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Clin Asst Prof Ong Boon Hean

Clin Asst Prof Ong Boon Hean

​MBBS, MRCSEd, FRCSEd (CTh), FAMS

Deputy Head and Senior Consultant

Service Chief (SGH Campus)

National Heart Centre Singapore

Specialty: Cardiothoracic Surgery

Sub-specialties: Cardiac Surgery (Adult), Thoracic Surgery, Lung Transplantation

Clinical Appointments

  • Deputy Head and Senior Consultant Department of Cardiothoracic Surgery National Heart Centre SingaporeNational Heart Centre Singapore
  • Service Chief @SGH Campus SingHealth Duke-NUS Lung Centre
  • Director, Lung Transplant Programme National Heart Centre SingaporeNational Heart Centre Singapore
  • Senior Consultant Thoracic Surgery Sengkang General HospitalSengkang General Hospital

Profile

Clinical Assistant Professor Ong Boon Hean is a Senior Consultant and Deputy Head (Thoracic) of the Department of Cardiothoracic Surgery and the Director of Thoracic Surgery at the National Heart Centre Singapore (NHCS). He graduated from the Faculty of Medicine, National University of Singapore in 2006. He subsequently completed his training in cardiothoracic surgery at the National Heart Centre Singapore and was admitted as a Fellow of the Royal College of Surgeons (Edinburgh) in 2014. He was then awarded the Singapore Ministry of Health-SingHealth HMDP Award in 2014 to pursue an advanced clinical fellowship in general thoracic surgery at Brigham and Women’s Hospital, Harvard Medical School in the United States of America.

In 2016, he returned from fellowship training to practice cardiothoracic surgery with subspecialty interests in minimally invasive thoracic surgery, thoracic oncology and lung transplantation at the National Heart Centre Singapore. He currently is the director of the lung transplant programme in the National Heart Centre Singapore, and service chief at the Singapore General Hospital campus for the SingHealth Duke-NUS Lung Centre.

He also previously served as the honorary secretary of the Chapter of Cardiothoracic Surgeons, Academy of Medicine Singapore. Aside from his clinical work, he is also actively involved in education and research in thoracic surgery. He is a core clinical faculty member of the National Heart Centre Singapore Cardiothoracic Residency program, a clinical lecturer with the Yong Loo Lin School of Medicine, National University of Singapore and an examiner for the Joint Committee on Specialist Training / Royal College of Surgeons (Edinburgh) Joint Specialty Fellowship Exit Examination in Cardiothoracic Surgery. He also a co-investigator for several studies related to lung cancer screening and novel treatment strategies for lung cancer.

Education

  • FAMS, 2016
  • FRCSEd (CTh), 2014
  • MRCSEd, 2008
  • MBBS National University of Singapore, 2006

