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Clin Asst Prof Eugene Wong Yu Jun

Clin Asst Prof Wong

MD, MMed (Int Med), MRCP (UK), MCI, FRCP (Edin), FAMS

Consultant

Changi General Hospital

Specialty: Gastroenterology

Clinical Appointments

  • Consultant Gastroenterology and Hepatology Changi General HospitalChangi General Hospital

Academic Appointments

  • Clinical Assistant Professor, Duke-NUS Medical School, Singapore
  • Adjunct Instructor, Yong Loo Lin School of Medicine, National University of Singapore
  • Adjunct Instructor, Lee Kong Chian School of Medicine, Nanyang Technology University
  • Core Faculty, Internal Medicine Junior Residency, SingHealth

Profile

Dr Wong graduated from the Faculty of Medicine, National University of Malaysia in 2010 before obtaining his Master of Medicine (Internal Medicine) from the National University of Singapore in 2013. He was the Chief Resident for Internal Medicine Residency (SingHealth) from 2014 to 2015, and completed his Senior Residency in Gastroenterology in 2018. Currently, Dr Wong is a Consultant with the Department of Gastroenterology and Hepatology at Changi General Hospital (CGH).

Dr Wong has a strong passion for improving patient care through clinical research. He has published extensively in peer-reviewed journals and won numerous awards for his research works, including the prestigious Early Career Investigator Award in Clinical/Translational Science by the American Association of the Study of Liver Disease (AASLD) in 2022. He completed his Master of Clinical Investigator (MCI) in 2021 and was awarded the Nurturing Clinician Scientist Scheme by the Joint Office of Academic Medicine, SingHealth in 2020.

As a research mentor from Duke-NUS Medical School, Dr Wong had also mentored many medical students and junior colleagues in their research projects; which had led to award-winning abstracts (AASLD Foundation Fellowship Award 2022, SingHealth Medical Student Talent Development Award 2022, first runner-up for oral presentation in GIHEP 2022, first and second runner-up for poster presentation in GIHEP 2022) and publications in peer-reviewed journals. Dr Wong was awarded the Senior Educator Award, twice, in 2020 and 2022, for his effort in undergraduate and postgraduate medical education.

Education

  • Master of Clinical Investigation (MCI) National University of Singapore, 2020
  • European Specialty Examination in Gastroenterology & Hepatology, 2019
  • Specialist Accreditation Board (Gastroenterology) 2018
  • MMed (Int Med) National University of Singapore 2013
  • MD, National University of Malaysia 2010

Professional Appointments and Committee Memberships

  • Consultant, Department of Gastroenterology & Hepatology, Changi General Hospital (2021 – Present)
  • Fellow, Academy of Medicine Singapore (2020 – Present)
  • Fellow, Royal College of Physicians Edinburg (2021 – Present)
  • EXCO Member, Gastroenterology Society of Singapore (2021 – Present)
  • Social Media Ambassador & Member, European Association of the Study of Liver Disease (EASL) (2021 – Present)

Awards

  • AASLD Foundation Award, AASLD The Liver Meeting, 2022
  • AASLD Presidential Plenary Lecture, Digestive Disease Week, 2022
  • SingHealth Publish! Award, Medicine ACP, SingHealth, 2022
  • Human Manpower Development Program, Ministry of Health, 2022
  • Senior Educator Award, Medicine ACP, SingHealth, 2022
  • Best Oral Presentation, GIHEP Singapore, 2021
  • Best Oral Presentation, GIHEP Singapore, 2018
  • 1st Runner Up, Oral Presentation, GIHEP Singapore, 2022
  • 2nd Runner Up, Oral Presentation, GIHEP Singapore, 2022
  • 1st Runner Up, Poster Presentation, GIHEP Singapore, 2022
  • 2nd Runner Up, Video presentation, GIHEP, 2018
  • Poster of Distinction, Digestive Disease Week, 2021
  • Quality Improvement Project Award, RISE Award, SingHealth, 2021
  • Nurturing Clinician Scientist Award (NCSS), Joint Office of Academic Medicine, SingHealth, 2020
  • Senior Educator Award, Medicine ACP, SingHealth, 2020
  • Silver Award, Singapore Health Quality Service Award, SingHealth, 2020
  • MOH Healthcare Scholarship, National Medical Research Council, Ministry of Health, 2020
  • Outstanding Resident Award, SingHealth, 2018
  • Outstanding Resident Award, SingHealth, 2015
  • Outstanding Resident Award, SingHealth, 2013
  • RISE Award (Research sub-committee, community service sub-community), SingHealth Resident Committee, 2014 & 2015

