Koglin, Carolyn S P Lam, Piotr Ponikowski, Lothar Roessig , Adriaan A Voors, Christopher M O'Connor, Paul W Armstrong , VICTORIA Study Group Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial Eur J Heart Fail 2019 Dec;21(12):1596-1604. doi: 10.1002/ejhf.1664. Epub 2019 Dec 9.
João Pedro Ferreira, Sarah Kraus , Sharon Mitchelle, Pablo Perel , Daniel Piñeiro , Ovidiu Chioncel , Roberto Colque , Rudolf A de Boer , Juan Esteban Gomez-Mesa, Hugo Grancelli, Carolyn S P Lam, Antoni Martinez-Rubio, John J V McMurray, Alexandre Mebazaa, Gurusher Panjrath, Ileana L Piña, Mahmoud Sani, David Sim, Mary Walsh, Clyde Yancy, Faiez Zannad, Karen Sliwa World Heart Federation Roadmap for Heart Failure Glob Heart 2019 Sep;14(3):197-214. doi: 10.1016/j.gheart.2019.07.004.
Samer Kabbani , Waleed Al Habeeb , Houng-Bang Liew , Jagdish C Mohan , Elijah Ogola , David Sim , Nqoba Tsabedze Supporting the Management of Patients with Heart Failure within Asia-Pacific, Middle East, and African Countries: A Toolbox for Healthcare Providers Cardiology 2019;142 Suppl 1:1-10. doi: 10.1159/000496663. Epub 2019 Apr 4.
YanHong Dong, Shuan Yong Teo , Kathleen Kang , Melissa Tan , Lieng Hsi Ling , Poh Shuan Daniel Yeo, David Sim, Fazlur Jaufeerally , Kui Toh Gerard Leong , Hean Yee Ong , Dinna Soon, Sheldon Lee, Seet Yoong Loh , Ru San Tan , Siew Pang Chan , Arthur Mark Richards , Carolyn Su Ping Lam Cognitive impairment in Asian patients with heart failure: prevalence, biomarkers, clinical correlates, and outcomes Eur J Heart Fail 2019 May;21(5):688-690. doi: 10.1002/ejhf.1442. Epub 2019 Apr 2.
Eugene S J Tan , Wan Ting Tay , Tiew-Hwa Katherine Teng , David Sim , Kui Toh Gerard Leong , Poh Shuan Daniel Yeo , Hean Yee Ong , Fazlur Jaufeerally , Tze Pin Ng , Katrina Poppe , Mayanna Lund, Gerard Devlin, Richard W Troughton , Lieng Hsi Ling, Arthur Mark Richards, Robert N Doughty, Carolyn S P Lam Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific Heart 2019 Jun;105(11):842-847. doi: 10.1136/heartjnl-2018-314077. Epub 2019 Jan 19.
Lee Lee Wong , Ruiyang Zou , Lihan Zhou , Jia Yuen Lim , Dominic C Y Phua , Chengcheng Liu , Jenny P C Chong , Jessica Y X Ng , Oi Wah Liew , Siew Pang Chan , Yei-Tsung Chen , Michelle M Y Chan , Poh Shuan D Yeo , Tze Pin Ng , Lieng H Ling , David Sim , Kui Toh G Leong , Hean Y Ong , Fazlur Jaufeerally , Raymond Wong , Ping Chai , Adrian F Low , Mayanna Lund , Gerry Devlin , Richard Troughton , Vicky A Cameron , Robert N Doughty , Carolyn S P Lam , Heng Phon Too , Arthur Mark Richards Combining Circulating MicroRNA and NT-proBNP to Detect and Categorize Heart Failure Subtypes J Am Coll Cardiol 2019 Mar 26;73(11):1300-1313. doi: 10.1016/j.jacc.2018.11.060.
Eugene Sj Tan, Siew Pang Chan, Chang Fen Xu, Jonathan Yap, Arthur Mark Richards, Lieng Hsi Ling , David Sim , Fazlur Jaufeerally , Daniel Yeo , Seet Yoong Loh , Hean Yee Ong , Kui Toh Gerard Leong , Tze Pin Ng , Shwe Zin Nyunt , Liang Feng , Peter Okin, Carolyn Sp Lam , Toon Wei Lim Cornell product is an ECG marker of heart failure with preserved ejection fraction Heart Asia 2019 May 28;11(1):e011108. doi: 10.1136/heartasia-2018-011108. eCollection 2019.