Professional Appointments and Committee Memberships

  • Deputy Head (Thoracic), Department of Cardiothoracic Surgery, National Heart Centre Singapore, 15 January 2022 – Present
  • Senior Consultant, Department of Cardiothoracic Surgery, National Heart Centre Singapore, November 2021 – Present
  • Consultant, Department of Cardiothoracic Surgery, National Heart Centre Singapore 11/2016 – 10/2021
  • Director, Lung Transplant Programme, National Heart Centre Singapore 5/2019 – 4/2021
  • Director of Thoracic Surgery, National Heart Centre Singapore 2/2019 – 4/2021
  • Honorary Secretary, Chapter of Cardiothoracic Surgeons, Academy of Medicine Singapore 4/2019 – Present
  • Service Chief, SGH Campus, SingHealth Duke-NUS Lung Centre 4/2017 – 5/2021
  • Co-Chairperson, Cancer Service Line Development Lung Workgroup, National Cancer Centre 2/2017 – 2/2020
  • Member, Health Services Development Programme (HSDP) Technical Review Committee, SingHealth 4/2019 – Present
  • Organizing Chairperson, Singapore Uniportal VATS Masterclass 2019 11/2018 – 3/2019
  • Member, Scientific Committee, 4th Multi-Disciplinary Lung Cancer Conference 8/2018 – 3/2019
  • Surgical Director, Lung Transplant Programme, SingHealth Transplant 5/2018 – 4/2021
  • Member, SingHealth Transplant Executive Committee 5/2018 – 4/2021
  • Member, SingHealth Transplant Donation after Circulatory Death Committee 12/2017 – 5/2020
  • Organizing Chairperson, SingHealth Uniportal VATS Masterclass 2018, 11/2017 – 4/2018
  • Board Member, Chapter of Cardiothoracic Surgeons, Academy of Medicine Singapore 3/2017 – 4/2019
  • Member, Cardiothoracic Surgery Peer Review Learning Quality Assurance Committee, National Heart Centre 1/2017 – Present
  • Member, Cardiothoracic Surgery Program Evaluation Committee, National Heart Centre 6/2016 – Present
  • Member, Cardiothoracic Surgery Clinical Competency Committee, National Heart Centre 6/2016 – Present
  • Member, Tissue Review Committee, Singapore General Hospital, 5/2016 – 10/2018
  • Member, Joint Commission International Anaesthesia and Surgical Care Workgroup, National Heart Centre 5/2016 – 8/2017
  • Member, Inpatient Clindoc & Outpatient Paper-Light Initiative, National Heart Centre 2/2016 – Present
  • Clinical Assistant Professor, Duke-NUS Medical School
  • Clinical Lecturer, NUS Yong Loo Lin School of Medicine
  • Clinical Faculty Member, SingHealth Cardiothoracic Surgery Residency Programme

Awards

  • SingHealth Quality Service Bronze Award 2021
  • SingHealth Quality Service Gold Award 2020
  • Residency in SingHealth Excels (RiSE) Outstanding Faculty Award 2019
  • SingHealth Quality Service Silver Award 2019
  • SingHealth Game Changer Award 2018
  • SingHealth 10-Year Long Service Award 2018
  • SingHealth Quality Service Gold Award 2015
  • Human Manpower Development Plan Award 2014

Research Interests

  • Lung cancer screening
  • Lung cancer biomarker discovery and novel treatment strategies
  • Management of post-operative air leak
  • Video-assisted thoracoscopic surgery of the thymus
  • Post-operative atrial fibrillation
  • Extra-corporeal life support outcomes
  • Role of pre-op IV iron in cardiac surgery
  • Primary spontaneous hemopneumothorax