Research Interests

  • Cirrhosis and portal hypertension
  • Viral hepatitis
  • Cost-effectiveness study
  • Meta-analysis

Publications

  1. Thomas M, Andrew M, Jonathan AC, Sherief AE, Costica A, Armstrong MJ, Pose E, Brenner E, Catana MA, Renumathy D, Ahad E, Ignacio GJ, Gill US, Jones PD, Kennedy J, Marshall A, Matthews C, Mells G, Mercer C, Perumalswami PV, Avitabile E, Qi X, Su F, Ufere NN, YJ Wong, Zheng MH, Barnes E, Barritt AS, Webb GJ. Outcome following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study. Accepted for publication in the Journal of Hepatology 2020. Doi: https://doi.org/10.1016/j.jhep.2020.09.024. (IF 25.1)
  2. M Putera, Teh KB, R Kumar, YJ Wong. Small esophageal varices in compensated cirrhosis patients: to treat or not to treat? Accepted in J Hepatol [early view] (IF: 25.1)
  3. YJ Wong, MH Nguyen. Is it safe to treat chronic hepatitis C patients with decompensated cirrhosis with protease inhibitor-based direct-acting antiviral? Journal of Hepatology 2022, PMID: 35074472 (IF 25.1)
  4. CK Tan, YJ Wong, LM Wang, TL Ang, R Kumar. Autoimmune hepatitis following COVID-19 vaccination: True causality of mere association? Journal of Hepatology 2022, PMID: 8404983 (IF 25.1),
  5. Ng K, Poon BH, Puar HK, Quah LS, Loh WJ, YJ Wong, Tan TY, J Raghuram. Covid-19 and the risk of Health Care Workers: A case report. Ann Intern Med 2020. doi:10.8326/L20-0175. (Impact factor: 19.1)
  6. C Liu*, Z Cao*, H Yan*, YJ Wong*, Q Xie*, H Masashi*, Hirayuki E*, TH Kim*, AS Hanafy*, Y Liu, YF Huang, X Li, N Kang, K Yohei, H Yoichi, N Takashi, I Hiroko, YK Jung, HJ Yim, G Ying, L Zhang, JMa, M Kumar, J Ankur, KB The, S Sarin, Xiaolong Qi. A novel SAVE score to stratify decompensation risk in compensated advanced chronic liver disease: an international multicenter cohort study. American Journal of Gastroenterology June 15 2022, doi: 10.14309/ajg.00000000001873 [IF 10.3]
  7. YJ Wong, Z Chen, Tosetti G, Degasperi E, Sharma S, Agarwal S, Liu C, YH Chan, J Li, X Qi, S Anoop, Primignani M. Baveno-VII criteria to predict decompensation and initiate non-selective beta-blocker in compensated advanced chronic liver disease patients. Clin Mol Hepatol 2022. Doi: 10.3350/cmh.2022.0181 [IF: 8.33]
  8. YJ Wong, Jia Li, Chuan Liu, Zhaojin Chen, Yiong Huak Chan, Martin Putera, Kok Ban Teh, Tiing Leong Ang, Lili Zhao, Zhongyang Yan, Rahul Kumar, Xin LI, Xiaolong Qi. CHES-ALARM score to stratify decompensation risk in compensated advanced chronic liver disease patients: an international multicenter study. Journal of Gastroenterology & Hepatology 2022, PMID: 35253271 [IF 4.0]
  9. B Choo, GBB Goh, SY Chia, HC Oh, NC Tan, Jessica Tan, TL Ang, YM Bee, YJ Wong. Non-alcoholic fatty liver disease in type-II Diabetes Mellitus: A cost-effectiveness and price-threshold analysis. Accepted in Annals of Academy of Medicine Singapore 2022. IF 8.71
  10. YJ Wong, PH Thurairajah, R Kumar, Fock KM, NM Law, Sy Chong, FG Manejero, Ang TL, Teo EK, J Tan. The impact of unrestricted access to direct-acting antiviral among incarcerated hepatitis C virus-infected patients. Accepted in Clinical Molecular Hepatology [IF 6.07]
