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Topical Estrogen (Oestrogel and Divigel)

Drug Class: Commonly Known As: Category:
Oestrogel, Divigel

Topical Estrogen (Oestrogel and Divigel) - Side Effects, Precautions, and Contraindications

What side effects can Topical Estrogen (Oestrogel and Divigel) cause?

Common side effects include:

  • Breast tenderness
  • Headache
    • You may take Paracetamol to manage headaches. Do make sure that you are drinking enough water.
  • Nausea, vomiting, bloating and stomach cramps
    • You may consume smaller but more frequent meals, and avoid spicy, fatty food.
  • Skin irritation at site of application
    • Alternate application sites e.g. you can apply the gel over both your outer arms one day, and on another day, to both your thighs instead.
Consult your doctor about any symptom that becomes bothersome.

Taking HRT increases a woman’s risk of developing blood clots and breast cancer. However, these are rare and the doctor would have evaluated and weighed its benefits over risks before making the recommendation. Please discuss with your doctor if you have any concerns.

The symptoms of blood clot include one or more of the following: 
  • Any unusual sudden cough, breathlessness or difficulty in breathing
  • Severe pain in the chest which may reach the left arm
  • Severe pain in the legs or swelling in either of your legs
  • Weakness or numbness in any part of your body
  • Change in your speech, including slurring of words
  • Change in your senses of hearing, smell or taste
  • Vision changes such as loss of vision/ blurred vision
It is also advisable to regularly check your breasts while you are on HRT.  If you notice any unusual changes, please see your doctor immediately. 

Other rare but serious side effects that you may or may not experience:
  • Have unexpected, heavy or longer than usual menstrual bleeding
  • Experience dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin. These may be signs of liver disease.
  • Experience bothersome mood changes

The symptoms of a drug allergy include one or more of the following: 
  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body
If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Topical Estrogen (Oestrogel and Divigel) , what precautions must I follow?

Inform your healthcare professional if:
  • You are allergic to this medication or any of the other ingredients of this medication.
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.
  • You have unexplained vaginal bleeding.
  • You have a history of or current medical conditions such as liver problems, stroke, heart disease, blood clots, migraine headaches, epilepsy (fits), diabetes mellitus, cancer or have unexplained vaginal bleeding.
  • You are going for surgery or will be on bed rest.

What food or medicine must I avoid when I take Topical Estrogen (Oestrogel and Divigel) ?

  • Updated on 5/31/2022 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth


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