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Anti-Tumour Necrosis Factor (Anti-TNF)

Drug Class: Commonly Known As: Category:
Tumor Necrosis Factor Inhibitor Adult

Anti-Tumour Necrosis Factor (Anti-TNF) - Dosage and How to Use

How should Anti-Tumour Necrosis Factor (Anti-TNF) be used?

It may be given by injection under the skin, e.g.: Adalimumab, Etanercept, Certolizumab and Golimumab (administer at home) or by infusion, e.g.: Infliximab (administer in hospital up to 2-4 hours)

Injection under the skin can be injected into the abdomen or thigh.

Starting, maintenance dose and time to effect :

DrugUsual Dosing RegimenTime to Effect
Infliximab

Initial: 3-5 mg/kg (Week 0, 2, 6)

Maintain: 5-10mg/kg every 4-8 w

2-3 weeks
Adalimumab40mg every other week 2-3 weeks
Etanercept50mg once a week1-2 weeks
Certolizumab

Initial: 400mg (Week 0, 2, 4)

Maintain: 200mg every other week

1-2 weeks
Golimumab50mg once a month1-2 weeks

What should I do if I miss a dose?

Take the missed dose as soon as you remember.

Then take your next injection as you would have on your originally scheduled day.

If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

Do not take a double dose to make up a missed dose.

What should I do if I overdose?

  • Updated on Friday, June 12, 2015
  • Article contributed by Pharmacy Singapore General Hospital

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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