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Dr Huang Jingxiang


MBBS (NUS, Singapore), MD (NUS, Singapore), PhD (Harvard U, US), FRCPath (RCPath, UK), FRCPA (RCPA, Australia)

Head & Senior Consultant

Sengkang General Hospital

Specialty: Anatomical Pathology, Pathology

Clinical Appointments

  • Head & Senior Consultant Department of Pathology Sengkang General HospitalSengkang General Hospital



MBBS (NUS, Singapore)

MD (NUS, Singapore)

PhD (Harvard U, US)

FRCPath (RCPath, UK)

FRCPA (RCPA, Australia)

Professional Appointments and Committee Memberships

​Adjunct Assistant Professor, NUSMedicine


Research Interests


Book Chapter

An in vitro assay for the kinase activity of mTOR complex 2. Huang J (2012). In Weichhart T. (Ed.), mTOR - Methods and Protocols. Methods in Molecular Biology (Vol. 821, pp 75-86). Springer.

Selected Reviews

A complex interplay between Akt, TSC2 and the two mTOR complexes. Huang J, Manning BD. Biochem Soc Trans. 2009 Feb; 37(Pt 1): 217-22.

The TSC1-TSC2 complex: A molecular switchboard controlling cell growth. Huang J, Manning BD. Biochem J. 2008 Jun; 412(2): 179-90.

Metallothionein as a prognostic biomarker in breast cancer. Bay BH, Jin R, Huang J, Tan PH. Exp Biol Med. 2006 Oct; 231(9): 1516-21.

The significance of autophagy in cancer. Ng G, Huang J. Mol Carcinog. 2005; 43(4): 183-7.

Selected Publications

Pemetrexed-induced lower limb pseudocellulitis.  Liau MM, Santosa A, Huang J, Tan LC. Clin Exp Dermatol. 2017 Dec; 42(8): 914-916

Hypokalaemia in Sjogren's Syndrome: The Missing Piece. Umer FK, Lee CT, Tan KB, Huang J, Wong AL. Clin Med (Lond) 2017 Jan; 17(1): 40-2

Bilateral lower limb tender nodules. Lee LJ, Liau MM, Lee CT, Huang J, Tan LC. J Am Acad Dermatol. 2016 Nov;75(5):e177-e178

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.  Tan SH, Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk MR, Shen HM.  Autophagy. 2014 Feb 1;10(2):226-42.

Intracerebral metaplastic meningioma with prominent ossification and extensive calcification. Huang J, Petersson F. Rare Tumors. 2011 Apr 4;3(2):e20.

Low-grade renal carcinoma with histologic features overlapping with renal angiomyoadenomatous tumor and featuring polysomy 7 and 17 and a mutation in the von Hippel-Lindau gene: report of a hybrid tumor and a few comments on renal angiomyoadenomatous tumor and papillary renal tumors with clear cells. Petersson F, Yan B, Huang J, Thamboo TP, Bing TK, Consigliere DT.  Ann Diagn Pathol. 2011 Jun;15(3):213-6.

Epstein-Barr Virus-associated smooth muscle tumor mimicking cutaneous angioleiomyoma.  Petersson F, Huang J.  Am J Dermatopathol. 2011 Jun;33(4): 407-929.

Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma. Huang J, Loh KS, Petersson F. Head Neck Pathol. 2010 Dec; 4(4): 300-4.

Signaling events downstream of mTOR complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Huang J, Wu S, Wu C-L, Manning BD. Cancer Res. 2009 Aug; 69(15): 6107-14.

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. Zhang HH, Huang J, Duvel K, Boback B, Wu S, Squillace RM, Wu C-L, Manning BD.  PLoS ONE. 2009 Jul; 4(7): e6189.

Over-expresssion of metallothionein predicts chemoresistance in breast cancer. Yap X, Tan HY, Huang J, Lai Y, Yip GW, Tan PH, Bay BH.  J Pathol. 2009 Mar; 217(4): 563-570.

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Huang J, Dibble CC, Matsuzaki M, Manning BD.  Mol Cell Biol. 2008 Jun; 28(12): 4104-15.

Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with adverse clinical outcome. Ng G, Winder D, Muralidhar B, Gooding E, Roberts I, Pett M, Mukherjee G, Huang J, Coleman N. J Pathol. 2007 Jul; 212(3): 325-34.

Defining ploidy-specific thresholds in array comparative genomic hybridization to improve the sensitivity of detection of single copy alterations in cell lines. Ng G, Huang J, Roberts I, Coleman N.  J Mol Diagn. 2006 Sep; 8(4): 449-58.

Y-box binding protein, YB-1, as a marker of tumor aggressiveness and clinical response to adjuvant chemotherapy in breast cancer. Huang J, Tan PH, Li K-B, Matsumoto K, Tsujimoto M, Bay BH.  Int J Oncol. 2005 Mar; 26(3): 607-13.

Prognostic significance of glutathione S-transferase-pi in invasive breast cancer. Huang J, Tan PH, Thiyagarajan J, Bay BH. Mod Pathol. 2003 Jun; 16(6): 558-65.

Nuclear morphology in breast cancer: is pleomorphism an illusion? Huang J, Bay BH, Tan PH. Med Hypotheses. 2000 Jul; 55(1): 26-8.

Research Trials