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Dr Goh Eyleen

Dr Goh Eyleen

National Neuroscience Institute

Profile

Dr Eyleen Goh's general interest is to determine how stem cells in the developing and adult brain can differentiate and develop into new neurons and functionally integrate into the existing circuitry. Using in vitro and in vivo assays established in the lab combining mouse genetics, anti-sense RNA technology, retroviral and lentiviral strategies, CRISPR-mediated KO or point mutations, in utero electroporation, stereotaxic injections, electrophysiology and animal behavior test, Dr Goh's team examines both intrinsic and extrinsic mechanisms responsible for neurogenesis in the developing and matured adult brain, and also studies the associated cognitive functions (Ge and Goh et al., Nature, 2006; Shim et al., Nature Neurosci., 2005; Goh et al., Mol. Brain, 2008; Shivaraj et al., PLOS one, 2012; Ng et al., PLOS one, 2013; Chew et al., Frontiers in Behav. Neurosci., 2015; Ng et al., J. Biol. Chem., 2016).

Dr Goh's team extended their research activities from understanding the fundamentals of neurogenesis to understanding and treatment of neurodevelopmental, neuropsychiatric disorders and dementia using animal models, human embryonic stem cells and patients derived pluripotent stem cells – through deciphering their common mechanisms and signalling pathways.

Education

  • Post-doctoral fellowship, Institute for Cell Engineering/ Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA (Hongjun Song, Guo-li Ming, mentors), ​​2008
  • PhD. Institute of Molecular and Cell Biology, National University of Singapore, Republic of Singapore. (Peter Lobie, mentor), 2003
  • B.Sc. (Hons. Mol. Biol.), University of Edinburgh, Scotland, United Kingdom, 1996

Professional Appointments and Committee Memberships

  • Principal Investigator / Senior Research Scientist, National Neuroscience Institute, Singapore
  • Assistant Professor, SingHealth Duke-NUS Neuroscience Academic Clinical Programme, Singapore
  • Associate Professor, Neuroscience and Mental Health Faculty, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
  • ​Member of Association for the Study of Neurons and Diseases (AND), 2013 - Present
  • Member of Asia Pacific Society for Neurochemistry (APSN), 2010 - Present
  • Member of The Society for Neuroscience (SfN), 2003 - Present
  • Treasurer of The Society for Neuroscience (SfN), Singapore Chapter, 2010 - 2016
  • Associate member of The Endocrine Society, 1998 - 2003

Awards

  • ​Khoo Bridge Funding Award, Duke-NUS Medical School, Singapore, 2018

Research Interests

  • ​Neuroregeneration
  • Neurodevelopment
  • Neuroinflammation
  • Dementia and aging

Publications

  • Chin EW, Lim WM, Ma DL, Rosales F and Goh EL (2018) Choline rescues behavioural deficits in a mouse model of RTT by modulating neuronal plasticity. Molecular Neurobiology, 56(6), 3882-3896, doi: 10.1007/s12035-018-1345-9 (IF: 6.19)
  • Hor CH and Goh EL (2018). Rab23 Regulates Radial Migration of Projection Neurons via N-cadherin. Cerebral Cortex, 28(4): 1516-1531. Cover images of the printed issue. (IF: 8.285)
  • Yan TD, Ooi WF, Qamra A, Cheung A, Ma DL, Sundaram G, Xu C, Xing M, Poon L-F, Wang J, Loh YP, Ho JH, Ng J, Ramlee M, Aswad L, Rozen S, Ghosh S, Bard F, Sampath P, Tergaonkar V, Davies J, Hughes J, Goh EL, Bi X, Fullwood M, Tan P, and Li S (2018) HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis. Nature Comm. 9(1): 100 (IF: 12.124)
  • Adriani G, Ma DL, Pavesi A, Kamm RD and Goh EL (2017) A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as blood-brain barrier. Lab on a Chip, 17: 448-459 (IF: 6.115)
  • Nguyen NL, Ma DL, Shui GH, Wong PY, Zhang XD, Wenk MR, Goh EL and Silver DL (2014) Major Facilitator Superfamily Domain 2a (Mfsd2a) is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature, 509: 503-06. (IF: 36.28)

Research Trials

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