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Prof Jerry Chan Kok Yen

Prof Chan Kok Yen Jerry

MB BCh BaO (Hons), MA MRCOG FRCOG PhD FAMS (OBGYN & Clinician Scientist)

Senior Consultant

KK Women's and Children's Hospital

Specialty: Reproductive Medicine, Obstetrics & Gynaecology

Sub-specialties: Assisted Reproductive Program, Infertility, Reproductive Surgery, Endometriosis, Polycystic Ovarian Syndrome, Andrology, Obstetrics & Gynaecology

Clinical Appointments

  • Senior Consultant Reproductive Medicine KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Director KK Research Centre KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Director, Maternal and Child Health Research Institute, KKH, SingHealth Duke-NUS

Academic Appointments

  • Professor SingHealth Duke-NUS Obstetrics & Gynaecology Academic Clinical Programme


Dr Chan read Medicine at Trinity College Dublin, graduating with Honours and first in his class in 1997. He began his postgraduate residency in England, mainly in Manchester and London. He completed the rest of his OBGYN training in Singapore in 2009, and a fellowship in Reproductive Endocrinology and Infertility in 2011, and is a practising accredited specialist in in Assisted Reproductive Technique in KK Women's and Children Hospital. He is a fellow of the Royal College of Obstetrician and Gynaecologist in London.

Dr Chan completed a PhD in intrauterine stem cell therapies at Imperial College London. Thereafter, he returned to Singapore and started the Experimental Fetal Therapy laboratory, with a primary focus in developing novel fetal molecular therapies in the form of gene transfer and stem cell transplantation. Since then, he has been continuously funded by major grant funding bodies for his research, and has supervised over 12 PhD students successfully. He has published over 170 papers, including prestigious journals such as The Lancet, Nature, Cell, Science, Immunity, PNAS, Blood, Stem Cells among others.


  • FRCOG, Fellow – Royal College of Obstetricians & Gynaecologists (UK) 2014
  • Assisted Reproductive Techniques Accreditation (Singapore) 2011
  • FAMS, Fellow – Academy of Medicine, Singapore (OBGYN & CS) 2009 / 2016
  • PhD, Imperial College London. University of London (UK) 2006
  • MRCOG, Member - Royal College of Obstetricians & Gynaecologists (UK) 2001
  • DFFP, Dip. of Faculty of Family Planning, RCOG (UK) 2000
  • MB BCh BaO (Hons) MA, Trinity College, University of Dublin (Ireland) 1997

Professional Appointments and Committee Memberships

  • Associate Professor, Program in Cancer and Stem Cell Biology
  • Associate Professor (Joint), Principal Investigator - Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, NUS, Singapore
  • Associate Professor (Honorary), University of Queensland Centre for Clinical Research, University of Queensland, Australia
  • Adjunct Principal Investigator, Singapore Immunology Network, A*STAR, Singapore
  • Member, Board of Academy of Medicine, Clinician Scientist, 2017 – Present
  • Member, Academic Medicine Education Institute, 2013 – Present
  • Member, SingHealth Grant Review Committee – Clinical, 2012 – Present
  • Mentor, SingHealth OBGYN Residency Clinician-Scientist Track, 2010 – Present
  • Member – Singapore Stem Cell Consortium, 2010 – Present


  • NMRC Clinician Scientist Award (Senior Investigator), 2017-2021
  • Singapore Health Quality Service – Star Award, 2017
  • Singapore Health Quality Service – Silver Award, 2014
  • Distinguished Researcher Award – SingHealth Excellence Awards, Singapore, 2013
  • 22nd Benjamin Henry Sheares Memorial Lecture. Intrauterine Stem Cell Transplantation and Gene Therapy. OGSS. Singapore International Congress of Obstetrics and Gynaecology, 2011.

