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Drug Class: Commonly Known As: Category:
Mekinist Cancer-related

Trametinib - Side Effects, Precautions, and Contraindications

What side effects can Trametinib cause?

Common side effects include:

  • Skin rash (acne-like) ​
    • Moisturize your skin daily.
    • Avoid too much exposure to the sun as it may make the rash worse. Use sunscreen and covered clothing if you need to be under the sun for a long period of time.
  • Diarrhea
    • Drink plenty of fluids to replace those lost (2 litres everyday).
    • Avoid oily or spicy food and milk or dairy products.
  • Nausea (especially when treated together with Dabrafenib)
    • Take small, frequent meals throughout the day.
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired.
  • Joint or muscle ache
    • Apply a warm compress to the area that aches.
  • Increased blood pressure
    • Monitor your blood pressure regularly and record it down. Inform your doctor if you notice an increasing trend.

Rare but serious side effects include:

  • Unusual swelling of the ankles or feet
  • Sudden onset of cough, chest pain or shortness of breath
  • Fever of 38°C and above, especially with chills, pain or difficulty in passing urine
  • Unusual bleeding, bruising or black sticky stools
  • Warmth, pain, redness or discoloration on the arm or leg
  • Change in eyesight or eye pain
  • Very bad headache or giddiness

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Trametinib , what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication
  • You or your partner become pregnant or is planning for pregnancy
    • You should use effective birth control during and for 4 months after stopping Trametinib.
  • You are breastfeeding
    • Do not breastfeed during and for 4 months after stopping Trametinib.
  • You have any other medical conditions such as heart problems or diabetes
  • You plan to have surgery, dental procedure or any other medical procedures done 

What food or medicine must I avoid when I take Trametinib ?

​Inform your healthcare professional if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies.

Trametinib - Additional Information

​You may refer to the following website if you need more information:

  • Updated on 9/30/2019 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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