Jonathan Yap , Shaw Yang Chia, Fang Yi Lim, John C Allen, Louis Teo, David Sim, Yun Yun Go, Fazlur Rehman Jaufeerally, Matthew Seow, Bernard Kwok, Reginald Liew, Carolyn Sp Lam, Chi Keong Ching The Singapore Heart Failure Risk Score: Prediction of Survival in Southeast Asian Patients Ann Acad Med Singap 2019 Mar;48(3):86-94.
Jonathan Yap , Fang Yi Lim , Shaw Yang Chia , John Carson Allen Jr , Fazlur Rehman Jaufeerally , Michael Ross Macdonald , Ping Chai , Seet Yoong Loh , Patrick Lim , Ma Wai Wai Zaw , Louis Teo , David Sim , Carolyn S P Lam . Prediction of Survival in Asian Patients Hospitalized With Heart Failure: Validation of the OPTIMIZE-HF Risk Score J Card Fail 2019 Jul;25(7):571-575. doi: 10.1016/j.cardfail.2019.02.016. Epub 2019 Feb 26
Yii Ean Teh , Choon Pin Lim , Louis Loon Yee Teo , Jia Lin Soon , Victor Tar Toong Chao , Chia Lee Neo , Joycelyn Li Li Tan , Ka Lee Kerk , David Kheng Leng Sim , Teing Ee Tan , Ban Hock Tan , Sivathasan Cumaraswamy , Thuan Tong Tan Staphylococcal driveline infections are the predominant type of left ventricular assist device associated infections in Singapore Infect Dis (Lond) 2019 Jun;51(6):417-424. doi: 10.1080/23744235.2019.1592216. Epub 2019 Apr 15.
Chetna Malhotra, Meibo Hu, Rahul Malhotra , David Sim, Fazlur Rehman Jaufeerally , Filipinas G Bundoc , Eric A Finkelstein Instability in End-of-Life Care Preference Among Heart Failure Patients: Secondary Analysis of a Randomized Controlled Trial in Singapore J Gen Intern Med 2020 Jul;35(7):2010-2016. doi: 10.1007/s11606-020-05740-2. Epub 2020 Feb 26.
Shirlyn Hui-Shan Neo , Jasmine Si Min Ku , Genevieve Cheng Sim Wong , Boon Cheng Tan , Eugene Yong Wei Tan, Jasmine Yun Ting Tan , Ka Lee Kerk , David Kheng Leng Sim, Cumaraswamy Sivathasan, Sungwon Yoon Life Beyond Heart Failure-What Are the Long-Term Challenges, Supportive Care Needs, and Views Toward Supportive Care of Multiethnic Asian Patients With Left Ventricular Assist Device and Their Caregivers? J Pain Symptom Manage 2020 Sep;60(3):577-587.e1. doi: 10.1016/j.jpainsymman.2020.03.022. Epub 2020 Apr 3.
Chetna Malhotra , David Sim , Fazlur Rehman Jaufeerally , Meibo Hu , Nivedita Nadkarni , Clarice Shu Hwa Ng , Genevieve Wong , Boon Cheng Tan , Jing Fen Lim , Claire Ya-Ting Chuang , Eric A Finkelstein Impact of a Formal Advance Care Planning Program on End-of-Life Care for Patients With Heart Failure: Results From a Randomized Controlled Trial J Card Fail 2020 Jul;26(7):594-598. doi: 10.1016/j.cardfail.2020.01.015. Epub 2020 Jan 25.
