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Dr Chandramouli Nagarajan

MBBS, FRCP(Edin), FRCPath(UK)

Senior Consultant

Singapore General Hospital

Specialty: Haematology, Haematology

Sub-specialties: Lymphoma, Myeloma

Conditions Treated by this Doctor:
Acute Lymphocytic Leukemia (ALL), Aplastic Anaemia, Chronic lymphocytic leukemia, Chronic Myeloid Leukemia (CML), Deep Vein Thrombosis, Deep Vein Thrombosis, essential thrombocythemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndromes, Myelofibrosis, Polycythemia Vera, Thalassaemia.

Clinical Appointments

Myeloma Services Singapore General Hospital
Senior Consultant SingHealth Duke-NUS Blood Cancer Centre
Senior Consultant SingHealth Duke-NUS Transplant Centre
Senior Consultant Haematology Singapore General Hospital
Senior Consultant National Cancer Centre Singapore

Profile

Dr. Chandramouli is a Senior Consultant Haematologist and Transplant Physician at SingHealth Duke NUS Blood Cancer Center, SingHealth Duke NUS Transplant and Cell Therapy Center, Department of Haematology at Singapore General Hospital and the National Cancer Center.

After Graduate and Post-Graduate training and degrees from India, he underwent Haematology Sub-specialty training in the UK and obtained membership of the Royal College of Physicians, Fellowship of the Royal College of Pathology (FRCPath) and Haematology Specialist Accreditation. He served as a Consultant Haematologist in the Northwest of England for over 2 years before moving to Singapore. He was awarded the Clinical Research Training in Haematology Fellowship in 2018 by the European Haematology Association.

His main areas of focus are Myeloma and related plasma cell disorders, Lymphomas and lymphoproliferative disorders and Laboratory Haematology. He is a member of the Asian Myeloma Network, International Myeloma Working Group, International Myeloma Society and is the Sub-Specialty Director for Multiple Myeloma and Lymphoma in SGH and SingHealth-Duke NUS Blood Cancer Center. He is actively involved as a Principal Investigator in running clinical trials under the auspices of the International Myeloma Foundation and via active collaborations with Industry partners to bring Novel Therapies to South East Asia.

His other area of interest is clinical / medical education. He is an RCP accredited Educator and has been serving as the Programme Director for SingHealth Haematology Senior Residency Programme since 2018.

Education

FRCP (Edin)
FRCPath Haematology UK
MRCP (UK)
MD (Internal Medicine)
MBBS

Professional Appointments and Committee Memberships

Clinical Senior Lecturer, Yong Loo Lin School of Medicine
Clinical Assistant Professor, Duke-NUS Medical School.
Residency Programme Director, National and SingHealth Haematology Residency Program
Director of Education, SingHealth Duke-NUS Blood Cancer Center
Campus Service Chief, SingHealth-Duke NUS Cellular Therapy Center
Implementation Office, ACTRIS

Awards

EHA Clinical Research Training in Haematology Scholarship Award
Outstanding Residency Faculty Award
Service with a Heart Award
Singapore Health Quality Service Award

