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Cardiovascular Homograft Transplant

Overview of Homograft Transplant

When does a patient require a homograft  (heart valve) transplant?

Homograft or heart valve implant surgery is done to replace heart valves that are not functioning properly. Patients who require heart valve implantation surgery include those who are born with heart valve defects (e.g.Hole in the Heart) or those with diseased or infected heart valves.

Symptoms of heart valve malfunction

Heart valve diseases disturb the normal flow of blood through the heart. Patients may experience symptoms such as breathlessness, palpitations, tiredness and dizzy spells. This may affect their overall health and prevent them from enjoying daily and outdoor activities.

Eligibility of implantation

Patients who are born with heart valve defects or have infected heart valves will be assessed via echocardiography by the cardiologist. The cardiologist will then discuss with the surgical team and the patient regarding the choice of valves for a heart valve surgery.

Programme Highlights

The National Cardiovascular Homograft Bank (NCHB) was founded in February 2008 as the first and only heart valve bank in Singapore in order to respond to the growing demand of heart surgeons for human heart valves and vascular tissues to patients nationwide.

  • In 2012, NCHB achieved accreditation from American Association of Tissue Bank (AATB) and recognises NCHB as the first tissue bank outside North America. The accreditation signifies NCHB commitment in promoting the safety, quality and availability of donated human heart valve tissue for heart patients.

  • Over 80 heart valve implants have been performed, out of which 45% are paediatric patients aged 18 years old and below.

Our Specialists

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Dr Chakaramakkil Mathew Jose is the Programme Director of the Cardiovascular Homograft Transplant Programme.


The Cardiovascular Homograft team consists of a group of physicians, surgeons, nurses, transplant coordinators and scientific officers from the National Heart Centre Singapore The team undergoes regular training at leading tissue banks and participates in international conferences in Australia, Europe and the United States to equip themselves with the latest and highest standard of tissue banking.

In 2011, all our Tissue Bank Directors, senior scientific officer and transplant coordinator were certified to be Tissue Bank Specialists, a professional mark awarded by the American Association of Tissue Bank (AATB) to those who have met the requirements in education, experience and competency with its tissue banking standards.

Contact Information

Please contact:
National Cardiovascular Homograft Bank
National Heart Centre Singapore
Tel: +65  6704 8150
Fax: +65  6844 9035
Email: homograftdonation@nhcs.com.sg
Website: www.singhealth.com.sg/transplant