Piotr Ponikowski , Bridget-Anne Kirwan , Stefan D Anker , Theresa McDonagh , Maria Dorobantu , Jarosław Drozdz , Vincent Fabien , Gerasimos Filippatos , Udo Michael Göhring , Andre Keren , Irakli Khintibidze , Hans Kragten , Felipe A Martinez , Marco Metra , Davor Milicic , José C Nicolau , Marcus Ohlsson , Alexander Parkhomenko , Domingo A Pascual-Figal , Frank Ruschitzka , David Sim , Hadi Skouri , Peter van der Meer , Basil S Lewis , Josep Comin-Colet , Stephan von Haehling , Alain Cohen-Solal , Nicolas Danchin , Wolfram Doehner , Henry J Dargie , Michael Motro , Javed Butler , Tim Friede , Klaus H Jensen , Stuart Pocock , Ewa A Jankowska , AFFIRM-AHF investigators Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial Lancet 2020 Dec 12;396(10266):1895-1904. doi: 10.1016/S0140-6736(20)32339-4. Epub 2020 Nov 13.
Stefan D Anker, Javed Butler , Gerasimos Filippatos , Muhammad Shahzeb Khan , João Pedro Ferreira , Edimar Bocchi , Michael Böhm , Hans Pieter Brunner-La Rocca , Dong-Ju Choi , Vijay Chopra , Eduardo Chuquiure , Nadia Giannetti , Juan Esteban Gomez-Mesa , Stefan Janssens , James L Januzzi , Jose R Gonzalez-Juanatey , Bela Merkely , Stephen J Nicholls , Sergio V Perrone , Ileana L Piña , Piotr Ponikowski , Michele Senni , Marie-France Seronde , David Sim , Jindrich Spinar , Iain Squire , Stefano Taddei , Hiroyuki Tsutsui , Subodh Verma, Dragos Vinereanu , Jian Zhang , Waheed Jamal , Sven Schnaidt , Janet M Schnee , Martina Brueckmann , Stuart J Pocock , Faiez Zannad , Milton Packer , EMPEROR-Preserved Trial Committees and Investigators Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR-Preserved trial Eur J Heart Fail 2020 Dec;22(12):2383-2392. doi: 10.1002/ejhf.2064.
Francesco Mazzarotto , Upasana Tayal , Rachel J Buchan , William Midwinter , Alicja Wilk , Nicola Whiffin , Risha Govind , Erica Mazaika , Antonio de Marvao , Timothy J W Dawes , Leanne E Felkin , Mian Ahmad , Pantazis I Theotokis , Elizabeth Edwards , Alexander Y Ing , Kate L Thomson , Laura L H Chan 9, David Sim 9, A John Baksi 1 2, Antonis Pantazis 2, Angharad M Roberts 1 2, Hugh Watkins , Birgit Funke, Declan P O'Regan 5, Iacopo Olivotto , Paul J R Barton , Sanjay K Prasad, Stuart A Cook, James S Ware, Roddy Walsh Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy Circulation 2020 Feb 4;141(5):387-398. doi: 10.1161/CIRCULATIONAHA.119.037661. Epub 2020 Jan 27.
Ek Khoon Tan , Ye Xin Koh , Terence Kee , Juhainah Binte Juhari , Teing Ee Tan , David Kheng Leng Sim , Aloysius Yew Leng Ho , Lalitha Krishnan , Ping Sing Tee , Thinesh Lee Krishnamoorthy 2, Brian Kim Poh Goh , Ban Hock Tan , Shimin Jasmine Chung , Ghee Chee Phua , Prema Raj Jeyaraj Waitlisted Transplant Candidates' Attitudes and Concerns Toward Transplantation During COVID-19 Ann Transplant 2020 Dec 8;25:e926992. doi: 10.12659/AOT.926992.
Wouter Ouwerkerk 1 2, Jasper Tromp , Xuanyi Jin , Fazlur Jaufeerally , Poh Shuan Daniel Yeo , Kui Toh Gerard Leong , Hean Yee Ong , Lieng Hsi Ling , Seet Yoong Loh , David Sim , Sheldon Lee , Dinna Soon , Calvin Chin , A Mark Richards , Carolyn S P Lam Heart failure with preserved ejection fraction diagnostic scores in an Asian population4 Eur J Heart Fail 2020 Sep;22(9):1737-1739. doi: 10.1002/ejhf.1851. Epub 2020 May 6.
Shir Lynn Lim , Mihir Gandhi , Kai Lee Woo , Horng Ruey Chua , Yoke Ching Lim , David K L Sim , Sheldon S G Lee , Yee Leong Teoh , Arthur Mark Richards , Carolyn S P Lam Nitrates in combination with hydralazine in cardiorenal syndrome: a randomized controlled proof-of-concept study ESC Heart Fail 2020 Nov 4;7(6):4267-4276. doi: 10.1002/ehf2.13076. Online ahead of print.
