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Clin Assoc Prof Joan Khoo

Clin Assoc Prof Joan Khoo

MBBS, MMed (Int Med), MRCP (UK), FAMS (Endocrinology), FRCP Edin

Head & Senior Consultant

Chief & Senior Consultant

Changi General Hospital

Specialty: Endocrinology, Endocrinology

Sub-specialties: Diabetes, Obesity, Thyroid, Osteoporosis

Conditions Treated by this Doctor:
Diabetes Mellitus, Obesity, Osteoporosis, Osteoporosis.

Clinical Appointments

  • Chief Endocrinology Changi General HospitalChangi General Hospital
  • Head & Senior Consultant Endocrinology Changi General HospitalChangi General Hospital
  • Senior Consultant Endocrinology Changi General HospitalChangi General Hospital


Dr Joan Khoo is a Senior Consultant and current Chief of the Department of Endocrinology in Changi General Hospital (CGH). She received her medical degree from the National University of Singapore in 2000 and completed endocrinology specialist training in CGH.

After post-specialist fellowship training in the endocrinology of obesity and appetite regulation at the Royal Adelaide Hospital in Australia, she has been involved in multidisciplinary management of obese patients in CGH, and is a co-director of the Eastern Community Health Outreach (ECHO) community-based chronic disease prevention program.

Her clinical and research interests include diabetes, obesity and weight management.


  • ​FRCP (Edinburgh)
  • MMed Internal Medicine (National University of Singapore)
  • MRCP (UK)
  • MBBS (Singapore)

Professional Appointments and Committee Memberships

  • Advisory Board Member - Exercise Is Medicine Singapore
  • Board Member - Chapter of Endocrinologists, Academy of Medicine Singapore
  • Clinical Core Faculty - SingHealth Residency (Internal Medicine)
  • Clinical Associate Professor - Duke-NUS
  • Clinical Physician Faculty - SingHealth Residency (Endocrinology)
  • ​Clinical Senior Lecturer - NUS Yong Loo Lin School of Medicine
  • Council Member - Singapore Association for the Study of Obesity
  • FAMS (Endocrinology)
  • Member - MOH Clinical Trials Implementation Committee
  • Member - MOH Residency Advisory Committee (Endocrinology)


  • ​SingHealth Residency Outstanding Faculty Award 2017
  • Yong Loo Lin School of Medicine Dean's Teaching Award 2016
  • SingHealth Residency Outstanding Faculty Award 2016
  • Eastern Health Alliance Caring Awards (Star) 2014
  • Eastern Health Alliance Best Educator for Medical (Postgraduate) Award 2013
  • SingHealth Residency Outstanding Faculty Award 2013
  • CGH Gold Service Award 2013
  • Eastern Health Alliance Caring Awards (Gold) 2013
  • SingHealth Quality Assurance Award (Silver) 2011
  • SingHealth Talent Development Fund Medical Publication Award 2011
  • Lalor Foundation International Travel Award of the American Society of Andrology 2009
  • Ministry of Health Manpower Development Programme (HMDP) Award in "Endocrinology of Obesity and Appetite Regulation" 2008
  • SingHealth Best Registrar Award 2007