  11. YJ Wong, Rahul Kumar. Follow-up paracentesis in spontaneous bacterial peritonitis: prognostic, but may not improve survival. Accepted in press in Clinical Gastroenterol Hepatol 2021. (IF: 11.38)
  12. YJ Wong. Editorial: an elastography-based two-step approach to detect NAFLD with compensated advanced chronic liver disease. Aliment Pharmacol Ther 2021; 54: 515-516. IF: 8.17
  13. Daphne Ang, Seok Hwee Koo, Yiong Huak Chan, Thean Yen Tan, Gaik Hong Soon, Chin Kimg Tan, Kenneth Weicong Lin, Jaydeesh-Khanna Krishnmasamy-Balasubramaniam, YJ Wong, Rahul Kumar, Rajesh R, Yiyuan Tan, Jeannie Ong, Jessica Tan, James Li, Andrew Kwek, Tiing Leong Ang. Clinical trial: seven-day vonoprazan versus 14-day proton pump inhibitor-based triple therapy for first-line Helicobacter pylori eradication. Alimentary Pharmacology and Therapiutics 2022. Httpw://doi.orh/10.1111/apt.17070 (IF 8.17)
  14. YJ Wong (2018). Cytomegalovirus infection in an immunocompetent patient. Gastrointest Endosc 88(6): 969-970. (Impact Factor: 7.204)
  15. Yifei Huang, Li JiA, Tianlei Zheng, Dong JI, YJ Wong, Hong You, Ye Gu, Li M< Zhao L, Li S, Geng S, Yang N, Chen G, Wang Yan, Kumar M, Jindal A, Qin W, Chen Z, Xin Y, Jiang Z, Chi X, Cheng J, Zhang M, Liu H, Lu M, Li L, Zhang Y, Pu C, Ma D, He Q, Tang S, Wang C, Liu S, Wang UJ, Liu Y, Liu C, Liu H, Shiv Kumar Sarin, Qi Xiaolong. Development and validation of a machine learning-based model for varices screening in compensated cirrhosis (CHESS2001): An international multicenter study. Gastrointest Endosc 2022; doi: https://doi.org/10.1016/j.gie.2022.10.018 (IF: 10.396)
  16. Chuan Liu*, Li jia*, YJ Wong*, Qing Xie*, Masahi Hirooka*, Hirayuki Enomoto*, Tae Hyung Kim, Amr Shaaban Hanafy, Ruiling HE, Yohei Koizumi, Yoichi Hiasa, Takashi Nishimura, Hiroko Iijima, Young Kul Jung, Hyung Joon Yim, Jianzhong Ma, Qing-Lei Zeng, Shiv Kumar Sarin, Qi Xiaolong. ABC: a novel algorihm to stratify decompensation risk in patients with compensated advanced chronic liver disease (CHESS2108): an international, multicenter cohort study. Accepted in Hepatology International (IF 6.047) *co-first author
  17. YJ Wong, Chew SY, Hsiang JC, Thurairajah PH, Kumar R, Teo EK, Gokhale RS, Noor IBM, Tan J. (2018). VIEKIRA PAK associated drug-induced interstitial lung disease: Case series with systematic review of literature. Clin Mol Hepatol 2018. doi: 10.3350/cmh.2018.0017 (Impact Factor: 6.01)
  18. M Putera, CK Tan, YJ Wong, R Kumar. Higher mortality in acute variceal hemorrhage: Is fresh frozen plasma alone to be blame? Liv Int 2021 [early view] (IF: 5.8)
  19. YJ Wong, MH Nguyen. Is it safe to treat chronic hepatitis C patients with decompensated cirrhosis with protease inhibitor-based direct-acting antiviral? Liver International 2022, PMID: 35220647 (IF 5.8)
  20. YJ Wong, Irani FG, Tan M, Teo M (2018). Massive upper gastrointestinal bleeding post-Whipple from anastomotic varices due to mesenteric hypertension. Endoscopy 50(7):E159-E162. doi: 10.1055/a-0595-7507 [Impact Factor: 5.196]
  21. YJ Wong, DWL Ho, JG Abraldes. Pre-emptive TIPSS in acute variceal bleeding: current status, controversies and the direction forward. Accepted in Journal of Clinical and Translational Hepatology 2022 [IF 5.065]