Gillian Stein , Tiew-Hwa K Teng , Wan T Tay , A Mark Richards , Robert Doughty , YanHong Dong , David Sim , Poh S D Yeo , Fazlur Jaufeerally , Gerard Leong , Dinna Soon , Lieng H Ling , Carolyn S P Lam Ethnic differences in quality of life and its association with survival in patients with heart failure Clin Cardiol 2020 Sep;43(9):976-985. doi: 10.1002/clc.23394. Epub 2020 Jun 20.
Semra Ozdemir , Irene Teo , Filipinas Gines Bundoc , Chetna Malhotra , Khung Keong Yeo , Kheng Leng David Sim , Eric Andrew Finkelstein Role in decision making among congestive heart failure patients and its association with patient outcomes: a baseline analysis of the SCOPAH study Patient Educ Couns 2021 Mar;104(3):496-504. doi: 10.1016/j.pec.2020.08.033. Epub 2020 Aug 29.
Chetna Malhotra , Filipinas G Bundoc , David Sim , Fazlur Rehman Jaufeerally , Eric A Finkelstein Instability in Preference for Place of Death Among Patients With Symptoms of Advanced Heart Failure J Am Med Dir Assoc 2021 Feb;22(2):349.e29-349.e34. doi: 10.1016/j.jamda.2020.05.030. Epub 2020 Jul 18.
Jonathan Yap , Yann Shan Keh , Tong Shen , Carolyn S P Lam , Shaw Yang Chia , Fazlur Rehman Jaufeerally , Wilson Ong , David Sim , Chi-Keong Ching QRS duration and cardiovascular mortality in Asian patients with heart failure and preserved and reduced ejection fraction Cardiol J 2021;28(1):166-169. doi: 10.5603/CJ.a2020.0041. Epub 2020 Mar 24.
Chetna Malhotra , Filipinas Bundoc , Felicia Jia Ler Ang , Semra Ozdemir , Irene Teo , David Sim , Fazlur Rehman Jaufeerally , Than Aung , Eric Finkelstein Financial difficulties and patient-reported outcomes among patients with advanced heart failure Qual Life Res 2021 May;30(5):1379-1387. doi: 10.1007/s11136-020-02736-7. Epub 2021 Apr 9.
Natalie Koh , Vera Jin-Ling Goh , Chee Kiang Teoh , Jin Shing Hon , Louis Loon Yee Teo , Choon Pin Lim , David Sim Angiotensin receptor-neprilysin inhibitor improves New York Heart Association class and N-terminal-pro B-type natriuretic peptide levels: initial experience in a Singapore single-centre cohort Singapore Med J 2021 Jul;62(7):359-361. doi: 10.11622/smedj.2021092.
Sarah Fitzsimons , Tee Joo Yeo , Lieng H Ling , David Sim , Kui Toh Gerard Leong , Poh Shuan Daniel Yeo , Hean Yee Ong , Fazlur Jaufeerally , Tze P Ng , Katrina Poppe , Mayanna Lund , Gerry Devlin , Richard Troughton , Carolyn S P Lam , A Mark Richards , Robert N Doughty Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype ESC Heart Fail 2021 Dec;8(6):4572-4583. doi: 10.1002/ehf2.13617. Epub 2021 Sep 30.
Jamie J Lo , Sungwon Yoon , Shirlyn Hui Shan Neo , David Kheng Leng Sim , Nicholas Graves Factors Influencing Potentially Futile Treatments at the End of Life in a Multiethnic Asian Cardiology Setting: A Qualitative Study Am J Hosp Palliat Care 2021 Dec 8;10499091211053624. doi: 10.1177/10499091211053624. Online ahead of print.
Eugene S J Tan , Siew-Pang Chan 1, Oi-Wah Liew , Jenny P C Chong , Gerard K T Leong , Daniel P S Yeo , Hean-Yee Ong , Fazlur Jaufeerally , Jonathan Yap , David Sim , Tze-Pin Ng , Lieng-Hsi Ling , Carolyn S P Lam , Arthur M Richards Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure Clin Chem 2021 Jan 8;67(1):216-226. doi: 10.1093/clinchem/hvaa287.