Publications

Original Articles

  • Association of Clinicopathologic and Molecular Tumor Features With Recurrence in Resected Early-Stage Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer. Saw SPL, Zhou S, Chen J, Lai G, Ang MK, Chua K, Kanesvaran R, Ng QS, Jain A, Tan WL, Rajasekaran T, Lim DWT, Tan A, Fong KW, Takano A, Cheng XM, Lim KH, Koh T, Ong BH, Tan EH, Toh CK, Skanderup AJ, Tan SH and Tan DSW. JAMA Netw Open. 2021 Nov 1;4(11):e2131892. doi: 10.1001/jamanetworkopen.2021.31892. PMID: 34739062.
  • Use of the extended pectoralis major myocutaneous flap as a wrap-around for mediastinal tracheal repair. Tan GH, Ong BH, Kok YO and Tan BK. JPRAS Open. 2021 Aug 11;30:133-137. doi: 10.1016/j.jpra.2021.07.009. PMID: 34568533; PMCID: PMC8449021
  • Customized Two-Dimensional Computed Tomography-Guided Preoperative Pectus Bar Shaping. Ho CWG, Tan BK, Ong BH, Nakao M and Lim CH. Ann Plast Surg. 2021 Jun 25. doi: 10.1097/SAP.0000000000002892. Epub ahead of print. PMID: 34176895.
  • Lung Cancer in Singapore. Ang YLE, Chia PL, Chua KLM, Devanand A, Leong CN, Liew CJY, Ong BH, Samol J, Seet JE, Tam JKC, Tan DSW, Teo LLS and Soo RA. J Thorac Oncol. 2021 Jun;16(6):906-911. doi: 10.1016/j.jtho.2020.11.020. PMID: 34034887.
  • Genomic landscape of lung adenocarcinoma in East Asians. Chen J, Yang H, Teo ASM, Amer LB, Sherbaf FG, Tan CQ, Alvarez JJS, Lu B, Lim JQ, Takano A, Nahar R, Lee YY, Phua CZJ, Chua KP, Suteja L, Chen PJ, Chang MM, Koh TPT, Ong BH, Anantham D, Hsu AAL, Gogna A, Too CW, Aung ZW, Lee YF, Wang L, Lim TKH, Wilm A, Choi PS, Ng PY, Toh CK, Lim WT, Ma S, Lim B, Liu J, Tam WL, Skanderup AJ, Yeong JPS, Tan EH, Creasy CL, Tan DSW, Hillmer AM and Zhai W. Nat Genet. 2020 Feb;52(2):177-186. doi: 10.1038/s41588-019-0569-6. Epub 2020 Feb 3.
  • Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and cost-effectiveness analysis. Tan AC, Lai GGY, Tan GS, Poon SY, Doble B, Lim TH, Aung ZW, Takano A, Tan WL, Ang MK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Lim AST, Lim WT, Toh CK, Tan EH, Lim TKH and Tan DSW. Lung Cancer. 2020 Jan;139:207-215. doi: 10.1016/j.lungcan.2019.11.022. Epub 2019 Nov 26
  • Prognostic Factors for Survival After Extracorporeal Membrane Oxygenation for Cardiogenic Shock. Huang M, Ong BH, Hoo AEE, Gao F, Chao VTT, Lim CH, Tan TE and Sin KYK. ASAIO J. 2019 Mar 6. doi: 10.1097/MAT.0000000000000984. [Epub ahead of print]
  • Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer. Lai GGY, Lim TH, Lim J, Liew PJR, Kwang XL, Nahar R, Aung ZW, Takano A, Lee YY, Lau DPX, Tan GS, Tan SH, Tan WL, Ang MK, Toh CK, Tan BS, Devanand A, Too CW, Gogna A, Ong BH, Koh TPT, Kanesvaran R, Ng QS, Jain A, Rajasekaran T, Yuan J, Lim TKH, Lim AST, Hillmer AM, Lim WT, Iyer NG, Tam WL, Zhai W, Tan EH and Tan DSW. J Clin Oncol. 2019 Apr 10;37(11):876-884. doi: 10.1200/JCO.18.00177.
  • The inaugural SingHealth uniportal video-assisted thoracoscopic surgery masterclass in Singapore. Ong BH and Gonzalez-Rivas D. J Vis Surg. 2018;4:200. doi: 10.21037/jovs.2018.09.1 
  • Video-assisted thoracoscopic surgery (VATS) resection of a right paratracheal ectopic thyroid: a case report. Tay WL, Hwang JS and Ong BH. J Vis Surg. 2018;4:125. doi: 10.21037/jovs.2018.06.1.
  • Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates. Simoni Y, Becht E, Fehlings M, Loh CY, Koo SL, Teng KWW, Yeong JPS, Nahar R, Zhang T, Kared H, Duan K, Ang N, Poidinger M, Lee YY, Larbi A, Khng AJ, Tan E, Fu C, Mathew R, Teo M, Lim WT, Toh CK, Ong BH, Koh T, Hillmer AM, Takano A, Lim TKH, Tan EH, Zhai W, Tan DSW, Tan IB, and Newell EW. Nature. 2018 May;557(7706):575-579. doi: 10.1038/s41586-018-0130-2. Epub 2018 May 16.
  • IL-11 is a crucial determinant of cardiovascular fibrosis. Schafer S, Viswanathan S, Widjaja AA, Lim WW, Moreno-Moral A, DeLaughter DM, Ng B, Patone G, Chow K, Khin E, Tan J, Chothani SP, Ye L, Rackham OJL, Ko NSJ, Sahib NE, Pua CJ, Zhen NTG, Xie C, Wang M, Maatz H, Lim S, Saar K, Blachut S, Petretto E, Schmidt S, Putoczki T, Guimarães-Camboa N, Wakimoto H, van Heesch S, Sigmundsson K, Lim SL, Soon JL, Chao VTT, Chua YL, Tan TE, Evans SM, Loh YJ, Jamal MH, Ong KK, Chua KC, Ong BH, Chakaramakkil MJ, Seidman JG, Seidman CE, Hubner N, Sin KYK and Cook SA. Nature. 2017 Dec 7;552(7683):110-115. doi: 10.1038/nature24676. Epub 2017 Nov 13.
  • The safe volume threshold for chest drain removal following pulmonary resection. Yap KH, Soon JL, Ong BH and Loh YJ. Interact Cardiovasc Thorac Surg. 2017 Nov 1;25(5):822-826. doi: 10.1093/icvts/ivx161.
  • Post-implantation transcatheter aortic valve migration in a left ventricular assist device patient with severe aortic insufficiency. Ong BH, Chiam PTL, Sim DKL and Tan TE. Eur Heart J. 2014 Jun 21;35(24)1616. doi: 10.1093/eurheartj/eht516.
  • Electrophysiology of human cardiac atrial and ventricular telocytes. Sheng J, Shim W, Lu J, Lim SY, Ong BH, Lim TS, Liew R, Chua YL and Wong P. J Cell Mol Med. 2014 Feb;18(2):355-62. doi: 10.1111/jcmm.12240.
  • Hydrogen sulphide suppresses human atrial fibroblast proliferation and transformation to myofibroblasts. Sheng J, Shim W, Wei H, Lim SY, Liew R, Lim TS, Ong BH, Chua YL and Wong P. J Cell Mol Med. 2013 Oct;17(10):1345-54. doi: 10.1111/jcmm.12114.
  • Two-stage operation for an extensive infected aortic arch. Nakao M, Lim YP, Jarmin MJ 3rd, Ong BH and Chua YL. J Thorac Cardiovasc Surg. 2010 Apr;139(4):1073-5.
  • Resection of giant malignant mediastinal peripheral nerve sheath tumor under cardiopulmonary bypass. Su JW, Chua YL, Ong BH and Lim CH. Singapore Med J. 2009 Jun;50(6):e199-200.