Research Interests

  • Endocrinology
  • Diabetes
  • Obesity and weight management


  • ​Khoo J, Hsiang J, Taneja R, Law NM, Ang TL. Comparative effects of liraglutide 3 mg versus structured lifestyle modification on body weight, liver fat and liver function in obese patients with non-alcoholic fatty liver disease: a pilot randomized trial. Diabetes Obes Metab. 2017;19:1814-1817
  • Gani L, Reddy SK, Alsuwaigh R, Khoo J, King TFJ. High prevalence of missed opportunities for secondary fracture prevention in a regional general hospital setting in Singapore. Arch Osteoporos 2017;12:60
  • Puar T, Khoo J, Ng KS, Kam JW, Wang KW. Correspondence on Adrenal vein sampling versus CT scanning in primary aldosteronism: an outcome-based randomized diagnostic trial. Lancet Diab Endocrinol 2016; 4:885-886
  • Thazhath SS, Marathe CS, Wu T, Chang J, Khoo J, Kuo P. The glucagon-like peptide 1 receptor agonist exenatide inhibits small intestinal motility, flow, transit, and absorption of glucose in healthy subjects and patients with type 2 diabetes: A Randomized Controlled Trial. Diabetes. 2016;65:269-75
  • Khoo J, Chen RYT, Wittert GA. The role of nutrition in male sexual function. Chapter 12, Nutrition, Fertility and Human Reproductive Function. 2015 1st ed. Tremellen, Kelton and Pearce, Karma (Eds.) CRC Press, Taylor and Francis Group. Boca Raton, FL., USA
  • Khoo J, Dhamodaran S, Chen DD, Yap SY, Chen RY, Tian HH. Exercise-induced weight loss is more effective than dieting for improving adipokine profile, insulin resistance and inflammation in obese men. Int J Sport Nutr Exerc Metab 2015; 25: 566-575
  • Kuan YC, Khoo J, TL Tay. Hypoglycemia and clinical outcomes in patients with diabetes mellitus admitted to the general ward in a hospital in Singapore. Endocr Pract 2014; 20:1039-94
  • Khoo J, Ling PS, Chen RYT et al. Comparing effects of meal replacements with isocaloric reduced-fat diet on nutrient intake and lower urinary tract symptoms in obese men. J Hum Nutr Diet 2014; 27:219-226
  • Comparing effects of liraglutide and bariatric surgery on weight loss, liver function, body composition, insulin resistance, endothelial function and biomarkers of non-alcoholic steatohepatitis (NASH) in obese Asian adults: CGH-LiNASH (National Medical Research Council Centre Grant NMRC/CG/002/2013)
  • Fock KM, Khoo J. Diet and exercise in management of obesity and overweight. J Gastroenterol Hepatol.2013; 4:59-63
  • Young RL, Chia B, Isaacs NJ, Ma J, Khoo J, Wu T, Horowitz M. Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes 2013 62:3532-41
  • Khoo J, Tian HH, Tan B et al. Comparing effects of low- and high-volume moderate-intensity exercise on sexual function and testosterone in obese men. J Sex Med 2013;10:1823-32
  • Puar TH, Khoo JJ, Cho LW et al. Association between glycemic control and hip fracture. J Am Ger Soc 2012; 60:1493-7
  • Khoo J, Chen RYT, Wittert GA. Obesity, in Pathy's Principles and Practice of Geriatric Medicine, Volume 1 & 2, Fifth Edition 2012  (eds A. J. Sinclair, J. E. Morley and B. Vellas), John Wiley & Sons, Ltd, Chichester, UK.
  • Khoo J, Tay TL, Foo JP et al. Sensitivity of A1C to diagnose diabetes is decreased in high-risk older Southeast Asians. J Diabetes Complications 2012; 26:99-101
  • Khoo J, Piantadosi C, Duncan R et al. Comparing effects of a low-energy diet and a high-protein low-fat diet on sexual and endothelial function, urinary tract symptoms, and inflammation in obese diabetic men. J Sex Med 2011; 8:2868-75
  • Khoo J, Rayner CK, Feinle-Bisset C, Wittert G. Role Of The Gastrointestinal Tract In Peptide Hormone Release And Appetite. Chapter 68, Handbook of Behavior, Food and Nutrition. 2011 1st ed. Preedy, Victor R.; Watson, Ronald Ross; Martin, Colin R. (Eds.) New York, Springer Inc.
  • Khoo J, Rayner CK, Feinle-Bisset C, Jones KL, Horowitz M. Gastrointestinal hormonal dysfunction in gastroparesis and functional dyspepsia. Neurogastroenterol Motil 2010;22:1270-8
  • Khoo J, Piantadosi C, Worthley S, Wittert G. Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men. Int J Obes 2010;34:1396-403
  • Khoo J, Rayner CK, Jones KL, Horowitz M. Incretin-Based Therapies: New Treatments For Type 2 Diabetes In The New Millennium. Ther Clin Risk Manag. 2009;5:683-98

Research Trials