Jasper Tromp , Jennifer A Bryant , Xuanyi Jin 1, Gijs van Woerden , Salma Asali , Han Yiying , Oi Wah Liew , Jenny Chong Pek Ching , Fazlur Jaufeerally , Seet Yoong Loh , David Sim , Sheldon Lee , Dinna Soon , Wan Ting Tay , Milton Packer , Dirk J van Veldhuisen , Calvin Chin , A Mark Richards , Carolyn S P Lam 1 Epicardial fat in heart failure with reduced versus preserved ejection fraction Eur J Heart Fail 2021 May;23(5):835-838. doi: 10.1002/ejhf.2156. Epub 2021 Mar 30.
Jack Wei Chieh Tan , David Sim , Junya Ako , Wael Almahmeed , Mark E Cooper , Jamshed J Dalal , Chaicharn Deerochanawong , David Wei Chun Huang , Sofian Johar , Upendra Kaul , Sin Gon Kim , Natalie Koh , Alice Pik-Shan Kong , Rungroj Krittayaphong , Bernard Kwok , Bien J Matawaran , Quang Ngoc Nguyen , Loke Meng Ong , Jin Joo Park , Yongde Peng , David Kl Quek , Ketut Suastika , Norlela Sukor , Boon Wee Teo , Chee Kiang Teoh , Jian Zhang , Eugenio B Reyes , Su Yen Goh Consensus Recommendations by the Asian Pacific Society of Cardiology: Optimising Cardiovascular Outcomes in Patients with Type 2 Diabetes Eur Cardiol 2021 Apr 19;16:e14. doi: 10.15420/ecr.2020.52. eCollection 2021 Feb.
Khung Keong Yeo , Jack Wei Chieh Tan , David Wm Muller , Darren L Walters , JoAnn Lindenfeld , Michael Kang Yin Lee , Angus Shing Fung Chui , Sai Satish , Teguh Santoso , Shunsuke Kubo , John Chan Kok Meng , Kenny Yk Sin , See Hooi Ewe , David Sim , Edgar Tay , Krissada Meemook , Shih-Hsien Sung , Quang Ngoc Nguyen , Xiangbin Pan , Makoto Amaki , Masaki Izumo , Kentaro Hayashida , Jung Sun Kim , Do-Yoon Kang , Gregg Stone , Takashi Matsumoto Asian Pacific Society of Cardiology Consensus Recommendations on the Use of MitraClip for Mitral Regurgitation Eur Cardiol 2021 Jun 1;16:e25. doi: 10.15420/ecr.2021.01. eCollection 2021 Feb.
Ewa A Jankowska , Bridget-Anne Kirwan , Mikhail Kosiborod , Javed Butler , Stefan D Anker , Theresa McDonagh , Maria Dorobantu , Jarosław Drozdz , Gerasimos Filippatos , Andre Keren , Irakli Khintibidze , Hans Kragten , Felipe A Martinez , Marco Metra , Davor Milicic , José C Nicolau , Marcus Ohlsson , Alexander Parkhomenko , Domingo A Pascual-Figal , Frank Ruschitzka , David Sim , Hadi Skouri , Peter van der Meer , Basil S Lewis , Josep Comin-Colet , Stephan von Haehling , Alain Cohen-Solal , Nicolas Danchin , Wolfram Doehner , Henry J Dargie , Michael Motro , Tim Friede , Vincent Fabien , Fabio Dorigotti , Stuart Pocock , Piotr Ponikowski The effect of intravenous ferric carboxymaltose on health-related quality of life in iron-deficient patients with acute heart failure: the results of the AFFIRM-AHF study Eur Heart J 2021 Jun 3;42(31):3011-3020. doi: 10.1093/eurheartj/ehab234. Online ahead of print.
Carolyn S P Lam , João Pedro Ferreira , Egon Pfarr , David Sim , Hiroyuki Tsutsui , Stefan D Anker , Javed Butler , Gerasimos Filippatos , Stuart J Pocock , Naveed Sattar , Subodh Verma , Martina Brueckmann , Janet Schnee , Daniel Cotton , Faiez Zannad , Milton Packer Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial Eur Heart J 2021 Nov 14;42(43):4442-4451. doi: 10.1093/eurheartj/ehab360.