Review Articles
  • Molecular testing in stage I-III non-small cell lung cancer: Approaches and challenges .Aggarwal C, Bubendorf L, Cooper WA, Illei P, Borralho Nunes P, Ong BH, Tsao MS, Yatabe Y, Kerr KM. Lung Cancer. 2021 Sep 15;162:42-53. doi: 10.1016/j.lungcan.2021.09.003. Epub ahead of print. PMID: 34739853.
  • Revisiting neoadjuvant therapy in non-small-cell lung cancer. Saw SPL, Ong BH, Chua KLM, Takano A, Tan DSW. Lancet Oncol. 2021 Nov;22(11):e501-e516. doi: 10.1016/S1470-2045(21)00383-1. PMID: 34735819.
  • Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore. Chung SJ, Tan EK, Kee T, Krishnamoorthy TL, Phua GC, Sewa DW, Ong BH, Tan TE, Sivathasan C, Gan HLV, Goh BKP, Jeyaraj PR, Tan BH. Transplant Direct. 2020 May 8;6(6):e554. doi: 10.1097/TXD.0000000000001002.
  • Surgery versus stereotactic body radiotherapy in medically operable non-small cell lung cancer. Ong BH. J Xiangya Med 2018;3:26. Doi: 10.21037/jxym.2018.06.01
  • Human tracheal allograft banking: A Singapore experience and review on recent progress. Heng WL, Ong BH, Lim YP and Lim CH. J Transplant Technol Res 2013, 3:123. doi: 10.4172/2161-0991.1000123

Books and Chapters 
  • Mitral and tricuspid annuloplasty rings: what you need to know. Chua YL, Ong BH, Pang PY, and Lim SL. In: Saw HS, Dillon J, Chua YL and Al-Halees Z (Eds.). Managing the heart valve patient: How we do it (ISBN: 978-981-07-7226-0). Singapore: Colourscan; 2013. p.48-59.
  • Surgical management of prolonged air leak in patients with underlying emphysema. Ong BH, Tan BK and Lim CH. In: Mahadeva R (Ed.). Emphysema (ISBN: 978-953-51-0433-9). Croatia: InTech; 2012. p.103-34. doi: 10.5772/33359.

Research Trials