  22. YJ Wong, Teh JGX, Khor C, Tan DMY. Endoscopic ultrasound-guided choledochoduodenostomy and duodenal stenting for combined malignant biliary and duodenal obstruction. Endoscopy (early view) 2019. IF 5.196
  23. YJ Wong, PH Thurairajah, R Kumar, J Tan, Fock KM, Law NM, Li JW, A Kwek, Tan YB, Koh Y, Lee ZC, LS Kumar, Teo EK, Ang TL. Efficacy and safety of sofosbuvir/velpatasvir in a real world chronic hepatitis C genotype 3 cohort. Accepted in Journal of Gastroenterology & Hepatology (IF 4.0)
  24. YJ Wong, Jia Li, Chuan Liu, Zhaojin Chen, Yiong Huak Chan, Martin Putera, Kok Ban Teh, Tiing Leong Ang, Lili Zhao, Zhongyang Yan, Rahul Kumar, Xin LI, Xiaolong Qi. CHES-ALARM score to stratify decompensation risk in compensated advanced chronic liver disease patients: an international multicenter study. Journal of Gastroenterology & Hepatology 2022, PMID: 35253271 (IF 4.0)
  25. YJ Wong, Jia Li, Zhaojin Chen, Liu Chuan, Xiaolong Qi. Reply: CHESS-ALARM score: Can it raised the alarm accurately? Accepted in Journal of Gastroenterology & Hepatology 2022 [early view] (IF 4.1)
  26. YJ Wong, Zhaojin Chen, Jia Li, Chuan Liu, Xiaolong Qi, Chan Yong Huak. Reply: CHESS-ALARM score: is it a 5-year prediction score? Accepted in Journal of Gastroenterology & Hepatology 2022 [early view] (IF 4.1)
  27. Hussain I, YJ Wong, L Rahul. L Su, R Kumar. Does pre-emptive TIPSS improve survival after acute variceal bleeding? Systematic review, meta-analysis and trial-sequence analysis of randomized trial. Accepted in Journal of Gastroenterology & Hepatology 2021 (IF 4)
  28. JH Koh, ZH Liew, Gin Kee NG, Hui Ting Liu, Yew Chong Tam, AD Gottardi, YJ Wong. Efficacy and safety of direct oral anticoagulant versus vitamin K antagonist for portal vein thrombosis in cirrhosis: a systematic review and meta-analysis. Accepted in Digestive and Liver Disease 2021 (IF 4.09)
  29. Li Weiquan, T Chia, DW Chong, YJ Wong, Tiing Leong Ang. Artificial intelligence and polyp detection in colonoscopy: use of a single neural network to achieve rapid polyp localization for clinical use. Accepted for publication in Journal of Gastroenterology & Hepatology 2021 (IF 4)
  30. YJ Wong, JH Loh, DMY Tan (2019). Gastrointestinal: An uncommon case of severe esophagitis. J Gastroenterol Hepatol; 34(1): 7 (Impact Factor: 4.0)
  31. YJ Wong, Qiu TY, Tam TY, M Babu, D Adler. Efficacy and safety for IV albumin for non-spontaneous bacterial peritonitis infection among patients with cirrhosis: A systematic review and meta-analysis. Digestive and Liver Disease. IF: 4.01
  32. Ang TL, YJ Wong. Endohepatology: more progress but not yet ready for prime time. Accepted in Journal of Gastroenterology & Hepatology 2022 [early view] (IF 4.1) Doi: 10.1111/jgh.15914
  33. Loo JH, Xu FWX, Low TJ, Tay WX, Ang LS, Tam YC, PH Thurairajah, R Kumar, YJ Wong. Efficacy and safety of sofosbuvir/velpatasvir with or without ribavirin in hepatitis C genotype 3 compensated cirrhosis: a meta-analysis. World J Hepatol 2022; 14 (6): 1248-1257; Doi: https://dx.doi.org/10.4254/wjh.v14.i6.1248 [IF 3.17]