Marc A Pfeffer , Brian Claggett , Eldrin F Lewis , Christopher B Granger , Lars Køber , Aldo P Maggioni , Douglas L Mann , John J V McMurray , Jean-Lucien Rouleau , Scott D Solomon , Philippe G Steg , Otavio Berwanger , Maja Cikes , Carmine G De Pasquale , Cara East , Alberto Fernandez , Karola Jering , Ulf Landmesser , Roxana Mehran , Béla Merkely , Freny Vaghaiwalla Mody , Mark C Petrie , Ivo Petrov , Morten Schou , Michele Senni , David Sim , Peter van der Meer , Martin Lefkowitz , Yinong Zhou , Jianjian Gong , Eugene Braunwald , PARADISE-MI Investigators and Committees Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction N Engl J Med 2021 Nov 11;385(20):1845-1855. doi: 10.1056/NEJMoa2104508
Stefan D Anker , Javed Butler , Gerasimos Filippatos , João P Ferreira , Edimar Bocchi , Michael Böhm , Hans-Peter Brunner-La Rocca , Dong-Ju Choi , Vijay Chopra , Eduardo Chuquiure-Valenzuela , Nadia Giannetti , Juan Esteban Gomez-Mesa , Stefan Janssens , James L Januzzi , Jose R Gonzalez-Juanatey , Bela Merkely , Stephen J Nicholls , Sergio V Perrone , Ileana L Piña , Piotr Ponikowski , Michele Senni , David Sim , Jindrich Spinar , Iain Squire , Stefano Taddei , Hiroyuki Tsutsui , Subodh Verma , Dragos Vinereanu , Jian Zhang , Peter Carson , Carolyn Su Ping Lam , Nikolaus Marx , Cordula Zeller , Naveed Sattar , Waheed Jamal , Sven Schnaidt , Janet M Schnee , Martina Brueckmann , Stuart J Pocock , Faiez Zannad , Milton Packer , EMPEROR-Preserved Trial Investigators Empagliflozin in Heart Failure with a Preserved Ejection Fraction N Engl J Med 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27.
Jasper Tromp , Paul J Seekings , Chung-Lieh Hung , Mathias Bøtcher Iversen , Matthew James Frost , Wouter Ouwerkerk , Zhubo Jiang , Frank Eisenhaber , Rick S M Goh , Heng Zhao , Weimin Huang , Lieng-Hsi Ling , David Sim , Patrick Cozzone , A Mark Richards , Hwee Kuan Lee , Scott D Solomon , Carolyn S P Lam , Justin A Ezekowitz Automated interpretation of systolic and diastolic function on the echocardiogram: a multicohort study Lancet Digit Health 2022 Jan;4(1):e46-e54. doi: 10.1016/S2589-7500(21)00235-1. Epub 2021 Dec 1
Marc A Pfeffer , Brian Claggett , Eldrin F Lewis , Christopher B Granger , Lars Køber , Aldo P Maggioni , Douglas L Mann , John J V McMurray , Jean-Lucien Rouleau , Scott D Solomon , Philippe Gabriel Steg , Otavio Berwanger , Maja Cikes , Carmine G De Pasquale , Alberto Fernandez , Gerasimos Filippatos , Karola Jering , Ulf Landmesser , Venugopal Menon , Béla Merkely , Mark C Petrie , Ivo Petrov , Morten Schou , Michele Senni , David Sim , Peter van der Meer , Martin Lefkowitz , Yinong Zhou , Yi Wang , Eugene Braunwald Impact of Sacubitril/Valsartan Versus Ramipril on Total Heart Failure Events in the PARADISE-MI Trial Circulation 2022 Jan 4;145(1):87-89. doi: 10.1161/CIRCULATIONAHA.121.057429. Epub 2021 Nov 19.
