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Regorafenib

Drug Class: Commonly Known As: Category:
Multi-Kinase Inhibitor Stivarga® Cancer-related

Regorafenib - What is it for

​Regorafenib is a targeted medication used to treat certain advanced cancers e.g. colorectal, liver and gastrointestinal stromal tumor (GIST).

Regorafenib - Side Effects, Precautions, and Contraindications

What side effects can Regorafenib cause?

  • Palms of the hands or soles of the feet become numb, sore, red or dry
  • Diarrhea, stomach discomfort
  • Nausea, decreased appetite
  • Mouth sores or ulcers
  • High blood pressure
  • Tiredness or lack of energy
  • Increased risk of infection
    Maintain hygiene, avoid crowds and people with infection. 
  • Voice change or hoarseness

Inform your doctor if any of the following occurs:

  • Painful blistering or swelling of hands or feet
  • Signs of unusual bleeding e.g. unexplained bruises or black, sticky stools
  • Chest pain or tightness, shortness of breath
  • Yellowing of the skin or eye, or dark tea-coloured urine
  • Severe abdominal pain, nausea, vomiting
  • Fever of 38 ˚C or higher
  • Severe headache, giddiness, confusion or change in vision

Before taking Regorafenib, what precautions must I follow?

  • Use effective birth control during treatment and for at least 2 months after stopping Regorafenib. Inform your doctor if you or your partner plan for or suspect pregnancy.
  • Inform your doctor or pharmacist if you:
    • Have any surgery planned.
    • Have any other medical conditions e.g. high blood pressure, heart problems.
    • Are taking any other medication or supplements.

What food or medicine must I avoid when I take Regorafenib?

Avoid grapefruit and its juice while you are on this medication.

Regorafenib - Dosage and How to Use

How should Regorafenib be used?

It is a tablet, taken by mouth and swallowed whole with water after a light (low-fat) meal. Take once daily at around the same time each day for 3 weeks out of a 4-week cycle.

Take the exact number of tablets instructed by your doctor.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you can on the same day and then go back to your usual dosing time the next day. Do not double dose.

What should I do if I overdose?

If you overdose on this medication, inform your doctor immediately.

Regorafenib - Handling and Storage

How should I handle Regorafenib safely?

Do not break or crush the tablets.

How should I store Regorafenib?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Regorafenib safely?

Regorafenib - Additional Information

  • Updated on Monday, March 4, 2019
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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