Research Interests

  • Fetal Stem Cells and its downstream application for
    i. Developmental biology / Intra-uterine gene / stem cell therapy
    ii. Tissue Engineering & Regenerative Medicine
  • Intrauterine Therapy – Cellular and Gene Therapy
  • Non-human primate models of human reproduction and fetal therapy
  • Reproductive Medicine
    i. Ovarian reserve testing / Fertility Preservation
    ii. Endometriosis – Pathogenesis and Biomarkers
    iii. Reproductive Biology and Assisted Reproductive Techniques
    iv. Pharmacotherapeutics in IVF and Ovulation Induction


  • Giiula Massaro, Citra N Mattar, Andrew MS Wong, Ern`esta Sirka, Suzanne Buckley, Bronwen R Herbert, Stefan Karlsson, Dany P Perocheau, Derek Burke, Simon Heales, Angela Richard-Londt, Sebastian Brandner, Mylene Huebeker, David A Priestman, Frances M Platt, Kevin Mills, Arijit Biswas, Johnathan Cooper, Jerry K Y Chan, Seng H Cheng, Simon N Waddington, Ahad A Rahim. Fetal gene therapy for neurodegnerative disease of infants. Nature Medicine 2018 (IN PRESS).
  • Naomi McGovern, Amanda Shin, Gillian Low, Donovan Low, Kaibo Duan, 
 Leong Jing Yao, Rasha Msallam, Ivy Low, Nurhidaya Binte Shadan, Hermi R 
Sumatoh, Erin Soon, Josephine Lum, Esther Mok, Sandra Hubert, Peter See, 
Edwin Huang Kunxiang, Mahesh Choolani, Citra Nurafah Zaini Mattar, Fan Yiping, Tony Kiat Hon Lim, John Kit Chung Tam, Christopher Schuster, 
Adelheid Elbe-Bürger, Michael Poidinger, Xiao Wang8, Venetia Bigley, 
Matthew Collin, Muzlifah Haniffa, Salvatore Albani, Anis Larbi, Evan W Newell, Jerry Kok Yen Chan* and Florent Ginhoux*. 
Human fetal dendritic cells promote pre-natal T cell immune-suppression through Arginase 2 activity. Nature. 2017 Jun 29;546(7660):662-666. *Joint Last and Corresponding Author
  • Citra Mattar, Irene Gil-Farina, Cecilia Rosales, Nuryanti Johana, Yvonne Yi Wan Tan, Jenny McIntosh, Christine Kaeppel, Simon N Waddington, Arijit Biswas, Mahesh Choolani, Manfred Schmidt, Amit C Nathwani, Jerry KY Chan. In-utero transfer of adeno-associated vectors produces long-term Factor IX levels in a cynomolgus macaque model. Molecular Therapy 2017 Apr 24
  • Fok-Moon Lum, Donavan KS Low, Yiping Fan, Jeslin JL Tan, Bernett Lee, SIgN Immune-monitoring platform, Jerry KY Chan, Laurent Renia, Florent Ginhoux, Lisa FP Ng. Zika virus infects human brain fetal microglia and induces a strong inflammatory response. Clinical Infectious Diseases 2017 Apr 1;64(7):914-920
  • Yie Hou Lee, Chin Wen Tan, Abhishek Venkatratnam, Ee Jia Teoh, Liang Cui, Seong Feei Loh, Linda Griffith, Steven R Tannenbaum, Jerry Kok Yen Chan. Dysregulated sphingolipid metabolism in endometriosis. JCEM 2014 Oct;99(10):E1913-21
  • Cecilia Gotherstrom, Magnus Westgren, Steven Shaw, Eva Astrom, Arijit Bistwas, Peter h Byers, Citra N Z Mattar, Gail E Graha, Jahan Taslimi, Uwe Ewald, Nicholas M Fisk, Allen E JW Yeoh, Ju-Li Lin, Po-Jen Cheng, Mahesh Choolani, Katarina Le Blanc and Jerry K Y Chan. Pre and postnatal transplantation of fetal mesenchymal stem cells in osteogenesis imperfecta: a two-center experience. Stem Cells Transl Med. 2014 Feb;3(2):255-64
  • Zhi-Yong Zhang, Swee-Hin Teoh, Mark SK Chong, Jan Thorsten Schantz, Nicholas M Fisk, Mahesh A Choolani, Jerry Chan. Superior osteogenic capacity for bone tissue engineering of fetal compared to perinatal and adult mesenchymal stem cells. Stem Cells 2009 Jan;27(1):126 –137
  • Chan J, Waddington SN, O’Donoghue K, Kurata H, Guillot P, Gotherstrom C, Themis M, Morgan JE, Fisk NM. Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse. Stem Cells 2007;25(4);875-884.
  • O’Donoghue K, Chan J, de la Fuente J, Kennea N, Sandison A, Anderson JR, Roberts IAG, Fisk NM. Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem cell trafficking in pregnancy. The Lancet 2004 (364)179-82. 

Research Trials