Tay JCK, Chia SY, Sim DKL, Chai P, Loh SY, Shum AKL, Lee SSG, Lim PZY, Yap J. Interaction of Sex and Diabetes in Asian Patients with Heart Failure with Mildly Reduced Left Ventricular Ejection Fraction Ann Acad Med Singap. 2022 Aug;51(8):473-482. doi: 10.47102/annals-acadmedsg.2022113.
Jin X, Hung CL, Tay WT, Soon D, Sim D, Sung KT, Loh SY, Lee S, Jaufeerally F, Ling LH, Richards AM, van Melle JP, Voors AA, Lam CSP. Epicardial adipose tissue related to left atrial and ventricular function in heart failure with preserved versus reduced and mildly reduced ejection fraction Eur J Heart Fail. 2022 Aug;24(8):1346-1356. doi: 10.1002/ejhf.2513. Epub 2022 Jun 26.
Lo JJ, Yoon S, Neo SHS, Sim DKL, Graves N. Factors Influencing Potentially Futile Treatments at the End of Life in a Multiethnic Asian Cardiology Setting: A Qualitative Study Am J Hosp Palliat Care. 2022 Sep;39(9):1005-1013. doi: 10.1177/10499091211053624. Epub 2021 Dec 8.
Butt JH, Dewan P, Jhund PS, Anand IS, Atar D, Ge J, Desai AS, Echeverria LE, Køber L, Lam CSP, Maggioni AP, Martinez F, Packer M, Rouleau JL, Sim D, Van Veldhuisen DJ, Vrtovec B, Zannad F, Zile MR, Gong J, Lefkowitz MP, Rizkala AR, Solomon SD, McMurray JJV.Marc Sacubitril/Valsartan and Frailty in Patients with Heart Failure and Preserved Ejection Fraction J Am Coll Cardiol. 2022 Sep 20;80(12):1130-1143. doi: 10.1016/j.jacc.2022.06.037. Epub 2022 Aug 29.
Senni M, Alemayehu WG, Sim D, Edelmann F, Butler J, Ezekowitz J, Hernandez AF, Lam CSP, O'Connor CM, Pieske B, Ponikowski P, Roessig L, Voors AA, Westerhout CM, McMullan C, Armstrong Efficacy and Safety of Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction Treated with Sacubitril/Valsartan: Insights from the Victoria Trial Eur J Heart Fail. 2022 Sep;24(9):1614-1622. doi: 10.1002/ejhf.2608. Epub 2022 Jul 20.
Neo SH, Tan JY, Sim DK, Ng ES, Loh JKX, Yang GM, Murtagh FEM, Cheung YB Validity and Reliability of Integrated Palliative Care Outcome Scale in Asian Heart Failure Patients Palliat Med Rep. 2022 Nov 21;3(1):287-295. doi: 10.1089/pmr.2022.0029. eCollection 2022.
Anker SD, Butler J, Usman MS, Filippatos G, Ferreira JP, Bocchi E, Böhm M, Rocca HPB, Choi DJ, Chopra V, Chuquiure E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, González-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Piña IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Iwata T, Schnee JM, Brueckmann M, Pocock SJ, Zannad F Efficacy of Empagliflozin in Heart Failure with Preserved Ejection Fraction vs Mid Range Ejection Fraction: a Prespecified Analysis of Emperor Preserved Nat Med. 2022 Dec;28(12):2512-2520. doi: 10.1038/s41591-022-02041-5. Epub 2022 Dec 5.
NVarghese L, Lin W, Linden S, Lum AL, Sim D Cost-Effectiveness of Empagliflozin on Top of Standard of Care for Heart Failure With Reduced Ejection Fraction in Singapore Value Health Reg Issues. 2023 Mar;34:108-117. doi: 10.1016/j.vhri.2022.12.003. Epub 2023 Jan 18.
Teng TK, Tay WT, Ouwerkerk W, Tromp J, Richards AM, Gamble G, Greene SJ, Yiu KH, Poppe K, Ling LH, Lund M, Sim D, Devlin G, Loh SY, Troughton R, Ren QW, Jaufeerally F, Lee SGS, Tan RS, Soon DKN, Leong G, Ong HY, Yeo DPS, Lam CSP, Doughty RN Titration of medications and outcomes in multi-ethnic heart failure cohorts (with reduced ejection fraction) from Singapore and New Zealand ESC Heart Fail. 2023 Apr;10(2):1280-1293. doi: 10.1002/ehf2.14275. Epub 2023 Feb 1.