  34. Chang PE, Tan CK, Cheah CC, Li W, Chow WC, YJ Wong. Validation of the expanded Baveno-VI criteria for screening gastroscopy in Asian with compensated advance chronic liver disease. Accepted for publication in Digestive Disease and Sciences. IF: 2.94
  35. Huang YW, Seah JJ, Tan CK, C Kam, J Tan, Teo EK, A Kwek, YJ Wong, M Tan, Ang TL, R Kumar. Modified AST to platelet ratio index improves APRI and better predicts advanced fibrosis and liver cirrhosis in patients with Non-alcoholic Fatty liver disease. Accepted for publication in Clinics and Research in Hepatology and Gastroenterology. IF: 2.718
  36. YJ Wong, Kumar R, Chua YJJ, Ang TL. Long-term albumin infusion in decompensated cirrhosis: A review of current literature. World J Hepatol. 2021 Apr 27;13(4):421-432. doi: 10.4254/wjh.v13.i4.421. PMID: 33959225; (IF: 2.77)
  37. Lee ZY, Suah BH, Teo YH,.. YJ Wong..Sia SC et al. Comparison of the Efficacy and Safety of Direct Oral Anticoagulants and Vitamin K Antagonists in Patients with Atrial Fibrillation and Concomitant Liver Cirrhosis: A Systematic Review and Meta-Analysis. Am J Cardiovasc Drugs. 2021;10.1007/s40256-021-00482-w. (IF: 2.67)
  38. Jing Hong Loo, YJ Wong. Albumin therapy for hepatic encephalopathy: current evidence and controversies. Accepted in Metabolic Brain Disease 2022 (IF: 2.63)
  39. Teh KB, Loo JH, Tam YC, YJ Wong. Efficacy and safety of albumin infusion for overt hepatic encephalopathy: A systematic review and meta-analysis. Dig Liver Dis. 2021 May 16:S1590-8658(21)00215-2. PMID: 34011479. (OIF: 2.37)
  40. YJ Wong, M Tan, Q Zheng, Li WQ, R Kumar, Fock KM, Teo EK, Ang TL. A systematic review and metaanalysis of the COVID-19 associated liver injury. Accepted for publication in Annals of Hepatology. IF: 2.12
  41. Teh KJ, Tay SW, Chen KN, Koh J S, YJ Wong, Kwek BE, Li W, Fock KM, Teo EK, Ang TL, Tan TK. Impact of enchanced personal protective equipment on colonoscopy performance during the COVID-19 pandemic. Endoscopy International Open 2020.
  42. Ang TL, J Li, YJ Wong, J Tan, Fock KM, Tan TMM, Kwek BEA, Teo EK, Ang SW, Wang LM. A prospective randomized study of colonoscopy using blue laser imaging and white light imaging in detection of colonic polyps. Endoscopy Open 2019;-7:E1207-1213.
  43. YJ Wong, Lum HM, Fook SC, Lim ST, Salazar E. Gastrointestinal tract lymphoma receiving chemotherapy: Does prophylactic total parenteral nutrition and bowel rest reduce the risk of perforation? Nutrition 2020 (IF: 3.42) DOI: https://doi.org/10.1016/j.nut.201903.023
  44. Tan YY, SKG Tay, YJ Wong, JW Li, BE Kwek, TL Ang, LM Wang, TK Tan. Clinical features and predictors of dysplasia in proximal sessile serrated lesions. Clin Endosc 2021 [early view] (IF: 1.8)
  45. Chang PE, YJ Wong, Yang WL et al. Recommendations and guidance for management of patients with liver disease in Singapore during the COVID-19 pandemic. Accepted for publication in Singapore Medical Journal. IF: 1.14
  46. YJ Wong, Lum HM, Tan PT, Teo EK, Jessica Tan, PH Thurairajah. Clinical implications of prompt ascitic drain removal among cirrhosis with refractory ascites. Accepted for publication in Singapore Medical Journal. IF: 1.14