Research Interests

Publications

Kizhakeyil A, Zaini NBM, Poh ZS, Wong BHS, Loh X, Ng AS, et al. DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes. Vol. 20, Molecular Cancer. 2021. p. 134.
Chen Y, Nagarajan C, Tan MS, Martinelli G, Cerchione C. BCMA-targeting approaches for treatment of multiple myeloma. Panminerva Med [Internet]. 2021 Mar;63(1):28–36.
Lee LH, Nagarajan C, Tan CW, Ng HJ. Epidemiology of Cancer-Associated Thrombosis in Asia: A Systematic Review. Front Cardiovasc Med. 2021;8(May).
Ong SY, de Mel S, Grigoropoulos NF, Chen Y, Tan YC, Tan MSY, et al. High-dose methotrexate is effective for prevention of isolated CNS relapse in diffuse large B cell lymphoma. Blood Cancer J [Internet]. 2021 Aug 12;11(8):143.
Chen Y, Gopalakrishnan SK, Ooi M, Sultana R, Lim LH, Grigoropoulos N, et al. A phase 2 study of carfilzomib, cyclophosphamide and dexamethasone as frontline treatment for transplant-eligible MM with high-risk features (SGH-MM1). Vol. 11, Blood cancer journal. 2021. p. 150.
Ong SY, Lim JQ, Grigoropoulos N, Laurensia Y, Huang D, Chia BKH, et al. No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma. Vol. 106, Haematologica. 2021. p. 1737–9.
Nagarajan C, Tan MS, Chen Y, Martinelli G, Cerchione C. Current and future perspectives of maintenance therapy in multiple myeloma. Panminerva Med [Internet]. 2020 Dec;62(4):225–33.
Yeoh K-W, Thitsar SM, Master Z, Loh Y, Chen Y, Nagarajan C, et al. Pleural plasmacytomas - the role of radiotherapy. Vol. 190, British journal of haematology. England; 2020. p. e160–2.
Wang C, Soekojo CY, Mel S de, Ooi M, Chen Y, Goh AZK, et al. Natural History and Prognostic Factors at First Relapse in Multiple Myeloma. Cancers (Basel). 2020 Jul;12(7).
Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, et al. Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B(12) in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Nutrition. 2020;79–80:111017.
Ong SY, Phipps C, Nagarajan C, Tang T, Lim ST, Goh YT, et al. Cell-of-origin and bone marrow involvement increase specificity of defining patients with diffuse large B-cell lymphoma at high risk of CNS relapse: a study of 793 patients treated with chemoimmunotherapy in Asia. Vol. 61, Leukemia & lymphoma. United States; 2020. p. 225–7.
Lim CC, Lwin KZL, Cheong MA, Kanagasabapathy K, Nagarajan C, Loh A. An unusual cause of renal tubular dysfunction in multiple myeloma. Vol. 52, International urology and nephrology. Netherlands; 2020. p. 1603–5.
Pwint K-SW, Chen Y, Diong CP, Goh Y-T, Grant D, Ho A, et al. Mobilization kinetics of peripheral blood stem cells with rescue plerixafor - real-world experience from a single center. Vol. 61, Leukemia & lymphoma. United States; 2020. p. 1740–3.
Chew AHY, Chandramouli N, Kanesvaran R, Iyer GN, Hwang WYK. Winning the Fight Against Cancer. Ann Acad Med Singapore. 2020 Oct;49(10):779–88.
Abdul-Hamil NA, Wong GC, Nagarajan C, Martinelli G, Cherchione C. Midostaurin in acute myeloid leukemia: current evidence and practical considerations in routine clinical use. Minerva Med. 2020 Oct;111(5):443–54.
Soekojo CY, Wang G-M, Chen Y, Casan J, Wolyncewicz G, Lin A, et al. Role of Conventional Karyotyping in Multiple Myeloma in the Era of Modern Treatment and FISH Analysis. Clin Lymphoma Myeloma Leuk. 2019 Aug;19(8):e470–7.
Soekojo CY, Kim K, Huang S-Y, Chim C-S, Takezako N, Asaoku H, et al. Pomalidomide and dexamethasone combination with additional cyclophosphamide in relapsed/refractory multiple myeloma (AMN001)-a trial by the Asian Myeloma Network. Blood Cancer J. 2019 Oct;9(10):83.
Phipps C, Lee YS, Ying H, Nagarajan C, Grigoropoulos N, Chen Y, et al. The impact of time from diagnosis to treatment in diffuse large B-cell lymphoma. Leuk Lymphoma. 2018 Oct;59(10):2336–41.
Ong SY, Li S-T, Wong GC, Ho AYL, Nagarajan C, Ngeow J. Delayed diagnosis of Shwachman diamond syndrome with short telomeres and a review of cases in Asia. Vol. 9, Leukemia research reports. 2018. p. 54–7.
de Mel S, Chen Y, Gopalakrishnan SK, Ooi M, Teo C, Tan D, et al. The Singapore Myeloma Study Group Consensus Guidelines for the management of patients with multiple myeloma. Singapore Med J. 2017 Feb;58(2):55–71.
Nagarajan C, Barbieri A, Mittal S. Circulating tumour cells in disseminated malignant melanoma. Br J Haematol. 2012 Mar;156(6):692.