What is Insulin?
Insulin is a hormone produced by the pancreas that allows the body to use blood sugar for energy. Carbohydrates, a type of nutrient found in starchy foods such as bread, noodles, potatoes and rice, are converted into sugar and absorbed into the bloodstream. Insulin allows sugar from the bloodstream to enter the body cells and be used to create energy or be stored for future use.
People with diabetes are unable to fully use the sugar in their bloodstream either because their bodies do not make enough insulin or the cells do not respond well to insulin, a situation known as insulin resistance. Hence, they would need more insulin to get the same effects.
Insulin Therapy
There are two main groups of patients with diabetes and their treatment could be different.
Insulin is injected into the fatty tissue that is between the skin and muscle layer.
Starting on insulin when already on oral tablets for T2DM patients
T2DM is a progressive illness. This means that what you did at the beginning to control your condition through your diet, exercise or medications may change over time.
As your diabetes progresses, the management of your condition can change from diet and exercise alone, to adding oral diabetes medications. Patients who have had diabetes for a long time may naturally find that they progress to a combination of oral diabetes medications and insulin.
Some T2DM patients might feel that once they have started insulin, it could mean that their condition is now very serious or they have "failed" in controlling their diabetes. However, it is important to understand that this is a natural progression of the disease. If your diabetes is not controlled, it can lead to serious health complications such as an increased risk of heart disease and eye or kidney problems.
If you are on insulin, you should know how to:
Types of Insulin
There are several types of insulin. They differ mainly in how quickly they start to lower blood sugar once injected, and how long their effects last in the body.
Type
When to take it
When the medication starts working after you have injected it
How long does the medication effect last after you have injected it
Rapid-acting - Apidra®
- Novorapid®
- Humalog®
Immediately before a meal
10-20 minutes
2-4 hours
Short-acting - Actrapid® HM
- Humulin® R
30 minutes before a meal
30 minutes
6-8 hours
Intermediate-acting - Humulin® N - Insulatard® HM
Before breakfast and/or at bedtime
1-3 hours
16-24 hours
Long-acting
- Levemir® - Lantus®
- Toujeo®
- Tresiba®
- Soliqua® *
Daily at the same time (eg. bedtime)
3-4 hours
Variable.
Up to 24 hours for Levemir®, Lantus® and Soliqua®.
May last more than 24h for Toujeo® and Tresiba®.
Pre-mixed
These are mixtures of rapid/ short-acting and intermediate/ long-acting insulins
- Humalog® Mix
- Novomix® 30
- Mixtard® 30
- Humulin® 30/70
- Ryzodeg®
Variable, inject before meals. Refer to your medication label for timing of injection for your specific type of pre-mixed insulin
Variable
Variable, 14 to more than 24 hours
Low blood sugar (hypoglycemia) is more likely to occur around the time of maximum action. High blood sugar (hyperglycemia) is more likely to occur before the insulin starts acting or when its action is ending.
*Soliqua® is a combination of long-acting insulin and lixisenatide (another type of diabetes medication class known as GLP1 agonist)
The most common side effect with the use of insulin is low blood sugar. If you inject insulin but do not eat on time, your blood sugar may become too low. Low blood sugar levels might also happen if you do not eat well or if you drink alcohol on an empty stomach while on insulin therapy.
Symptoms of low blood sugar include:
If you experience any of these low blood sugar symptoms, do the following immediately:
Step 1: Check your blood sugar level with a home blood sugar meter (glucometer) if available. If your blood sugar level is less than 4 mmol/L, take 15 grams of fast-acting sugar such as:
Step 2: Monitor yourself for 15 minutes. If you have a glucometer (home blood sugar meter), check your blood sugar level again after 15 minutes.
Step 3: If your blood sugar level is still less than 4 mmol/L or you still have symptoms of low blood sugar, you should take another 15 grams of fast-acting sugar as per Step 1.
If your symptoms do not go away, see a doctor or go to the hospital immediately. Step 4: Take your meal or snack if your blood sugar level is 4 mmol/L and above after consuming the fast-acting sugar earlier on. Inform your doctor about this during the next visit.
If your symptoms do not go away, see a doctor or go to the hospital immediately.
Step 4: Take your meal or snack if your blood sugar level is 4 mmol/L and above after consuming the fast-acting sugar earlier on.
Inform your doctor about this during the next visit.
Other side effects include:
How to Injection Insulin
Knowing where to inject your insulin will make the injection easier, safer and more comfortable. Insulin is injected into the fatty tissue that is between the skin and muscle layer. After insulin is injected, it is absorbed into the blood and is used by your body.
There are three main areas of injection:
Your doctor or nurse will advise you on the best area to inject. You should keep to the same injection area (abdomen OR arm OR thigh/buttock) to ensure consistent insulin absorption.
You should rotate the injection site within the same area to prevent your body from forming lipodystrophy (a small lump or dent in the skin that forms when a person repeatedly injects in the same spot).
If you are injecting into the abdomen area, inject at least two inches away from the belly button and avoid areas with scars or bruises.
Insulin Devices
Syringes are used to deliver the correct and accurate insulin doses to patients. Choose a suitable syringe that best matches the number of units required.
A 0.3mL syringe should be used for doses up to 30 units. A 0.5mL syringe should be used for doses up to 50 units. A 1mL syringe can be used for doses up to 100 units.
Do not reuse insulin syringes. Throw away the syringe after every injection.
Insulin Pens
Insulin pens combine both the insulin cartridge and measuring dial into one device. Some insulin pens are disposable whereas some are reusable. Thus, insulin injections become more convenient as you do not have to carry syringes and insulin vials separately with you.
Insulin Pumps
The insulin pump is a small computerised device that pumps insulin continuously through a fine plastic tube into a site under the skin throughout the day.
Pump users have to monitor their blood sugar frequently so as to make adjustments to the amount of insulin delivered. The insulin pump generally gives you better control and more meal flexibility but is more expensive and requires more frequent blood sugar monitoring.
Handling and Storage
Unopened insulin should be stored in the refrigerator (not in the freezer). Frozen insulin cannot be used. You should always keep at least one extra vial or pen of each type of insulin.
Once opened, the insulin vial or pen should be stored at room temperature and away from direct sunlight. The opened insulin vial or pen can be kept for four to six weeks depending on the type of insulin you use. Refer to your medication label to check how long you can keep your insulin for.
When you are travelling, carry your insulin and syringes with you. Do not put the insulin in your check-in luggage or in your car boot.
Discard the insulin if
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