  47. YJ Wong, R Kumar, Jessica Tan, PT Thurairajah. Author's reply: Comment on: Clinical implications of prompt ascitic drain removal in cirrhosis with refractory ascites. Singapore Medical Journal 2021; 62 (12): 666 (IF: 1.08)
  48. YJ Wong, K Rajamanickam, K Lin, J Tan, EK Teo, J Li, Ang TL (2019). Short-term and long-term predictors for spontaneous bacterial peritonitis in Singapore. Accepted for publication in Singapore Medical Journal (Impact Factor: 1.08)
  49. TL Ang, KW Lim, Daphne Ang, YJ Wong, M Tan, SYA Wong. Current audit of current Helicobacter pylori treatment outcomes in Singapore. Accepted in Singapore Med J 2021 (IF: 1.14)
  50. R Rana, S Sharma, S Ahmed, A Gupta, YJ Wong, D Gunjan, S Anoop. Evaluating the practice of prescribing beta-blocker in compensated cirrhosis by gastroenterologists in the Asia Pacific region. Clinical and Experimental Hepatology 2022 Sept 20. Doi: heeps://doi.org/10.1016/j.ceh.2022.09.003
  51. YJ Wong, Cheen M, Hsiang JC, Kumar R, Tan J, Teo EK, Thurairajah PH (2018). Economic evaluation of direct-acting antiviral for the treatment of Genotype 3 Hepatitis C infection in Singapore. JGH Open. doi:10.1002/jgh3.12139
  52. SM Alhamid, DX Lee, HM Wong, MB Chuah, YJ Wong, K Narasimhalu, TT Tan, SY Low (2016). Implementing electronic handover: interventions to improve efficiency, safety and sustainability. Int J Qual Health Care; 28(5): 608-614 (Impact Factor: 2.554)
  53. YJ Wong, Choo KJL, Soh JXJ, Tan CK (2018). Cytomegalovirus (CMV) hepatitis: an uncommon complication of CMV reactivation in drug reaction with eosinophilic and systemic symptoms. Singapore Med J; 59(1): 112-113. doi: 10.11622/smedj.2018016 (Impact Factor: 1.08)
  54. YJ Wong, Choo KJL, Soh JXJ, Tan CK (2018). Author's reply: Comment on: Cytomegalovirus (CMV) hepatitis: an uncommon complication of CMV reactivation in drug reaction with eosinophilic and systemic symptoms. Singapore Med J; 59(5): 289-290 (Impact Factor: 1.08)
  55. Qiu TY, See JJ, Shi HY, YJ Wong. Acute liver failure and seizure: a case report of an unusual presentation of acute painless aortic dissection. Accepted for publication in European Heart Journal – Case report 2020.
  56. YJ Wong, Tan BH, Leow WQ, SJ Mesenas (2018). Cytomegalovirus masquerading as gastric cancer in an immunocompromised host. Proceedings of Singapore Healthcare 27(1): 63-66. doi:10.1177/2010105817731797
  57. YJ Wong, Eng HK, Lath N, Namasivayam V (2018). Clinical features of paraduodenal hernia. Proceedings of Singapore Healthcare 27(2): 139-142.
  58. YJ Wong, Tan BX, Chlebicki MP, Schwender BJ (2017). Abiotrophia defectiva: A rare gut pathogen resulting endocarditis in inflammatory bowel disease. Journal of Microbiology and Infectious Disease 7(4): 217-219. doi:10.5799/jmid.369281

Research Trials

  • Early detection of Hepatocellular carcinoma in a High-risk Prospective Cohort (ELEGANCE); Site-PI, 2021 - Present
  • Efficacy and safety investigation of NNC0194-0499 co-administered with semaglutide in subjects with non-alcoholic steatohepatitis: a dose-ranging, placebo-controlled trial; Site-PI, 2021 - Present