Lo JJ, Yoon S, Neo SHS, Sim DKL, Graves N. Elements of Potentially Inappropriate Interventions and Patient Prognostic Profiles at the End of Life in Cardiology: A Qualitative Analysis J Palliat Med. 2023 May;26(5):700-703. doi: 10.1089/jpm.2022.0564. Epub 2023 Feb 14.
Tay JCK, Chia SY, Koh SHM, Sim DKL, Chai P, Loh SY, Jaufeerally FR, Guang Lee SS, Yun Lim PZ, Yap J. Clinical characteristics and outcomes in Asian patients with heart failure with mildly reduced ejection fraction Singapore Med J. 2023 May 30. doi: 10.4103/singaporemedj.SMJ-2021-096. Online ahead of print.
Tromp J, van der Meer P, Tay WT, Ling LH, Loh SY, Soon D, Chin C, Jaufeerally F, Bamadhaj S, Ng TP, Lee SSG, Sim D, Yeo PSD, Leong GKT, Ong HY, Tantoso E, Eisenhaber F, Richards AM, Lam CSP. Diagnostic Accuracy of the Electrocardiogram for Heart Failure With Reduced or Preserved Ejection Fraction J Card Fail. 2023 Jul;29(7):1104-1106. doi: 10.1016/j.cardfail.2023.03.014. Epub 2023 Mar 31.
Tan ESJ, Chan SP, Liew OW, Chong JPC, Gerard Leong KT, Daniel Yeo PS, Ong HY, Jaufeerally F, Sim D, Ling LH, Lam CSP, Richards AM. Differential Associations of A-/B-Type Natriuretic Peptides With Cardiac Structure, Function, and Prognosis in Heart Failure JACC Heart Fail. 2023 Oct 13:S2213-1779(23)00620-0. doi: 10.1016/j.jchf.2023.09.011. Online ahead of print.
Butt JH, Claggett BL, Miao ZM, Jering KS, Sim D, van der Meer P, Ntsekhe M, Amir O, Cho MC, Carrillo-Calvillo J, Núñez JE, Cadena A, Kerkar P, Maggioni AP, Steg PG, Granger CB, Mann DL, Merkely B, Lewis EF, Solomon SD, Zhou Y, Køber L, Braunwald E, McMurray JJV, Pfeffer MA Geographic Differences in Patients with Acute Myocardial Infarction in the Paradise MI Trial Eur J Heart Fail. 2023 Aug;25(8):1228-1242. doi: 10.1002/ejhf.2851. Epub 2023 Apr 28.
Lo JJ, Tromp J, Ouwerkwerk W, Ong MEH, Tan K, Sim D, Graves N. Examining predictors for 6-month mortality and healthcare utilization for patients admitted for heart failure in the acute care setting Int J Cardiol. 2023 Nov 1;390:131237. doi: 10.1016/j.ijcard.2023.131237. Epub 2023 Aug 1.
van Essen BJ, Tharshana GN, Ouwerkerk W, Yeo PSD, Sim D, Jaufeerally F, Ong HY, Ling LH, Soon DKN, Lee SGS, Leong G, Loh SY, San Tan R, Ramachandra CJ, Hausenloy DJ, Liew OW, Chong J, Voors AA, Lam CSP, Richards AM, Tromp J. Distinguishing heart failure with reduced ejection fraction from heart failure with preserved ejection fraction: A phenomics approach Eur J Heart Fail. 2024 Feb 4. doi: 10.1002/ejhf.3156. Online ahead of print.
Mann DL, Nicolas J, Claggett B, Miao ZM, Granger CB, Kerkar P, Køber L, Lewis EF, McMurray JJV, Maggioni AP, Núñez J, Ntsekhe M, Rouleau JL, Sim D, Solomon SD, Steg PG, van der Meer P, Braunwald E, Pfeffer MA, Mehran R. Angiotensin Receptor-Neprilysin Inhibition in Patients With STEMI vs NSTEMI J Am Coll Cardiol. 2024 Mar 5;83(9):904-914. doi: 10.1016/j.jacc.2024.01.002.